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Bone and Soft Tissue Tumours

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Book cover Measurements in Musculoskeletal Radiology

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Much of the use of imaging in the detection, diagnosis and management of bone and soft tissue tumours relies on evaluation of morphological changes. There are, however, a number of situations where particular measurements derived from different imaging techniques can be of considerable value in predicting fracture risk, planning surgery and assessing response to treatment. The purpose of this chapter is to review these different applications.

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References

  • Abudu A, Davies AM, Pynsent PB, Mangham DC, Tillman RM, Carter SR, Grimer RJ (1999) Tumour volume as a predictor of necrosis after chemotherapy in Ewing’s sarcoma. J Bone Joint Surg Br 81B:317–322

    Article  Google Scholar 

  • Ahn JI, Park JS (1994) Pathological fractures secondary to unicameral bone cysts. Int Orthop 18:20–22

    Article  CAS  PubMed  Google Scholar 

  • Arata MA, Peterson HA, Dahlin DC (1981) Pathological fractures through nonossifying fibromas. J Bone Joint Surg Am 63A:980–988

    Article  Google Scholar 

  • Ashford RU, Pendlebury S, Stalley PD (2006) Management of metastatic disease of the appendicular skeleton. Curr Orthop 20:299–315

    Article  Google Scholar 

  • de Baere T, Vanel D, Shapeero L, Charpentier A, Terrier P, di Paola M (1992) Osteosarcoma after chemotherapy: evaluation with contrast material enhanced subtraction MR imaging. Radiology 185:587–592

    Article  PubMed  Google Scholar 

  • Bajpai J, Gamnagatti S, Kumar R, Sreenivas V, Sharma MC, Khan SA, Rastogi S, Malhotra A, Safaya R, Bakhshi S (2011) Role of MRI in osteosarcoma for evaluation and prediction of chemotherapy response: correlation with histological necrosis. Pediatr Radiol 41:441–450

    Article  PubMed  Google Scholar 

  • Baur A, Stabler A, Bruning R, Bartl R, Krodel A, Reiser M, Deimling M (1998) Diffusion-weighted MR imaging of bone marrow: differentiation of benign versus pathologic compression fractures. Radiology 207:349–356

    Article  CAS  PubMed  Google Scholar 

  • Baur A, Reiser MF (2000) Diffusion-weighted imaging of the musculoskeletal system in humans. Skelet Radiol 29:555–562

    Article  CAS  Google Scholar 

  • Benz MR, Czernin J, Allen-Auerbach MS, Tap WD, Dry SM, Elashoff D, Chow K, Evilevitch V, Eckardt JJ, Phelps ME, Weber WA, Eilber FC (2009) FDG-PET/CT imaging predicts histopathologic treatment responses after the initial cycle of neoadjuvant chemotherapy in high-grade soft-tissue sarcomas. Clin Cancer Res 15:2856–2863

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bernard SA, Murphey MD, Flemming DJ, Kransdorf MJ (2010) Improved differentiation of benign osteochon- dromas from secondary chondrosarcomas with standardized measurement of cartilage cap at CT and MR imaging. Radiology 255:857–865

    Article  PubMed  Google Scholar 

  • Berquist TH, Ehman RL, King BF, Hodgman CH, Ilstrup DM (1990) Value of MR imaging in differentiating benign from malignant soft tissue masses: a study of 95 lesions. Am J Roentgenol 155:1251–1255

    Article  CAS  Google Scholar 

  • Berquist TH (1993) MR imaging of primary skeletal neoplasms. Radiol Clin N Am 31:411–424

    CAS  PubMed  Google Scholar 

  • Bloem JL, Taminiau AHM, Eulderink F, Hermans J, Pauwels EKJ (1988) Radiologic staging of primary bone sarcoma: MR imaging, scintigraphy, angiography, and CT correlated with pathologic examination. Radiology 169:805–810

    Article  CAS  PubMed  Google Scholar 

  • Bonnerot V, Charpentier A, Frouin F, Kalifa C, Vanel D, Di Paola R (1992) Factor analysis of dynamic MR imaging in predicting response of osteosarcoma to chemotherapy. Investig Radiol 27:847–855

