Skip to main content
SpringerLink
Log in

Stem Cells as a Treatment for Chronic Liver Disease and Diabetes

  • Chapter
Bone Marrow-Derived Progenitors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 180))

Abstract

Advances in stem cell biology and the discovery of pluripotent stem cells have made the prospect of cell therapy and tissue regeneration a clinical reality. Cell therapies hold great promise to repair, restore, replace or regenerate affected organs and may perform better than any pharmacological or mechanical device. There is an accumulating body of evidence supporting the contribution of adult stem cells, in particular those of bone marrow origin, to liver and pancreatic islet cell regeneration. In this review, we will focus on the cell therapy for the diseased liver and pancreas by adult haematopoietic stem cells, as well as their possible contribution and application to tissue regeneration. Furthermore, recent progress in the generation, culture and targeted differentiation of human haematopoietic stem cells to hepatic and pancreatic lineages will be discussed. We will also explore the possibility that stem cell technology may lead to the development of clinical modalities for human liver disease and diabetes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J, Wright NA (2000) Hepatocytes from non-hepatic adult stem cells. Nature 406:257

    Article  PubMed  CAS  Google Scholar 

  • am Esch JS 2nd, Knoefel WT, Klein M, Ghodsizad A, Fuerst G, Poll LW, Piechaczek C, Burchardt ER, Feifel N, Stoldt V, Stockschlader M, Stoecklein N, Tustas RY, Eisenberger CF, Peiper M, Haussinger D, Hosch SB (2005) Portal application of autologous CD133+ bone marrow cells to the liver: a novel concept to support hepatic regeneration. Stem Cells 23:463–470

    Article  Google Scholar 

  • Assmus B, Schachinger V, Teupe C, Britten M, Lehmann R, Dobert N, Grunwald F, Aicher A, Urbich C, Martin H, Hoelzer D, Dimmeler S, Zeiher AM (2002) Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCAREAMI). Circulation 106:3009–3017

    Article  PubMed  Google Scholar 

  • Banerjee M, Kumar A, Bhonde RR (2005) Reversal of experimental diabetes by multiple bone marrow transplantation. Biochem Biophys Res Commun 328:318–325

    Article  PubMed  CAS  Google Scholar 

  • Bianco P, Riminucci M, Gronthos S, Robey PG (2001) Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19:180–192

    Article  PubMed  CAS  Google Scholar 

  • Block GD, Locker J, Bowen WC, Petersen BE, Katyal S, Strom SC, Riley T, Howard TA, Michalopoulos GK (1996) Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium. J Cell Biol 132:1133–1149

    Article  PubMed  CAS  Google Scholar 

  • Bonner-Weir S, Weir GC (2005) New sources of pancreatic beta-cells.Nat Biotechnol 23:857–861

    Article  CAS  Google Scholar 

  • Burns CJ, Persaud SJ, Jones PM (2004) Stem cell therapy for diabetes: do we need to make beta cells? J Endocrinol 183:437–443

    Article  PubMed  CAS  Google Scholar 

  • Choi JB, Uchino H, Azuma K, Iwashita N, Tanaka Y, Mochizuki H, Migita M, Shimada T, Kawamori R, Watada H (2003) Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 46:1366–1374

    Article  PubMed  CAS  Google Scholar 

  • D’Ippolito G, Diabira S, Howard GA, Menei P, Roos BA, Schiller PC (2004)Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential. J Cell Sci 117:2971–2981

    Article  PubMed  CAS  Google Scholar 

  • Dahlke MH, Popp FC, Bahlmann FH, Aselmann H, Jager MD, Neipp M, Piso P, Klempnauer J, Schlitt HJ (2003) Liver regeneration in a retrorsine/CCl4-induced acute liver failure model: do bone marrow-derived cells contribute? J Hepatol 39:365–373

    Article  PubMed  CAS  Google Scholar 

  • Daneman D (2006) Type 1 diabetes. Lancet 367:847–858

    Article  PubMed  CAS  Google Scholar 

  • Devendra D, Liu E, Eisenbarth GS (2004) Type 1 diabetes: recent developments. BMJ 328:750–754

