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Biology and Pathology of Pediatric Non-Hodgkin Lymphoma

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Pediatric Lymphomas

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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References

  1. (1982) The Non-Hodgkin’s Lymphoma Pathologic Classification Project. The National Cancer Institute sponsored study of classification of non-Hodgkin’s lymphomas: summary and description of Working Formulation for clinical usage. Cancer 49:2112–2135

    Google Scholar 

  2. (1997) Effect of age on the characteristics and clinical behavior of non-Hodgkin’s lymphoma patients. The Non-Hodgkin’s Lymphoma Classification Project. Ann Oncol 8:973–978

    Google Scholar 

  3. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues. Washington, D.C.: IARC Press, 2001

    Google Scholar 

  4. Abruzzo L, Jaffe E, et al. (1992) T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy. Am J Surg Pathol 16:236–245

    PubMed  CAS  Google Scholar 

  5. Adams JM, Gerondakis S, et al. (1983) Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas. Proc Natl Acad Sci U S A 80:1982–1986

    Article  PubMed  CAS  Google Scholar 

  6. Adams JM, Harris AW, et al. (1985) The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318:533–538

    Article  PubMed  CAS  Google Scholar 

  7. Alessandri AJ, Pritchard SL, et al. (2002) A population-based study of pediatric anaplastic large cell lymphoma. Cancer 94:1830–1835

    Article  PubMed  Google Scholar 

  8. Alizadeh AA, Eisen MB, et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403:503–511

    Article  PubMed  CAS  Google Scholar 

  9. Alland L, Muhle R, et al. (1997) Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387:49–55

    Article  PubMed  CAS  Google Scholar 

  10. Allman D, Jain A, et al. (1996) BCL-6 expression during B-cell activation. Blood 87:5257–5268

    PubMed  CAS  Google Scholar 

  11. Amati B, Brooks MW, et al. (1993) Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72:233–245

    Article  PubMed  CAS  Google Scholar 

  12. Andersen MK, Christiansen DH, et al. (2001) Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992. Br J Haematol 114:539–543

    Article  PubMed  CAS  Google Scholar 

  13. Aplan PD, Jones CA, et al. (1997) An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. Embo J 16:2408–2419

    Article  PubMed  CAS  Google Scholar 

  14. Arber DA (2001) Realistic pathologic classification of acute myeloid leukemias. Am J Clin Pathol 115:552–560

    Article  PubMed  CAS  Google Scholar 

  15. Armes J, Southey M, et al. (1996) Molecular analysis in the diagnosis of pediatric lymphomas. Pediatr Pathol Lab Med 16:435–449

    PubMed  CAS  Google Scholar 

  16. Artavanis-Tsakonas S, Matsuno K, et al. (1995) Notch signaling. Science 268:225–232

    Article  PubMed  CAS  Google Scholar 

  17. Artavanis-Tsakonas S, Rand MD, et al. (1999) Notch signaling: cell fate control and signal integration in development. Science 284:770–776

    Article  PubMed  CAS  Google Scholar 

  18. Askew DS, Ashmun RA, et al. (1991) Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6:1915–1922

    PubMed  CAS  Google Scholar 

  19. Aster J, Pear W, et al. (1994) Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harb Symp Quant Biol 59:125–136

    PubMed  CAS  Google Scholar 

  20. Ayer DE, Eisenman RN (1993) A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev 7:2110–2119

    PubMed  CAS  Google Scholar 

  21. Ayer DE, Kretzner L, et al. (1993) Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72:211–222

    Article  PubMed  CAS  Google Scholar 

  22. Ayer DE, Lawrence QA, et al. (1995) Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80:767–776

    Article  PubMed  CAS  Google Scholar 

  23. Baer R, Hwang LY, et al. (1997) Transcription factors of the bHLH and LIM families: synergistic mediators of T cell acute leukemia? Curr Top Microbiol Immunol 220:55–65

    PubMed  CAS  Google Scholar 

  24. Bain G, Engel I, et al. (1997) E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol 17:4782–4791

    PubMed  CAS  Google Scholar 

  25. Ballerini P, Blaise A, et al. (2002) HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis. Blood 100:991–997

    Article  PubMed  CAS  Google Scholar 

  26. Baron BW, Stanger RR, et al. (1995) BCL6 encodes a sequence-specific DNA-binding protein. Genes Chromosomes Cancer 13:221–224