    Article  CAS  Google Scholar 

  • Cheon GJ, Kim MS, Lee JA, Lee SY, Cho WH, Song WS, Koh JS, Yoo JY, Oh DH, Shin DS, Jeon DG (2009) Prediction model of chemotherapy response in osteosarcoma by 18F-FDG PET and MRI. J Nucl Med 50:1435–1440

    Article  CAS  PubMed  Google Scholar 

  • Costelloe CM, Macapinlac HA, Madewell JE, Fitzgerald NE, Mawlawi OR, Rohren EM, Raymond AK, Lewis VO, Anderson PM, Bassett RL Jr, Harrell RK, Marom EM (2009) 18F-FDG PET/CT as an indicator of progression-free and overall survival in osteosarcoma. J Nucl Med 50:340–347

    Article  PubMed  Google Scholar 

  • Damron TA, Morgan H, Prakash D, Grant W, Aronowitz J, Heiner J (2003) Critical evaluation of Mirels’ rating system for impending pathologic fractures. Clin Orthop 415S:S201–S207

    Article  Google Scholar 

  • Damron TA, Ward WG (2003) Risk of pathologic fracture: assessment. Clin Orthop 415S:S208–S211

    Article  Google Scholar 

  • De Coninck T, Jans L, Sys G, Huysse W, Verstraeten T, Forsyth R, Poffyn B, Verstraete K (2013) Dynamic contrast-enhanced MR imaging for differentiation between enchondroma and chondrosarcoma. Eur Radiol 2013(23):3140–3152

    Article  Google Scholar 

  • Dijkstra PD, Oudkerk M, Wiggers T (1997) Prediction of pathological subtrochanteric fractures due to metastatic lesions. Arch Orthop Trauma Surg 116:221–224

    Article  CAS  PubMed  Google Scholar 

  • Douis H, Jeys L, Grimer R, Davies AM (2014) Is there a role for Diffusion-Weighted MRI (DWI) in the diagnosis of central cartilage tumours? Skelet Radiol 43:1347

    Google Scholar 

  • Dyke JP, Panicek DM, Healey JH, Meyers PA, Huvos AG, Schwartz LH, Thaler HT, Tofts PS, Gorlick R, Koutcher JA, Ballon D (2003) Osteogenic and Ewing sarcomas: estimation of necrotic fraction during induction chemotherapy with dynamic contrast-enhanced MR imaging. Radiology 228:271–278

    Article  PubMed  Google Scholar 

  • Easley ME, Kneisl JS (1997) Pathologic fractures through nonossifying fibromas: is prophylactic treatment warranted. J Pediatr Orthop 17:808–813

    CAS  PubMed  Google Scholar 

  • Einarsdóttir H, Karlsson M, Wejde J, Bauer HC (2004) Diffusion-weighted MRI of soft tissue tumours. Eur Radiol 14:959–963

    Article  PubMed  Google Scholar 

  • Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop (153):106–120

    Google Scholar 

  • Erlemann R, Reiser M, Peters P, Vasallo P, Nommensen B, Kusnierz-Glaz CR, Ritter J, Roessner A (1989) Musculoskeletal neoplasms: static and dynamic Gd-DTPA enhanced MR imaging. Radiology 171:767–773

    Article  CAS  PubMed  Google Scholar 

  • Erlemann R, Sciuk J, Bosse A et al (1990) Response of osteosarcoma and Ewing’s sarcoma to preoperative chemotherapy: assessment with dynamic and static MR imaging and skeletal scintigraphy. Radiology 175:791–796

    Article  CAS  PubMed  Google Scholar 

  • Erlemann R, Sciuk J, Wuisman P et al (1992) Dynamic MR tomography in diagnosis of inflammatory and tumourous space-occupying growths of the musculoskeletal system. Rofo 156:353–359

    Article  CAS  PubMed  Google Scholar 

  • Estes DN, Magill HL, Thompson EI, Hayes FA (1990) Primary Ewing sarcoma; follow-up with Ga-67 scintigraphy. Radiology 177:449–453

    Article  CAS  PubMed  Google Scholar 

  • Evilevitch V, Weber WA, Tap WD, Allen-Auerbach M, Chow K, Nelson SD, Eilber FR, Eckardt JJ, Elashoff RM, Phelps ME, Czernin J, Eilber FC (2008) Reduction of glucose metabolic activity is more accurate than change in size at predicting histopathologic response to neoadjuvant therapy in high-grade soft-tissue sarcomas. Clin Cancer Res 14:715–720

    Article  CAS  PubMed  Google Scholar 

  • Fidler M (1973) Prophylactic internal fixation of secondary neoplastic deposits in long bones. Br Med J 1:341–343

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fidler M (1981) Incidence of fracture through metastases in long bones. Acta Orthop Scand 52:623–627

    Article  CAS  PubMed  Google Scholar 

  • Fletcher BD (1991) Response of osteosarcoma and Ewing sarcoma to chemotherapy: imaging evaluation. Am J Roentgenol 157:825–833

    Article  CAS  Google Scholar 

  • Fletcher BD, Hanna SL, Fairclough DL, Gronmeyer SA (1992) Pediatric musculoskeletal tumors: use of dynamic contrast-enhanced MR imaging to monitor response to chemotherapy. Radiology 184:243–248

    Article  CAS  PubMed  Google Scholar 

  • Franzius C, Sciuk J, Brinkschmidt C et al (2000) Evaluation of chemotherapy response in primary bone tumors with F-18 FDG positron emission tomography with histologically assessed tumor necrosis. Clin Nucl Med 25:874–881

    Article  CAS  PubMed  Google Scholar 

  • Gielen JMLA, De Schepper AM, Vanhoenacker F, Parizel P, Wang XL, Sciot R, Weyler J (2004) Accuracy of MRI in characterization of soft tissue tumors and tumor-like lesions. A prospective study in 548 patients. Eur Radiol 14:2320–2330

    Article  PubMed  Google Scholar 

  • Giernaerdt MJA, Hogendoorn PCW, Bloem JL, Taminiau AHM, van der Woude HJ (2000) Cartilaginous tumors: fast contrast-enhanced MR imaging. Radiology 214:539–546

    Article  Google Scholar 

  • Gillespy T, Manfrini M, Ruggieri P, Spanier SS, Pettersson H, Springfield DS (1988) Staging of intraosseous extent of osteosarcoma: correlation of preoperative CT with pathologic macroslides. Radiology 167:765–767

    Article  PubMed  Google Scholar 

  • Greene FL, Page DL, Fleming ID (eds) (2002a) American joint committee on cancer. Bone, 6th edn. Springer-Verlag, New York, NY, pp 213–219

    Google Scholar 

  • Greene FL, Page DL, Fleming ID (eds) (2002b) American Joint Committee on Cancer. Soft tissue, 6th edn. Springer-Verlag, New York, NY, pp 193–197

    Google Scholar 

  • Greer RJ, Woodruff J, Casper ES et al (1992) Management of small soft tissue sarcoma of the extremity in adults. Arch Surg 127:1285–1289

    Article  Google Scholar 

  • Griffith JF, Chan DPN, Kumta SM, Chow LTC, Ahuja AT (2004) Does Doppler analysis of musculoskeletal soft tissue tumours help predict tumour malignancy? Clin Radiol 59:369–375

    Article  CAS  PubMed  Google Scholar 

  • Guo J, Reddick WE, Glass JO, Ji Q, Billups CA, Wu J, Hoffer FA, Kaste SC, Jenkins JJ, Ortega Flores XC, Quintana J, Villarroel M, Daw NC (2012) Dynamic contrast-enhanced magnetic resonance imaging as a prognostic factor in predicting event-free and overall survival in pediatric patients with osteosarcoma. Cancer 118:3776–3885

    Article  PubMed  Google Scholar 

  • Hamada K, Tomita Y, Inoue A, Fujimoto T, Hashimoto N, Myoui A, Yoshikawa H, Hatazawa J (2009) Evaluation of chemotherapy response in osteosarcoma with FDG-PET. Ann Nucl Med 23:89–95

    Article  CAS  PubMed  Google Scholar 

  • Hanna SL, Parham DM, Fairclough DL, Meyer WH, Lee AH, Fletcher BD (1992) Assessment of osteosarcoma response to preoperative chemotherapy using dynamic FLASH gadolinium-DTPA-enhanced MR mapping. Investig Radiol 27:367–373

    Article  CAS  Google Scholar 

  • Harrington KD (1982) New trends in management of lower extremity metastases. Clin Orthop 169:53–61

    Google Scholar 

  • Hawkins DS, Rajendran YG, Conrad EU, Bruckner JD, Eary JF (2002) Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography. Cancer 94:3277–3284

    Article  CAS  PubMed  Google Scholar 

  • Hawkins DS, Schuetze SM, Butrynski YE, Rajendran YG, Vernon CB, Conrad EU, Eary JF (2005) [F-18]-fluorodeoxy-D-glucose positron emission tomography predicts outcome for Ewing sarcoma family of tumors. J Clin Oncol 23:8828–8833

    Article  PubMed  Google Scholar 

  • Hawkins DS, Conrad EU 3rd, Butrynski JE, Schuetze SM, Eary JF (2009) [F-18]-fluorodeoxy-D-glucose-positron emission tomography response is associated with outcome for extremity osteosarcoma in children and young adults. Cancer 115:3519–3525

    Article  PubMed  Google Scholar 

  • Hayashida Y, Hirai T, Yakushiji T, Katahira K, Shimomura O, Imuta M, Nakaura T, Utsunomiya D, Awai K, Yamashita Y (2006a) Evaluation of diffusion-weighted imaging for the differential diagnosis of poorly contrast-enhanced and T2-prolonged bone masses: initial experience. J Magn Reson Imaging 23:377–382

    Article  PubMed  Google Scholar 

  • Hayashida Y, Yakushiji T, Awai K, Katahira K, Nakayama Y, Shimomura O, Kitajima M, Hirai T, Yamashita Y, Mizuta H (2006b) Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: initial results. Eur Radiol 16:2637–2643

    Article  PubMed  Google Scholar 

  • Heck RK, Stacy GS, Flaherty MJ, Montag AG, Peabody TD, Simon MA (2003) A comparison study of staging systems for bone sarcomas. Clin Orthop 415:64–71

    Article  Google Scholar 

  • Hipp JA, Springfield DS, Hayes WC (1995) Predicting pathologic fracture risk in the management of metastatic bone defects. Clin Orthop 312:120–135

    Google Scholar 

  • Kaelin AJ, MacEwen GD (1989) Unicameral bone cysts: natural history and the risk of fracture. Int Orthop 13:275–282

    Article  CAS  PubMed  Google Scholar 

  • Kenney PJ, Gilula LA, Murphy WA (1981) The use of computed tomography to distinguish osteochondroma and chondrosarcoma. Radiology 139:129–137

    Article  CAS  PubMed  Google Scholar 

  • Kim MS, Lee SY, Cho WH, Song WS, Koh JS, Lee JA, Yoo JY, Jeon DG (2008) Initial tumor size predicts histologic response and survival in localized osteosarcoma patients. J Surg Oncol 97:456–461

    Article  PubMed  Google Scholar 

  • Knop J, Delling G, Heise U, Winkler K (1990) Scintigraphic evaluation of tumour regression during preoperative chemotherapy of osteosarcoma. Skelet Radiol 19:165–172

    Article  CAS  Google Scholar 

  • Kong CB, Byun BH, Lim I, Choi CW, Lim SM, Song WS, Cho WH, Jeon DG, Koh JS, Yoo JY, Lee SY (2013) 18F-FDG PET SUVmax as an indicator of histopathologic response after neoadjuvant chemotherapy in extremity osteosarcoma. Eur J Nucl Med Mol Imaging 40:728–736

    Article  CAS  PubMed  Google Scholar 

  • Lang P, Honda G, Roberts T, Vahlensieck M, Johnston JO, Rosenau W, Mathur A, Peterfy C, Gooding C, Genant HK (1995) Musculoskeletal neoplasm: perineoplastic edema versus tumor on dynamic postcontrast MR images with spatial mapping of instantaneous enhancement rates. Radiology 197:831–839