    Article  PubMed  Google Scholar 

  • Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41–46

    Article  PubMed  CAS  Google Scholar 

  • Ende N, Chen R, Reddi AS (2004) Effect of human umbilical cord blood cells on glycemia and insulitis in type 1 diabetic mice. Biochem Biophys Res Commun 325:665–669

    Article  PubMed  CAS  Google Scholar 

  • Fallowfield JA, Iredale JP (2004) Targeted treatments for cirrhosis. Expert Opin Ther Targets 8:423–435

    Article  PubMed  CAS  Google Scholar 

  • Fang TC, Alison MR, Wright NA, Poulsom R (2004) Adult stem cell plasticity:will engineered tissues be rejected? Int J Exp Pathol 85:115–124

    Article  PubMed  CAS  Google Scholar 

  • Fernandez Vina R, Andrin O, Saslavsky J, Ferreyra de Silva J, Vrsalovick F, Camozzi L, Ferreyra O, D Adamo C, Foressi F, Fernandez Vina R, Clasen A (2006a) Increase of ‘c’ peptide level in type 1 diabetics patients after direct pancreas implant by endovascular way of autologous adult mononuclear CD34+CD38(−) cells (Teceldiab 2 study). In: 4th International Society for Stem Cell Research Annual Meeting, Toronto

    Google Scholar 

  • Fernandez Vina R, Saslavsky J, Andrin O, Vrsalovick F, Ferreyra de Silva J, Ferreyra O, Camozzi L, Foressi F, D Adamo C, Fernandez Vina R (2006b) First word reported data from Argentina of implant and cellular therapy with autologous adult stem cells in type 2 diabetic patients (Teceldiar study 1). In: 4th International Society for Stem Cell Research Annual Meeting, Toronto

    Google Scholar 

  • Fiegel HC, Lioznov MV, Cortes-Dericks L, Lange C, Kluth D, Fehse B, Zander AR (2003) Liver-specific gene expression in cultured human hematopoietic stem cells. Stem Cells 21:98–104

    Article  PubMed  CAS  Google Scholar 

  • Fodor WL (2003) Tissue engineering and cell based therapies, from the bench to the clinic: the potential to replace, repair and regenerate. Reprod Biol Endocrinol 1:102

    Article  PubMed  Google Scholar 

  • Fogt F, Beyser KH, Poremba C, Zimmerman RL, Khettry U, Ruschoff J (2002) Recipient-derived hepatocytes in liver transplants: a rare event in sex-mismatched transplants. Hepatology 36:173–176

    Article  PubMed  Google Scholar 

  • Frankel MS (2000) In search of stem cell policy. Science 287:1397

    Article  PubMed  CAS  Google Scholar 

  • Gordon MY, Levičar N, Pai M, Bachellier P, Dimarakis I, Al-Allaf F, M’Hamdi H, Thalji T, Welsh JP, Marley SB, Davis J, Dazzi F, Marelli-Berg F, Tait P, Playford R, Jiao L, Jensen S, Nicholls JP, Ayav A, Nohandani M, Farzaneh F, Gaken J, Dodge R, Alison M, Apperley JF, Lechler R, Habib NA (2006) Characterisation and clinical application of human CD34+ stem/progenitor cell populations mobilised into the blood by G-CSF. Stem Cells 24:1822–1830

    Article  PubMed  Google Scholar 

  • Grompe M, Lindstedt S, al-Dhalimy M, Kennaway NG, Papaconstantinou J, Torres-Ramos CA, Ou CN, Finegold M (1995) Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat Genet 10:453–460

    Article  PubMed  CAS  Google Scholar 

  • Gussoni E, Soneoka Y, Strickland CD, Buzney EA, Khan MK, Flint AF, Kunkel LM, Mulligan RC (1999) Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 401:390–394

    PubMed  CAS  Google Scholar 

  • Halvorsen TL, Beattie GM, Lopez AD, Hayek A, Levine F (2000) Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol 166:103–109

    Article  PubMed  CAS  Google Scholar 

  • Heng BC, Yu H, Yin Y, Lim SG, Cao T (2005) Factors influencing stem cell differentiation into the hepatic lineage in vitro. J Gastroenterol Hepatol 20:975–987

