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Epigenetic Control of Gene Expression

  • Chapter
Genomic Imprinting

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 25))

Abstract

Epigenetics refers to changes in gene expression without change in nucleotide sequence. Genes destined to be silenced should be marked by an epigenetic signal, leading to the establishment of a heritable but potentially reversible inactive conformation of the gene. A large body of experimental data, that has been accumulated in the last two decades or so, clearly indicates that epigenetic control of gene expression in mammals is achieved by DNA methylation combined with chromatin structure.

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Authors and Affiliations

  1. Department of Cellular Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, 91120, Israel

    Aharon Razin & Ruth Shemer

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  1. Aharon Razin
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  2. Ruth Shemer
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  1. Dept. of Animal Development and Genetics, University of Uppsala, Norbyvägen 18 A, 75236, Uppsala, Sweden

    Rolf Ohlsson

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© 1999 Springer-Verlag Berlin Heidelberg

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Razin, A., Shemer, R. (1999). Epigenetic Control of Gene Expression. In: Ohlsson, R. (eds) Genomic Imprinting. Results and Problems in Cell Differentiation, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69111-2_9

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  • DOI: https://doi.org/10.1007/978-3-540-69111-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21956-0

  • Online ISBN: 978-3-540-69111-2

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