Skip to main content
SpringerLink
Log in
Book cover

Arzneiverordnungs-Report 2008 pp 661–690Cite as

Magen-Darm-Mittel und Laxantien

  • Chapter

  • 548 Accesses

Zusammenfassung

Bedeutsamste Gruppe der Magen-Darm-Mittel sind mit großem Abstand vor allen anderen Präparategruppen und mit unverändert steigender Tendenz nach wie vor die Protonenpumpenhemmer. Zweitgrößte Gruppe, aber in deutlichem Abstand der Verordnungen und mit weiter fallender Tendenz, sind die H2-Rezeptorenblocker. Gering zugenommen hat die Verordnung von motilitätssteigernden Mitteln und von Medikamenten gegen chronisch-entzündliche Darmkrankheiten. Kleinere Verordnungsvolumina entfallen auf Laxantien, Antidiarrhoika, Pankreasenzyme und Spasmolytika.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Arzneimittelkommission der deutschen Ärzteschaft (2006): Arzneiverordnungen. Empfehlungen zur rationalen Pharmakotherapie. 21. Auflage, Deutscher Ärzte-Verlag Köln, S. 907–921.

    Google Scholar 

  • Beker JA, Bianchi Porro G, Bigard MA, Delle Fave G, Devis G, Gouerou H, Maier C (1995): Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer. Eur J Gastroenterol Hepatol 7: 407–410.

    CAS  PubMed  Google Scholar 

  • Bombardier C, Laine L, Reicin A et al (2000): Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med 343: 1520–1528.

    Article  CAS  PubMed  Google Scholar 

  • Borowitz D, Goss CH, Stevens C, Hayes D, Newman L, O’Rourke A, Konstan MW, Wagener J, Moss R, Hendeles L, Orenstein D, Ahrens R, Oermann CM, Aitken ML, Mahl TC, Young KR, Dunitz J, Murray FT (2006): Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patients. Pancreas 32: 258–263.

    Article  CAS  PubMed  Google Scholar 

  • Bour B, Staub JL, Chousterman M, Labayle D, Nalet B, Nouel O, Pariente A, Tocque E, Bonnot-Marlier S (2005): Long-term treatment of gastro-oesophageal reflux disease patients with frequent symptomatic relapses using rabeprazole: on-demand treatment compared with continuous treatment. Aliment Pharmacol Ther 21: 805–812.

    Article  CAS  PubMed  Google Scholar 

  • Bouras EP, Scolapio JS (2004): Gastric motility disorders: management that optimizes nutritional status. J Clin Gastroenterol 38: 549–557.

    Article  PubMed  Google Scholar 

  • Caspary WF, Lüpke NP, Oldiges FJ, Wahle K (1995): Diarrhoe in der ärztlichen Praxis. Münch Med Wochenschr 137: 411–415.

    Google Scholar 

  • Catalano F, Branciforte G, Catanzaro R, Bentivegna C, Cipolla R, Nuciforo G, Brogna A (1999): Comparative treatment of Helicobacter pylori-positive duodenal ulcer using pantoprazole at low and high doses versus omeprazole in triple therapy. Helicobacter 4: 178–184.

    Article  CAS  PubMed  Google Scholar 

  • Chan FK, Hung LC, Suen BY, Wu JC, Lee KC, Leung VK, Hui AJ, To KF, Leung WK, Wong VW, Chung SC, Sung JJ (2002): Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med 347: 2104–2110.

    Article  CAS  PubMed  Google Scholar 

  • Chan FK, Ching JY, Hung LC, Wong VW, Leung VK, Kung NN, Hui AJ, Wu JC, Leung WK, Lee VW, Lee KK, Lee YT, Lau JY, To KF, Chan HL, Chung SC, Sung JJ (2005): Clopidogrel versus aspirin and esomeprazole to prevent recurrent ulcer bleeding. N Engl J Med 352: 238–244.

