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Lipid and Glycolipid Mediators in CD95-Induced Apoptotic Signaling

  • Chapter
Apoptosis: Biology and Mechanisms

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 23))

Abstract

Ceramides play an important role mediating different cell responses such as proliferation, differentiation, growth arrest and apoptosis. They are released upon sphingomyelin hydrolysis which occurs after triggering of a number of cell-surface receptors including CD95. Ceramides generation also regulates glycosphingolipids and gangliosides metabolism. In particular, ganglioside GD3 biosynthesis may represent an important event for the progression of apoptotic signals generated by CD95 in hematopoietic cells.

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Authors and Affiliations

  1. Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, Via di Tor Vergata, 135, 00133, Rome, Italy

    Florence Malisan, Maria Rita Rippo, Ruggero De Maria & Roberto Testi

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  1. Florence Malisan
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  2. Maria Rita Rippo
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  3. Ruggero De Maria
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  4. Roberto Testi
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Editors and Affiliations

  1. Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Rundle Mall, P.O. Box 14, 5000, Adelaide, SA, Australia

    Sharad Kumar

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© 1999 Springer-Verlag Berlin Heidelberg

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Malisan, F., Rippo, M.R., De Maria, R., Testi, R. (1999). Lipid and Glycolipid Mediators in CD95-Induced Apoptotic Signaling. In: Kumar, S. (eds) Apoptosis: Biology and Mechanisms. Results and Problems in Cell Differentiation, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69184-6_4

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  • DOI: https://doi.org/10.1007/978-3-540-69184-6_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21623-1

  • Online ISBN: 978-3-540-69184-6

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