    Article  PubMed  Google Scholar 

  • Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B, Thyssen S, Gray DA, Bhatia M (2003) Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 21:763–770

    Article  PubMed  CAS  Google Scholar 

  • Ianus A, Holz GG, Theise ND, Hussain MA (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111:843–850

    Article  PubMed  CAS  Google Scholar 

  • International Diabetes Federation (2006) Diabetes atlas. In: http://www.eatlas.idf.org/. Cited 23 Dec 2009

    Google Scholar 

  • Jang YY, Collector MI, Baylin SB, Diehl AM, Sharkis SJ (2004) Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 6:532–539

    Article  PubMed  CAS  Google Scholar 

  • Kanazawa Y, Verma IM (2003) Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver. Proc Natl Acad Sci USA 100[Suppl 1]:11850–11853

    Article  PubMed  CAS  Google Scholar 

  • Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, Champlin RE, Estrov Z (2002) Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 346:738–746

    Article  PubMed  Google Scholar 

  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ (2001) Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105:369–377

    Article  PubMed  CAS  Google Scholar 

  • Kucia M, Ratajczak J, Reca R, Janowska-Wieczorek A, Ratajczak MZ (2004) Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury. Blood Cells Mol Dis 32:52–57

    Article  PubMed  CAS  Google Scholar 

  • Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL, Grompe M (2000) Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6:1229–1234

    Article  PubMed  CAS  Google Scholar 

  • Lammert E, Cleaver O, Melton D (2001) Induction of pancreatic differentiation by signals from blood vessels. Science 294:564–567

    Article  PubMed  CAS  Google Scholar 

  • Lechner A, Habener JF (2003) Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am J Physiol Endocrinol Metab 284:E259–E266

    PubMed  CAS  Google Scholar 

  • Lechner A, Yang YG, Blacken RA, Wang L, Nolan AL, Habener JF (2004) No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 53:616–623

    Article  PubMed  CAS  Google Scholar 

  • Lee KD, Kuo TK, Whang-Peng J, Chung YF, Lin CT, Chou SH, Chen JR, Chen YP, Lee OK (2004) In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40:1275–1284

    Article  PubMed  CAS  Google Scholar 

  • Lee VM, Stoffel M (2003) Bone marrow: an extra-pancreatic hideout for the elusive pancreatic stem cell? J Clin Invest 111:799–801

    Article  PubMed  CAS  Google Scholar 

  • Li L, Xie T (2005) Stem cell niche: structure and function. Annu Rev Cell Dev Biol 21:605–631

    Article  PubMed  CAS  Google Scholar 

  • Mallet VO, Mitchell C, Mezey E, Fabre M, Guidotti JE, Renia L, Coulombel L, Kahn A, Gilgenkrantz H (2002) Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo. Hepatology 35:799–804

    Article  PubMed  Google Scholar 

  • Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA (2004) Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes 53:91–98

    Article  PubMed  CAS  Google Scholar 

  • Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR (2000) Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290:1779–1782

    Article  PubMed  CAS  Google Scholar 

  • Michalopoulos GK, Bowen WC, Mule K, Luo J (2003) HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. Gene Expr 11:55–75

    PubMed  CAS  Google Scholar 

  • Ministry of Health (2001) Annual report of the chief medical officer. In: Ministry of Health Report, UK, London

    Google Scholar 

  • Misawa R, Ise H, Takahashi M, Morimoto H, Kobayashi E, Miyagawa S, Ikeda U (2006) Development of liver regenerative therapy using glycoside-modified bone marrow cells. Biochem Biophys Res Commun 342:434–440

    Article  PubMed  CAS  Google Scholar 

  • Miyazaki M, Akiyama I, Sakaguchi M, Nakashima E, Okada M, Kataoka K, Huh NH (2002) Improved conditions to induce hepatocytes from rat bone marrow cells in culture. Biochem Biophys Res Commun 298:24–30

    Article  PubMed  CAS  Google Scholar 

  • Moriscot C, de Fraipont F, Richard MJ, Marchand M, Savatier P, Bosco D, Favrot M, Benhamou PY (2005) Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells 23:594–603