    Article  CAS  PubMed  Google Scholar 

  • Corinaldesi R, Valentini M, Belaiche J, Colin R, Geldof H, Maier C (1995): Pantoprazole and omeprazole in the treatment of reflux oesophagitis: a European multicentre study. Aliment Pharmacol Ther 9: 667–671.

    Article  CAS  PubMed  Google Scholar 

  • Dalrymple J, Bullock I (2008): Diagnosis and management of irritable bowel syndrome in adults in primary care: summary of NICE guidance. BMJ 36: 556–558.

    Article  Google Scholar 

  • DeVault KR, Castell DO; American College of Gastroenterology (2005): Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 100: 190–200.

    Article  PubMed  Google Scholar 

  • De Vrese M, Marteau PR (2007): Probiotics and prebiotics: effects on diarrhea. J Nutr 137(3 Suppl 2):803S–811S.

    PubMed  Google Scholar 

  • Ellenrieder V, Boeck W, Richter C, Marre R, Adler G, Glasbrenner B (1999): Prevalence of resistance to clarithromycin and its clinical impact on the efficacy of Helicobacter pylori eradication. Scand J Gastroenterol 34: 750–756.

    Article  CAS  PubMed  Google Scholar 

  • Hawkey CJ, Karrasch JA, Szczepanski L, Walter DG, Barkun A et al (1998): Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med 338: 727–734.

    Article  CAS  PubMed  Google Scholar 

  • Hellers G, Cortot A, Jewell D et al (1999): Oral budesonide for prevention of postsurgical recurrence in Crohn’s disease. Gastroenterology 116: 294–300.

    Article  CAS  PubMed  Google Scholar 

  • Kark W, Krebs-Richter H, Hotz J (1995): Improving the effect of orthograde colonic lavage with golytely solution by adding dimethicone. Z Gastroenterol 33: 20–23.

    CAS  PubMed  Google Scholar 

  • Koop H, Schepp W, Muller-Lissner S, Madisch A, Micklefield G, Messmann H, Fuchs KH, Hotz J (2005): Gastroösophageale Refluxkrankheit — Ergebnisse einer evidenzbasierten Konsensuskonferenz der Deutschen Gesellschaft für Verdauungs-und Stoffwechselkrankheiten. Z Gastroenterol 43: 165–194.

    Article  Google Scholar 

  • Körner T, Schutze K, van Leendert RJ, Fumagalli I, Costa Neves B, Bohuschke M, Gatz G (2003): Comparable efficacy of pantoprazole and omeprazole in patients with moderate to severe reflux esophagitis. Results of a multinational study. Digestion 67: 6–13.

    Article  PubMed  Google Scholar 

  • Labenz J, Armstrong D, Lauritsen K, Katelaris P, Schmidt S, Schutze K, Wallner G, Juergens H, Preiksaitis H, Keeling N, Naucler E, Adler J, Eklund S (2005): Esomeprazole 20 mg vs. pantoprazole 20 mg for maintenance therapy of healed erosive oesophagitis: results from the EXPO study. Aliment Pharmacol Ther 22: 803–811.

    Article  CAS  PubMed  Google Scholar 

  • Labenz J, Tillenburg B, Peitz U, Köhl H, Becker T et al (1996): Ulcusheilung durch Helicobacter-pylori-Eradikation: Genügt eine Woche Therapie? Dtsch Med Wochenschr 121: 3–8.

    Article  CAS  PubMed  Google Scholar 

  • Lee JM, Breslin NP, Hyde DK, Buckley MJ, O’Morain CA (1999): Treatment options for Helicobacter pylori infection when proton pump inhibitor-based triple therapy fails in clinical practice. Aliment Pharmacol Ther 13: 489–496.

    Article  CAS  PubMed  Google Scholar 

  • Lesbros-Pantoflickova D, Michetti P, Fried M, Beglinger C, Blum AL (2004): Meta-analysis: The treatment of irritable bowel syndrome. Aliment Pharmacol Ther 20: 1253–1269.