    Article  CAS  PubMed  Google Scholar 

  • Lawrence JA, Babyn P, Chan HSL, Thorner PS, Pron GE, Krajbich IJ (1993) Extremity osteosarcoma in childhood: prognostic value of radiologic imaging. Radiology 189:43–47

    Article  CAS  PubMed  Google Scholar 

  • Lecouvet FE, Malghem J, Michaux L, Michaux JL et al (1997) Vertebral compression fractures in multiple myeloma. Part II Assessment of fracture risk with MR imaging of spinal bone metastases. Radiology 204:201–205

    Article  CAS  PubMed  Google Scholar 

  • Lecouvet FE, Vande Berg BC, Michaux L, Jamart J et al (1998) Development of vertebral fractures in patients with multiple myeloma: does MRI enable recognition of vertebrae that will collapse? J Comput Assist Tomogr 22:430–436

    Article  CAS  PubMed  Google Scholar 

  • Van der Linden YM, Kroon HM, Dijkstra SP, Lok JJ, Noordijk EM, Leer JW, Marijnen CA, Dutch Bone Metastasis Study Group. Radiother Oncol. 2003 Oct;69(1):21–31. Simple radiographic parameter predicts fracturing in metastatic femoral bone lesions: results from a randomised trial

    Google Scholar 

  • Van der Linden YM, Kroon HM, Dijkstra SP, Lok JJ, Noordijk EM, Leer JW, Marijnen CA, Dutch Bone Metastasis Study Group. Radiother Oncol. 2003;69(1):21–31. Simple radiographic parameter predicts fracturing in metastatic femoral bone lesions: results from a randomised trial.

    Google Scholar 

  • Leong NL, Anderson ME, Gebhardt MC, Snyder BD (2010) Computed tomography-based structural analysis for predicting fracture risk in children with benign skeletal neoplasms: comparison of specificity with that of plain radiographs. J Bone Joint Surg Am 92:18277–11833

    Article  Google Scholar 

  • Lisle JW, Eary JF, O'Sullivan J, Conrad EU (2009) Risk assessment based on FDG-PET imaging in patients with synovial sarcoma. Clin Orthop Relat Res 467:1605–1611

    Article  PubMed  Google Scholar 

  • Liu PT, Chivers FP, Roberts CC, Schultz CJ, Beauchamp CP (2003) Imaging of osteoid osteoma with dynamic gadolinium-enhanced MR imaging. Radiology 227:691–700

    Article  PubMed  Google Scholar 

  • Ma LD, Frassica FJ, Scott WW Jr, Fishman EK, Zerhouni EA (1995) Differentiation of benign and malignant musculoskeletal tumors: potential pitfalls with MR imaging. Radiographics 15:349–366

    Article  CAS  PubMed  Google Scholar 

  • Maeda M, Matsumine A, Kato H, Kusuzaki K, Maier SE, Uchida A, Takeda K (2007) Soft-tissue tumors evaluated by line-scan diffusion-weighted imaging: influence of myxoid matrix on the apparent diffusion coefficient. J Magn Reson Imaging 25:1199–1204

    Article  PubMed  Google Scholar 

  • Mavrogenis AF, Pala E, Romantini M, Guerra G, Romagnoli C, Maccauro G, Ruggieri P (2011) Side effects in radiation in musculoskeletal oncology: clinical evaluation of radiation-induced fractures. Int J Immunopathol Pharmacol 24:29–37

    Article  PubMed  Google Scholar 

  • McAfee PC, Zdeblick TA (1989) Tumors of the thoracic and lumbar spine: surgical treatment via the anterior approach. J Spinal Disord 2:145–154

    Article  CAS  PubMed  Google Scholar 

  • Mirels H (1989) Metastatic disease in long bones: a proposed scoring system for diagnosing impending pathologic fractures. Clin Orthop 249:256–264

    Google Scholar 

  • Mirowitz SA, Tooty WG, Lee JKT (1992) Characterization of musculoskeletal masses using dynamic Gd-DTPA enhanced spin-ecgo MRI. J Comput Assist Tomogr 16:120–125

    CAS  PubMed  Google Scholar 

  • Morrison WB, Dalinka MK, Daffner RH et al (2005) Bone tumors. In: ACR appropriateness criteria. American College of Radiology, Reston, VA, pp 1–5