    Article  PubMed  CAS  Google Scholar 

  • Najimi M, Sokal E (2005) Liver cell transplantation. Minerva Pediatr 57:243–257

    PubMed  CAS  Google Scholar 

  • Ng IO, Chan KL, Shek WH, Lee JM, Fong DY, Lo CM, Fan ST (2003) High frequency of chimerism in transplanted livers. Hepatology 38:989–998

    PubMed  Google Scholar 

  • Oh SH, Miyazaki M, Kouchi H, Inoue Y, Sakaguchi M, Tsuji T, Shima N, Higashio K, Namba M (2000) Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun 279:500–504

    Article  PubMed  CAS  Google Scholar 

  • Oh SH, Muzzonigro TM, Bae SH, LaPlante JM, Hatch HM, Petersen BE (2004) Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 84:607–617

    Article  PubMed  CAS  Google Scholar 

  • Ohashi K, Park F, Kay MA (2001) Hepatocyte transplantation: clinical and experimental application. J Mol Med 79:617–630

    Article  PubMed  CAS  Google Scholar 

  • Okumoto K, Saito T, Hattori E, Ito JI, Adachi T, Takeda T, Sugahara K, Watanabe H, Saito K, Togashi H, Kawata S (2003) Differentiation of bone marrow cells into cells that express liver-specific genes in vitro: implication of the Notch signals in differentiation. Biochem Biophys Res Commun 304:691–695

    Article  PubMed  CAS  Google Scholar 

  • Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P (2001) Bone marrow cells regenerate infarcted myocardium. Nature 410:701–705

    Article  PubMed  CAS  Google Scholar 

  • Pessina A, Eletti B, Croera C, Savalli N, Diodovich C, Gribaldo L (2004) Pancreas developing markers expressed on human mononucleated umbilical cord blood cells. Biochem Biophys Res Commun 323:315–322

    Article  PubMed  CAS  Google Scholar 

  • Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS, Goff JP (1999) Bone marrow as a potential source of hepatic oval cells. Science 284:1168–1170

    Article  PubMed  CAS  Google Scholar 

  • Petersen KF, Shulman GI (2006) Etiology of insulin resistance. Am J Med 119:S10–S16

    Article  PubMed  CAS  Google Scholar 

  • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147

    Article  PubMed  CAS  Google Scholar 

  • Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Del Carro U, Amadio S, Bergami A, Furlan R, Comi G, Vescovi AL, Martino G (2003) Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422:688–694

    Article  PubMed  CAS  Google Scholar 

  • Preston SL, Alison MR, Forbes SJ, Direkze NC, Poulsom R, Wright NA (2003) The new stem cell biology: something for everyone. Mol Pathol 56:86–96

    Article  PubMed  CAS  Google Scholar 

  • Ratajczak MZ, Kucia M, Reca R, Majka M, Janowska-Wieczorek A, Ratajczak J (2004) Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells ‘hide out’ in the bone marrow. Leukemia 18:29–40

    Article  PubMed  CAS  Google Scholar 

  • Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 18:399–404

    Article  PubMed  CAS  Google Scholar 

  • Ruhnke M, Ungefroren H, Nussler A, Martin F, Brulport M, Schormann W, Hengstler JG, Klapper W, Ulrichs K, Hutchinson JA, Soria B, Parwaresch RM, Heeckt P, Kremer B, Fandrich F (2005) Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells. Gastroenterology 128:1774–1786

    Article  PubMed  CAS  Google Scholar 

  • Ryan EA, Lakey JR, Paty BW, Imes S, Korbutt GS, Kneteman NM, Bigam D, Rajotte RV, Shapiro AM (2002) Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 51:2148–2157

    Article  PubMed  CAS  Google Scholar 

  • Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H, Okita K (2004) Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology 40:1304–1311

    Article  PubMed  Google Scholar 

  • Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu WS, Verfaillie CM (2002) Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 109:1291–1302