    Article  CAS  PubMed  Google Scholar 

  • Lind T, Mégraud F, Unge P, Bayerdörffer E, O’Morain C, Spiller R, van Zenten S et al (1999): The MACH 2 study: Role of omeprazole in eradication of Helicobacter pylori with I-week triple therapies. Gastroenterology 116: 248–253.

    Article  CAS  PubMed  Google Scholar 

  • Lüth S, Teyssen S, Kölbel CB, Singer MV (2001): 4 day triple therapy with rabeprazole, amoxicillin and clarithromycin in the eradication of Helicobacter pylori in patients with peptic ulcer disease. Z Gastroenterol 39: 279–285.

    Article  PubMed  Google Scholar 

  • Malfertheiner P, Megraud F, O’Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ (2007): Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 56:772–781.

    Article  CAS  PubMed  Google Scholar 

  • Metcalf TJ, Irons TG, Sher LD, Young PC (1994): Simethicone in the treatment of infant colic: a randomized placebo-controlled multicenter trial. Pediatrics 94: 29–34.

    CAS  PubMed  Google Scholar 

  • Miehlke S, Schneider-Brachert W, Kirsch C, Morgner A, Madisch A, Kuhlisch E, Haferland C, Bästlein E, Jebens C, Zekorn C, Knoth H, Stolte M, Lehn N (2008): One-week once-daily triple therapy with esomeprazole, moxifloxacin, and rifabutin for eradication of persistent Helicobacter pylori resistant to both metronidazole and clarithromycin. Helicobacter. 13: 69–74.

    Article  CAS  PubMed  Google Scholar 

  • Mössner J, Hölscher AH, Herz R, Schneider A (1995): A double-blind study of pantoprazole and omeprazole in the treatment of reflux oesophagitis: a multicentre trial. Aliment Pharmacol Ther 9: 321–326.

    Article  PubMed  Google Scholar 

  • Mulder CJ, Westerveid BD, Smit JM, Oudkerk Pool M, Otten MH, Tan TG, van Milligen de Wit AW, de Groot GH; Dutch omeprazole MUPS study group (2002): A double-blind, randomized comparison of omeprazole Multiple Unit Pellet System (MUPS) 20 mg, lansoprazole 30 mg and pantoprazole 40 mg in symptomatic reflux oesophagitis followed by 3 months of omeprazole MUPS maintenance treatment: a Dutch multicentre trial. Eur J Gastroenterol Hepatol 14: 649–656.

    Article  CAS  PubMed  Google Scholar 

  • National Institute for Clinical Excellence (2004): Dyspepsia: management of dyspepsia in adults in primary care. Clinical Guideline 17. Internet: www.nice.org.uk/page.aspx?o=CG017NICEguideline

    Google Scholar 

  • Peura DA, Gudmundson J, Siepman N, Pilmer BL, Freston J (2007): Proton pump inhibitors: effective first-line treatment for management of dyspepsia. Dig Dis Sci 52: 983–987.

    Article  CAS  PubMed  Google Scholar 

  • Poynard T, Regimbeau C, Benhamou Y (2001): Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome. Aliment Pharmacol Ther 15:355–361.

    Article  CAS  PubMed  Google Scholar 

  • Prasad S, Dhiman RK, Duseja A, Chawla YK, Sharma A, Agarwal R (2007): Lactulose improves cognitive functions and health-related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology 45: 549–559.

    Article  PubMed  Google Scholar 

  • Rehner M, Rohner HG, Schepp W (1995): Comparison of pantoprazole versus omeprazole in the treatment of acute duodenal ulceration—a multicentre study. Aliment Pharmacol Ther 9: 411–416.

