Abstract
In this chapter I will describe the sequence of events that culminated in the proposal of the apoptosis concept (Kerr et al. 1972). Since it is now many years since these events took place, it is possible that memory has become coloured by subsequent insights. The main steps in the story were, however, recorded in publications written at the time.
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References
Bessis M (1964) Studies on cell agony and death: an attempt at classification. In: de Reuck AVS, Knight J (eds), Ciba Foundation symposium on cellular injury. Churchill, London, pp 287–316
Biava C, Mukhlova-Montiel M (1965) Electron microscopic observations on Councilman-like acidophilic bodies and other forms of acidophilic changes in human liver cells. Am J Pathol 46: 775–802
Crawford AM, Kerr JFR, Currie AR (1972) The relationship of acute mesodermal cell death to the teratogenic effects of 7-OHM-12-MBA in the foetal rat. Br J Cancer 26: 498–503
de Reuck AVS, Cameron MP (eds), (1963) Ciba Foundation symposium on lysosomes. Churchill, London
Farbman AI (1968) Electron microscope study of palate fusion in mouse embryos. Dev Biol 18: 93–116
Garfield E, Melino G (1997) The growth of the cell death field: an analysis from the ISI-Science citation index. Cell Death Differ 4: 352–361
Georgatsos JG (1995) The s(p)elling of apo(p)tosis. Nature 375: 100
Glücksmann A (1951) Cell deaths in normal vertebrate ontogeny. Biol Rev 26: 59–86
Kerr JFR (1965) A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes. J Pathol Bacteriol 90: 419–435
Kerr JFR (1967) Lysosome changes in acute liver injury due to heliotrine. J Pathol Bacteriol 93: 167–174
Kerr JFR (1969) An electron-microscope study of liver cell necrosis due to heliotrine. J Pathol 97: 557–562
Kerr JFR (1970) An electron microscopic study of liver cell necrosis due to albitocin. Pathology 2: 251–259
Kerr JFR (1971) Shrinkage necrosis: a distinct mode of cellular death. J Pathol 105: 13–20
Kerr JFR (1972) Shrinkage necrosis of adrenal cortical cells. J Pathol 107: 217–219
Kerr JFR (1973) Some lysosome functions in liver cells reacting to sublethal injury. In: Dingle JT (ed), Lysosomes in biology and pathology 3. Frontiers of biology, vol 29. North-Holland, Amsterdam, pp 365–394
Kerr JFR, Searle J (1972a) A suggested explanation for the paradoxically slow growth rate of basal-cell carcinomas that contain numerous mitotic figures. J Pathol 107: 41–44
Kerr JFR, Searle J (1972b) The digestion of cellular fragments within phagolysosomes in carcinoma cells. J Pathol 108: 55–58
Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239–257
Kerr JFR, Gobé GC, Winterford CM, Harmon BV (1995) Anatomical methods in cell death. In: Schwartz LM, Osborne BA (eds), Cell death. Methods in cell biology, vol 46. Academic Press, San Diego, pp 1–27
Klion FM, Schaffner F (1966) The ultrastructure of acidophilic “Councilman-like” bodies in the liver. Am J Pathol 48: 755–767
Laird AK (1969) Dynamics of growth in tumors and in normal organisms. In: Perry S (ed), Human tumor cell kinetics. National Cancer Institute monograph, no 30. National Cancer Institute, Bethesda, pp 15–28
Lockshin RA (1997) The early modern period in cell death. Cell Death Differ 4: 347–351
Majno G, Joris I (1995) Apoptosis, oncosis and necrosis. An overview of cell death. Am J Pathol 146: 3–15
Moppert J, v Ekesparre D, Bianchi L (1967) Zur Morphogenese der eosinophilen Einzelzellnekrose im Leberparenchym des Menschen. Eine licht-and elektronenoptisch korrelierte Untersuchung. Virchows Arch Pathol Anat 342: 210–220
Rous P, Larimore LD (1920) Relation of the portal blood to liver maintenance: a demonstration of liver atrophy conditional on compensation. J Exp Med 31: 609–632
Saunders JW (1966) Death in embryonic systems. Science 154: 604–612
Saunders JW, Fallon JF (1966) Cell death in morphogenesis. In: Locke M (ed), Major problems in developmental biology. Academic Press, New York, pp 289–314
Webster DA, Gross J (1970) Studies on possible mechanisms of programmed cell death in the chick embryo. Dev Biol 22: 157–184
Wyllie A (1994–1995) The patient and the cell. An appreciation of Sir Alastair Currie. In: Cancer Research Campaign scientific yearbook. Cancer Research Campaign, London, pp 6–9
Wyllie AH, Kerr JFR, Macaskill IAM, Currie AR (1973a) Adrenocortical cell deletion: the role of ACTH. J Pathol 111: 85–94
Wyllie AH, Kerr JFR, Currie AR (1973b) Cell death in the normal neonatal rat adrenal cortex. J Pathol 111: 255–261
Wyllie AH, Kerr JFR, Currie AR (1980) Cell death: the significance of apoptosis. Int Rev Cytol 68: 251–306
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Kerr, J.F.R. (1999). A Personal Account of Events Leading to the Definition of the Apoptosis Concept. In: Kumar, S. (eds) Apoptosis: Biology and Mechanisms. Results and Problems in Cell Differentiation, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69184-6_1
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DOI: https://doi.org/10.1007/978-3-540-69184-6_1
Publisher Name: Springer, Berlin, Heidelberg
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