    Article  PubMed  CAS  Google Scholar 

  • Sell S (2001) Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 33:738–750

    Article  PubMed  CAS  Google Scholar 

  • Sipione S, Eshpeter A, Lyon JG, Korbutt GS, Bleackley RC (2004) Insulin expressing cells from differentiated embryonic stem cells are not beta cells. Diabetologia 47:499–508

    Article  PubMed  CAS  Google Scholar 

  • Taneera J, Rosengren A, Renstrom E, Nygren JM, Serup P, Rorsman P, Jacobsen SE (2006) Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes 55:290–296

    Article  PubMed  CAS  Google Scholar 

  • Tang DQ, Cao LZ, Burkhardt BR, Xia CQ, Litherland SA, Atkinson MA, Yang LJ (2004) In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 53:1721–1732

    Article  PubMed  CAS  Google Scholar 

  • Terai S, Sakaida I, Yamamoto N, Omori K, Watanabe T, Ohata S, Katada T, Miyamoto K, Shinoda K, Nishina H, Okita K (2003) An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J Biochem (Tokyo) 134:551–558

    Article  PubMed  CAS  Google Scholar 

  • Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y, Uchida K, Yamasaki T, Fujii Y, Okita K, Sakaida I (2006) Improved liver function in liver cirrhosis patients after autologous bone marrow cell infusion therapy. Stem Cells 24:2292–2298

    Article  PubMed  CAS  Google Scholar 

  • Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS (2000a) Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 31:235–240

    Article  PubMed  CAS  Google Scholar 

  • Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS (2000b) Liver from bone marrow in humans. Hepatology 32:11–16

    Article  PubMed  CAS  Google Scholar 

  • Till JE, McCulloch E (1961) A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213–222

    Article  PubMed  CAS  Google Scholar 

  • Vig P, Russo FP, Edwards RJ, Tadrous PJ, Wright NA, Thomas HC, Alison MR, Forbes SJ (2006) The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice. Hepatology 43:316–324

    Article  PubMed  Google Scholar 

  • Wagers AJ, Sherwood RI, Christensen JL, Weissman IL (2002) Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297:2256–2259

    Article  PubMed  CAS  Google Scholar 

  • Wang X, Ge S, McNamara G, Hao QL, Crooks GM, Nolta JA (2003) Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood 101:4201–4208

    Article  PubMed  CAS  Google Scholar 

  • Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, Fichtner S, Korte T, Hornig B, Messinger D, Arseniev L, Hertenstein B, Ganser A, Drexler H (2004) Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364:141–148

    Article  PubMed  Google Scholar 

  • Wu T, Cieply K, Nalesnik MA, Randhawa PS, Sonzogni A, Bellamy C, Abu-Elmagd K, Michalopolous GK, Jaffe R, Kormos RL, Gridelli B, Fung JJ, Demetris AJ (2003) Minimal evidence of transdifferentiation from recipient bone marrow to parenchymal cells in regenerating and long-surviving human allografts. Am J Transplant 3:1173–1181

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Oncology and Technology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

    N. Levičar, I. Dimarakis, J. Tracey & N. A. Habib

  2. Department of Haematology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK

    C. Flores & M. Y. Gordon

Authors
  1. N. Levičar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Dimarakis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Flores
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Tracey
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Y. Gordon
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. A. Habib
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. Levičar .

Editor information

Editors and Affiliations

  1. Cardiovascular Disease Boehringer Ingelheim, Pharmaceuticals, Inc., 175 Briar Ridge Road, Ridgefield, CT, 06877, USA

    Katalin Kauser MD, PhD, DSc (Director) (Director)

  2. Department of Internal Medicine III, University of Frankfurt, Theodor-Stern-Kai 7, D-60590, Frankfurt a. Main

    Andreas-Michael Zeiher MD (Professor Molecular Cardiology) (Professor Molecular Cardiology)

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Levičar, N., Dimarakis, I., Flores, C., Tracey, J., Gordon, M.Y., Habib, N.A. (2007). Stem Cells as a Treatment for Chronic Liver Disease and Diabetes. In: Kauser, K., Zeiher, AM. (eds) Bone Marrow-Derived Progenitors. Handbook of Experimental Pharmacology, vol 180. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68976-8_11

Download citation

Publish with us

Policies and ethics

Search

Navigation