    Article  CAS  PubMed  Google Scholar 

  • Richter JE, Bochenek W (2000): Oral pantoprazole for erosive esophagitis: a placebo-controlled, randomized clinical trial. Pantoprazole US GERD Study Group. Am J Gastroenterol 95: 3071–3080.

    Article  CAS  PubMed  Google Scholar 

  • Rutgeerts P, Löfberg R, Malchow H et al (1994): A comparison of budesonide with prednisolone for active Crohn’s disease. N Engl J Med 331: 842–845.

    Article  CAS  PubMed  Google Scholar 

  • Schmieder G, Stankov G, Zerle G, Schinzel S, Brune K (1993): Observer-blind study with metamizole versus tramadol and butylscopolamine in acute biliary colic pain. Arzneim Forsch 43: 1216–1221.

    CAS  Google Scholar 

  • Sjöstedt S, Befrits R, Sylvan A, Harthon C, Jörgensen L, Carling L, Modin S, Stubberöd A, Toth E, Lind T (2005): Daily treatment with esomeprazole is superior to that taken on-demand for maintenance of healed erosive oesophagitis. Aliment Pharmacol Ther 22: 183–191.

    Article  PubMed  Google Scholar 

  • Smith DS, Ferris CD (2003): Current concepts in diabetic gastroparesis. Drugs 63: 1339–1358.

    Article  PubMed  Google Scholar 

  • Stedman CA, Barclay ML (2000): Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors. Aliment Pharmacol Ther 14: 963–978.

    Article  CAS  PubMed  Google Scholar 

  • Sudduth RH, DeAngelis S, Sherman KE, McNally PR (1995): The effectiveness of simethicone in improving visibility during colonoscopy when given with a sodium phosphate solution: a double-bind randomized study. Gastrointest Endosc 42: 413–415.

    Article  CAS  PubMed  Google Scholar 

  • Talley NJ (2003): Evaluation of drug treatment in irritable bowel syndrome. Br Clin Pharmacol 56: 362–369.

    Article  CAS  Google Scholar 

  • van Zanten SV, Armstrong D, Chiba N, Flook N, White RJ, Chakraborty B, Gasco A (2006): Esomeprazole 40 mg once a day in patients with functional dyspepsia: the randomized, placebo-controlled „ENTER” trial. Am. J Gastroenterol 101: 2096–2106. Erratum in: Am J Gastroenterol. 2006; 101: 2171.

    Article  PubMed  Google Scholar 

  • Vcev A, Stimac D, Vceva A, Takac B, Ivandic A, Pezerovic D, Horvat D, Nedic P, Kotromanovic Z, Maksimovic Z, Vranjes Z, Males J, Jurisic-Orzen D, Vladika I, Stimac T, Mandic B (1999): Pantoprazole versus omeprazole in the treatment of reflux esophagitis. Acta Med Croatica 53: 79–82.

    CAS  PubMed  Google Scholar 

  • Witzel L, Gutz H, Huttemann W, Schepp W (1995): Pantoprazole versus omeprazole in the treatment of acute gastric ulcers. Aliment Pharmacol Ther 9: 19–24.

    Article  CAS  PubMed  Google Scholar 

  • Wolfe MM, Lichtenstein DR (1999): Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340: 1888–1899.

    Article  CAS  PubMed  Google Scholar 

  • Wolle K, Malfertheiner P (2007): Treatment of Helicobacter pylori. Best Pract Res Clin Gastroenterol 21: 315–324.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik II der Universität Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig

    Prof. Dr. med. Joachim Mössner

Authors
  1. Prof. Dr. med. Joachim Mössner
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg

    Ulrich Schwabe

  2. Die Gesundheitskasse, AOK Schleswig-Holstein, Edisonstraße 70, 24145, Kiel

    Dieter Paffrath

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Mössner, J. (2008). Magen-Darm-Mittel und Laxantien. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69219-5_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-69219-5_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69218-8

  • Online ISBN: 978-3-540-69219-5

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation