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Polycomb Silencing and the Maintenance of Stable Chromatin States

  • Chapter
Genomic Imprinting

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 25))

Abstract

In the course of development, the expression pattern of many genes is regulated, refined, and restricted to generate differential distributions of gene expression essential for the patterning, morphogenesis and allocation of cellular identities in different parts of the embryo. These patterns are produced by the interaction of multiple transcription factors, repressor and activators present in different parts of the embryo or induced by diffusible factors or cell-cell communication. The signals are often transient, since they depend on the situations existing at the time developmental decisions are made, yet the ensuing pattern of gene expression, characteristic of different determined states, must be maintained in later development by the tissues and the cells that constitute them.

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  1. Department of Zoology, University of Geneva, 30 quai Ernest Ansermet, CH1211, Geneva, Switzerland

    Vincenzo Pirrotta

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  1. Dept. of Animal Development and Genetics, University of Uppsala, Norbyvägen 18 A, 75236, Uppsala, Sweden

    Rolf Ohlsson

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Pirrotta, V. (1999). Polycomb Silencing and the Maintenance of Stable Chromatin States. In: Ohlsson, R. (eds) Genomic Imprinting. Results and Problems in Cell Differentiation, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69111-2_10

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  • DOI: https://doi.org/10.1007/978-3-540-69111-2_10

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