    PubMed  CAS  Google Scholar 

  27. Bartram CR (1992) Molecular genetic aspects of myelodysplastic syndromes. Hematol/Oncol Clin N Amer 6:557–570

    CAS  Google Scholar 

  28. Bash RO, Hall S, et al. (1995) Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study. Blood 86:666–676

    PubMed  CAS  Google Scholar 

  29. Bastard C, Deweindt C, et al. (1994) LAZ3 rearrangements in non-Hodgkin’s lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 83:2423–2427

    PubMed  CAS  Google Scholar 

  30. Bastard C, Tilly H, et al. (1992) Translocations involving band 3q27 and Ig gene regions in non-Hodgkin’s lymphoma. Blood 79:2527–2531

    PubMed  CAS  Google Scholar 

  31. Begley CG, Aplan PD, et al. (1989) Chromosomal translocation in a human leukemic stem cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci U S A 86:2031–2035

    Article  PubMed  CAS  Google Scholar 

  32. Beljaards RC, Kaudewitz P, et al. (1993) Primary cutaneous CD30-positive large cell lymphoma: definition of a new type of cutaneous lymphoma with a favorable prognosis. A European Multicenter Study of 47 patients. Cancer 71:2097–2104

    Article  PubMed  CAS  Google Scholar 

  33. Benharroch D, Meguerian-Bedoyan Z, et al. (1998) ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91:2076–2084

    PubMed  CAS  Google Scholar 

  34. Bennett J, Catovsky D, et al. (1976) Proposals for the classification of acute leukemias. French-American-British (FAB) Cooperative Group. Br J Hematol 33:451–458

    CAS  Google Scholar 

  35. Berard CW (1985) Morphological definition of Burkitt’s tumour: historical review and present status. IARC Sci Publ 31–35

    Google Scholar 

  36. Bernard O, Lecointe N, et al. (1991) Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5′ part of the tal-1 gene. Oncogene 6:1477–1488

    PubMed  CAS  Google Scholar 

  37. Bernard OA, Busson-LeConiat M, et al. (2001) A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. Leukemia 15:1495–1504

    Article  PubMed  CAS  Google Scholar 

  38. Bischof D, Pulford K, et al. (1997) Role of the nucleophosmin (NPM) portion of the non-Hodgkin’s lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis. Mol Cell Biol 17:2312–2325

    PubMed  CAS  Google Scholar 

  39. Blackwood EM, Eisenman RN (1991) Max: a helixloop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251:1211–1217

    Article  PubMed  CAS  Google Scholar 

  40. Bleesing JJ, Fleisher TA (2001) Immunophenotyping. Semin Hematol 38:100–110

    Article  PubMed  CAS  Google Scholar 

  41. Boehm T, Foroni L, et al. (1991) The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A 88:4367–4371

    Article  PubMed  CAS  Google Scholar 

  42. Bollum F (1979) Terminal deoxytidyl transferase as a hematopoietic marker. Blood 54:1203–1215

    PubMed  CAS  Google Scholar 

  43. Borer RA, Lehner CF, et al. (1989) Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56:379–390

    Article  PubMed  CAS  Google Scholar 

  44. Borrow J, Shipley J, et al. (1994) Molecular analysis of simple variant translocations in acute promyelocytic leukemia. Genes Chromosomes Cancer 9:234–243

    PubMed  CAS  Google Scholar 

  45. Bray RA (2001) Flow cytometry in human leukocyte antigen testing. Semin Hematol 38:194–200

    Article  PubMed  CAS  Google Scholar 

  46. Brown L, Cheng JT, et al. (1990) Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. Embo J 9:3343–3351

    PubMed  CAS  Google Scholar 

  47. Brugieres L, LeDeley MC, et al. (1998) CD30+ anaplastic large cell lymphoma in children: analysis of 82 patients enrolled in two consecutive studies of the French Society of Pediatric Oncology. Blood 92:3591–3598

    PubMed  CAS  Google Scholar 

  48. Brunning RD, Borowitz M, et al. (2001) Precursor T lymphoblastic leukaemia/lymphoma, p. 115–117. Lyon: IARC Press

    Google Scholar 

  49. Bucher K, Sofroniew MV, et al. (2000) The T cell oncogene Tal2 is necessary for normal development of the mouse brain. Dev Biol 227:533–544

