Abstract
Respiratory motion represents a major problem in radiation therapy of thoracic tumors. Methods for compensation require comprehensive knowledge of underlying dynamics. In this study, motion of thoracic anatomical and pathological structures in lung cancer patients was analyzed using motion artifact reduced 4D CT data sets of high temporal and spatial resolution. Motion artifact reduction was achieved by applying an optical flow based 4D CT reconstruction method. Motion analysis especially focuses on inner organ and tumor mobility and the interrelation between tumor / inner organ motion and chest wall motion. Trajectories of tumor mass centers and organ specific landmarks were determined and analyzed. To study chest wall motion a non-linear registration based point tracking scheme was applied to compute trajectories of points on the chest wall skin. The interrelation of chest wall and tumor / inner organ motion was investigated using methods of multivariate statistics. Results show that, for instance, tumor motion patterns differ noticeably between the patients; a dependency between tumor motion and tumor location seems apparent. The correlation of tumor motion and motion of chest wall points depends on the patient breathing pattern (e.g. abdominal or chest wall breathing). Thus, skin regions which are suitable for prediction of tumor motion differ between the patients.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
International Commission on Radiation Units and Measurements (ICRU), Prescribing, recording, and reporting photon beam therapy (supplement to ICRU report 50), Bethesda, Md., 1998.
D.A. Low et al., Medical Physics 30, 1254, 2003.
J. Ehrhardt et al., Medical Physics, 2007 (accepted).
W. Lu et al., Medical Physics 32, 890, 2005.
J.P. Thirion, Medical Image Analysis 2, 243, 1998.
B. Horn and B. Schunck, Artif Intell 17, 185, 1981.
K. Langen and D. Jones, Int J Radiat Oncol Biol Phys 50, 265, 2001.
N. Koch et al., Int J Radiat Oncol Biol Phys 60, 1459, 2004.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Werner, R., Ehrhardt, J., Frenzel, T., Lu, W., Low, D., Handels, H. (2007). Analysis of Tumor-Influenced Respiratory Dynamics Using Motion Artifact Reduced Thoracic 4D CT Images. In: Buzug, T.M., Holz, D., Bongartz, J., Kohl-Bareis, M., Hartmann, U., Weber, S. (eds) Advances in Medical Engineering. Springer Proceedings in Physics, vol 114. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68764-1_30
Download citation
DOI: https://doi.org/10.1007/978-3-540-68764-1_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-68763-4
Online ISBN: 978-3-540-68764-1
eBook Packages: EngineeringEngineering (R0)