    Google Scholar 

  • Moulton JS, Blebea JS, Dunco DM, Braley SE, Bisset GS, Emery KH (1995) MR imaging of soft tissue masses: diagnostic efficacy and value of distinguishing between benign and malignant lesions. Am J Roentgenol 164:1191–1199

    Article  CAS  Google Scholar 

  • Nair N, Ali A, Green AA, Lamonica G, Alibazoglu H, Alibazoglu B, Hollinger EF, Ahmed K (2000) Response of osteosarcoma to chemotherapy. Evaluation with F-18 FDG-PET scans. Clin Positron Imaging 3:79–83

    Article  CAS  PubMed  Google Scholar 

  • O’Flanagan SJ, Stack JP, McGee HM, Dervan P, Hurson B (1991) Imaging of intramedullary tumour spread in osteosarcoma. A comparison of techniques. J Bone Joint Surg Br 73B:998–1001

    Article  Google Scholar 

  • Oka K, Yakushiji T, Sato H, Hirai T, Yamashita Y, Mizuta H (2010) The value of diffusion-weighted imaging for monitoring the chemotherapeutic response of osteosarcoma: a comparison between average apparent diffusion coefficient and minimum apparent diffusion coefficient. Skelet Radiol 39:141–146

    Article  Google Scholar 

  • Oka K, Yakushiji T, Sato H, Fujimoto T, Hirai T, Yamashita Y, Mizuta H (2011) Usefulness of diffusion-weighted imaging for differentiating between desmoid tumors and malignant soft tissue tumors. J Magn Reson Imaging 33:189–193

    Article  PubMed  Google Scholar 

  • Onikul E, Fletcher BD, Parham DM, Chen G (1996) Accuracy of MR imaging for estimating extent of osteosarcoma. Am J Roentgenol 167:1211–1215

    Article  CAS  Google Scholar 

  • Ortiz EJ, Isler MH, Navia JE, Canosa R (2005) Pathologic fractures in children. Clin Orthop 432:116–126

    Article  Google Scholar 

  • Parrish FF, Murray JA (1970) Surgical treatment for secondary neoplastic fractures. J Bone Joint Surg Am 52A:665–686

    Article  Google Scholar 

  • Peabody TD, Gibbs CP Jr, Simon MA (1998) Evaluation and staging of musculoskeletal neoplasms. J Bone Joint Surg Am 80A:1204–1218

    Article  Google Scholar 

  • Ramanna L, Waxman A, Binney G, Waxman S, Mirra J, Rosen G (1990) Thallium-201 scintigraphy in bone sarcoma: comparison with gallium-67 and technetium-MDP in the evaluation of chemotherapeutic response. J Nucl Med 31:567–572

    CAS  PubMed  Google Scholar 

  • Razek A, Nada N, Ghaniem M, Elkhamary S (2012) Assessment of soft tissue tumours of the extremities with diffusion echoplanar MR imaging. Radiol Med 117:96–101

    Article  CAS  PubMed  Google Scholar 

  • Reddick W, Langston J, Meyer W et al (1994) Discrete signal processing of dynamic contrast-enhanced MR imaging: statistical validation and preliminary clinical application. J Magn Reson Imaging 4:397–404

    Article  CAS  PubMed  Google Scholar 

  • van Rijswijk CSP, Geirnaerdt MJA, Hogendoorn PCW, Peterse JL, van Coevorden F, Taminiau AHM, Tollenaar RAEM, Kroon BBR, Bloem JL (2003) Dynamic contrast-enhanced MR imaging in monitoring response to isolated limb perfusion in high grade soft tissue sarcoma: initial results. Eur Radiol 13:1849–1858

    Article  PubMed  Google Scholar 

  • van Rijswijk CSP, Geirnaerdt MJA, Hogendoorn PCW, Taminiau AHM, van Coevorden F, Zwinderman AH, Pope TL, Bloem JL (2004) Soft-tissue tumors: value of static and dynamic gadopentetate dimeglumine-enhanced MR imaging in prediction of malignancy. Radiology 233:493–502

