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Granule-Mediated Cytotoxicity

  • Chapter
Apoptosis: Biology and Mechanisms

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 23))

Abstract

Cytotoxic T lymphocytes (CTLs) represent the body’s primary line of defence against virus-infected and tumourigenic cells, and may play a role in autoimmune diseases and organ transplant rejection. CTLs are able to carry out their essential functions due to their ability to specifically recognize and destroy “foreign” cells. In this case, foreign may be defined as self cells which have mutated or become infected, or, alternatively, if specificity is somehow disrupted, they may be normal self cells. Whatever the case, CTLs may use one of two mechanisms to destroy the recognized target cell — one which is granule based, and one mediated by cell surface receptors on the target cell, for which the ligand is expressed on the CTL (see Chap. by Trapani and Jans in this Volume). This chapter focuses on mechanisms of target cell destruction during granule-mediated cytotoxicity.

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Authors and Affiliations

  1. Medical Research Council Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK

    Alison J. Darmon

  2. Department of Biochemistry, Medical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

    Michael J. Pinkoski & R. Chris Bleackley

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  1. Alison J. Darmon
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  1. Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Rundle Mall, P.O. Box 14, 5000, Adelaide, SA, Australia

    Sharad Kumar

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Darmon, A.J., Pinkoski, M.J., Bleackley, R.C. (1999). Granule-Mediated Cytotoxicity. In: Kumar, S. (eds) Apoptosis: Biology and Mechanisms. Results and Problems in Cell Differentiation, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69184-6_6

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