    Article  PubMed  Google Scholar 

  • Roth SE, Mousavi P, Finkelstein J, Chow E, Kreder H, Whyne CM (2004) Metastatic burst fracture risk prediction using biomechanically based equations. Clin Orthop 419:83–90

    Article  Google Scholar 

  • Saifuddin A, Burnett SJD, Mitchell R (1998) Pictorial review: ultrasonography of primary bone tumours. Clin Radiol 53:239–246

    Article  CAS  PubMed  Google Scholar 

  • Saraph V, Linhart WE (2005) Modern treatment of pathological fractures in children. Injury 36(Suppl 1):A64–A74

    Article  PubMed  Google Scholar 

  • Sauer R, Jürgens H, Burgers JM et al (1987) Prognostic factors in the treatment of Ewing’s sarcoma: the Ewing’s sarcoma study group of the German Society of Paediatric Oncology CESS 81. Radiother Oncol 10:101–110

    Article  CAS  PubMed  Google Scholar 

  • Scherer A, Wittsack HJ, Strupp C et al (2002) Vertebral fractures in multiple myeloma: first results of assessment of fracture risk using dynamic contrast-enhanced MR imaging. Ann Hematol 81:517–521

    Article  CAS  PubMed  Google Scholar 

  • Schulte M, Brecht-Krauss D, Werner M, Hartwig E, Sarkar MR, Keppler P, Kotzerke J, Guhlmann A, Delling G, Reske SN (1999) Evaluation of neoadjuvant therapy response of osteogenic sarcoma using FDG PET. J Nucl Med 40:1637–1643

    CAS  PubMed  Google Scholar 

  • Schwarzbach MH, Hinz U, Dimitrakopoulou-Strauss A, Willeke F, Cardona S, Mechtersheimer G, Lehnert T, Strauss LG, Herfarth C, Büchler MW (2005) Prognostic significance of preoperative [18-F] fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging in patients with resectable soft tissue sarcomas. Ann Surg 241:286–294

    Article  PubMed  PubMed Central  Google Scholar 

  • Shapeero LG, Henry-Amar M, Vanel D (1992) Response of osteosarcoma and Ewing sarcoma to preoperative chemotherapy: assessment with dynamic and static MR imaging and skeletal scintigraphy. Investig Radiol 27:989–991

    Article  CAS  Google Scholar 

  • Shin KH, Moon SH, Suh JS, Yang WI (2000) Tumor volume change as a predictor of chemotherapeutic response in osteosarcoma. Clin Orthop 376:200–208

    Article  Google Scholar 

  • Skeletal Lesions Interobserver Correlation amongst Expert Diagnosticians (SLICED) Study Group (2007) Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones. J Bone Joint Surg Am 89:2113–2123

    Article  Google Scholar 

  • Snell WE, Beals RK (1964) Femoral metastases and fractures from breast cancer. Surg Gynecol Obstet 119:22–24

    CAS  PubMed  Google Scholar 

  • Stacy GS, Mahal RS, Peabody TD (2006) Staging of bone tumors: a review with illustrative examples. Am J Roentgenol 186:967–976

    Article  Google Scholar 

  • Subhawong TK, Durand DJ, Thawait GK, Jacobs MA, Fayad LM (2013) Characterization of soft tissue masses: can quantitative diffusion weighted imaging reliably distinguish cysts from solid masses? Skelet Radiol 42:1583–1592

    Article  Google Scholar 

  • Taneichi H, Kaneda K, Takeda N et al (1997) Risk factors and probability of vertebral body collapse in metastases of the thoracic and lumbar spine. Spine 22:239–245

    Article  CAS  PubMed  Google Scholar 

  • Teo HEL, Peh WCG (2004) The role of imaging in the staging and treatment planning of primary malignant bone tumors in children. Eur Radiol 14:465–475

    Article  PubMed  Google Scholar 

  • Uhl M, Saueressig U, Koehler G, Kontny U, Niemeyer C, Reichardt W, Ilyasof K, Bley T, Langer M (2006) Evaluation of tumour necrosis during chemotherapy with diffusion-weighted MR imaging: preliminary results in osteosarcomas. Pediatr Radiol 36:1306–1311

    Article  PubMed  Google Scholar 

  • van Trommel MF, Kroon HM, Bloem JL, Hogendoorn PC, Taminiau AH (1997) MR imaging based strategies in limb salvage surgery for osteosarcoma of the distal femur. Skelet Radiol 26:636–641

    Article  Google Scholar 

  • Verstraete KL, De Deene Y, Roels H, Dierick A, Uyttendaele D, Kunnen M (1994a) Benign and malignant musculoskeletal lesions: dynamic contrast-enhanced MR imaging—parametric “first-pass” images depict tissue vascularization and perfusion. Radiology 192:835–843

    Article  CAS  PubMed  Google Scholar 

  • Verstraete KL, Dierick A, De Deene Y et al (1994b) First-pass images of musculoskeletal lesions: a new and useful diagnostic application of dynamic contrast-enhanced MR imaging. Magn Reson Imaging 12:687–702

    Article  CAS  PubMed  Google Scholar 

  • Verstraete KL, Vanzieleghem B, De Deene Y et al (1995) Static, dynamic and first-pass imaging of musculoskeletal lesions by use of gadodiamide injection. Acta Radiol 36:27–36

    Article  CAS  PubMed  Google Scholar 

  • Ward WG, Spang J, Howe D, Gordon S (2000) Femoral recon nails for metastatic disease: indications, technique and results. Am J Orthop 29:34–42

    CAS  PubMed  Google Scholar 

  • Whyne CM, Serena S, Lotz JC (2003) Burst fracture in the metastatically involved spine. Spine 28:652–660

    PubMed  Google Scholar 

  • Woertler K, Lindner N, Gosher G, Brinkschmidt C, Heindel W (2000) Osteochondroma: MR imaging of tumor-related complications. Eur Radiol 10:832–840

    Article  CAS  PubMed  Google Scholar 

  • Wang CS, Du LJ, Si MJ, Yin QH, Chen L, Shu M, Yuan F, Fei XC, Ding XY (2013) Noninvasive assessment of response to neoadjuvant chemotherapy in osteosarcoma of long bones with diffusion-weighted imaging: an initial in vivo study. PLoS One 26(8):e72679

    Article  CAS  Google Scholar 

  • Woertler K (2003) Benign bone tumors and tumor-like lesions: value of cross-sectional imaging. Eur Radiol 13:1820–1835

    Article  PubMed  Google Scholar 

  • Van der Woude HJ, Verstraete KL, Hogendoorn PCW, Taminiau AHM, Hermans J, Bloem JL (1998b) Musculoskeletal tumors: does fast dynamic contrast-enhanced subtraction MR imaging contribute to the characterization? Radiology 208:821–828

    Article  PubMed  Google Scholar 

  • Van der Woude HJ, Bloem JL, Hogendoorn PCW (1998a) Postoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing sarcoma: review of current imaging modalities. Skelet Radiol 27:57–71

    Article  Google Scholar 

  • Van der Woude HJ, Bloem JL, Verstraete KL et al (1995) Osteosarcoma and Ewing’s sarcoma after neoadjuvant chemotherapy: value of dynamic MR imaging in detecting viable tumor before surgery. Am J Roentgenol 165:593–598

    Article  Google Scholar 

  • DeWald RL, Bridwell KH, Prodromas C et al (1985) Reconstructive spinal surgery as palliation for metastatic malignancies of the spine. Spine 10:21–26

    Article  CAS  PubMed  Google Scholar 

  • Wunder JS, Healey JH, Davis AM, Brennan MF (2000) A comparison of staging systems for localized extremity soft tissue sarcoma. Cancer 88:2721–2730

    Article  CAS  PubMed  Google Scholar 

  • Yakushiji T, Oka K, Sato H, Yorimitsu S, Fujimoto T, Yamashita Y, Mizuta H (2009) Characterization of chondroblastic osteosarcoma: gadolinium-enhanced versus diffusion-weighted MR imaging. J Magn Reson Imaging 29:895–900

    Article  PubMed  Google Scholar 

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Douis, H., Davies, A.M. (2020). Bone and Soft Tissue Tumours. In: Cassar-Pullicino, V., Davies, A. (eds) Measurements in Musculoskeletal Radiology. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68897-6_21

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