    Article  PubMed  CAS  Google Scholar 

  50. Bullrich F, Morris SW, et al. (1994) Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas. Cancer Res 54:2873–2877

    PubMed  CAS  Google Scholar 

  51. Burkitt D (1958) A sarcoma involving the jaws in African children. Br J Surg 46:218–223

    PubMed  CAS  Google Scholar 

  52. Burnett RC, David JC, et al. (1991) The LCK gene is involved in the t(1;7)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2. Genes Chromosomes Cancer 3:461–467

    PubMed  CAS  Google Scholar 

  53. Cairo MS (2002) Current advances and future strategies of B large cell lymphoma in children and adolescents. Proc Am Soc Oncol 21:512–519

    Google Scholar 

  54. Cairo MS, Raetz E, et al. Non-Hodgkin’s lymphoma in children, 6th edition, p. 2337–2348. London: BC Decker Inc, 2003

    Google Scholar 

  55. Cairo MS, Sposto R, et al. (2003) Childhood and adolescent large-cell lymphoma (LCL): a review of the Children’s Cancer Group experience. Am J Hematol 72:53–63

    Article  PubMed  Google Scholar 

  56. Cairo MS, Sposto R, et al. (2003) Burkitt’s and Burkitt-like lymphoma in children and adolescents: a review of the Children’s Cancer Group experience. Br J Haematol 120:660–670

    Article  PubMed  Google Scholar 

  57. Campo E (2003) Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt’s lymphoma. Hum Pathol 34:330–335

    Article  PubMed  CAS  Google Scholar 

  58. Cattoretti G, Chang CC, et al. (1995) BCL-6 protein is expressed in germinal-center B cells. Blood 86:45–53

    PubMed  CAS  Google Scholar 

  59. Chadburn A, Frizzera G (1999) Mediastinal large B-cell lymphoma versus classic Hodgkin lymphoma. Am J Clin Pathol 112:155–158

    PubMed  CAS  Google Scholar 

  60. Chan KW, Kaikov Y, et al. (1989) Thrombocytosis in childhood: a survey of 94 patients. Pediatrics 84:1064–1067

    PubMed  CAS  Google Scholar 

  61. Chan WC, Huang JZ (2001) Gene expression analysis in aggressive NHL. Ann Hematol 80Suppl 3:B38–41

    PubMed  CAS  Google Scholar 

  62. Chang CC, Ye BH, et al. (1996) BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci U S A 93:6947–6952

    Article  PubMed  CAS  Google Scholar 

  63. Chen J, Deangelo DJ, et al. (2004) PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci U S A 101:14479–14484

    Article  PubMed  CAS  Google Scholar 

  64. Chen Q, Cheng JT, et al. (1990) The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. Embo J 9:415–424

    PubMed  CAS  Google Scholar 

  65. Chervinsky DS, Zhao XF, et al. (1999) Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol Cell Biol 19:5025–5035

    PubMed  CAS  Google Scholar 

  66. Chiarle R, Gong JZ, et al. (2003) NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood 101:1919–1927

    Article  PubMed  CAS  Google Scholar 

  67. Chu PG, Chang KL, et al. (1999) Practical applications of immunohistochemistry in hematolymphoid neoplasms. Ann Diagn Pathol 3:104–133

    Article  PubMed  CAS  Google Scholar 

  68. Cohen-Kaminsky S, Maouche-Chretien L, et al. (1998) Chromatin immunoselection defines a TAL-1 target gene. Embo J 17:5151–5160

    Article  PubMed  CAS  Google Scholar 

  69. Colombo E, Marine JC, et al. (2002) Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol 4:529–533

    Article  PubMed  CAS  Google Scholar 

  70. Condorelli GL, Facchiano F, et al. (1996) T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice. Cancer Res 56:5113–5119

    PubMed  CAS  Google Scholar 

  71. Cook JR, Dehner LP, et al. (2001) Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol 25:1364–1371

    Article  PubMed  CAS  Google Scholar 

  72. Cossman J, Chused T, et al. (1983) Diversity of immunological phenotypes of lymphoblastic lymphoma. Cancer Res 43:4486–4490

    PubMed  CAS  Google Scholar 

  73. Cotelingam JD (2003) Bone marrow biopsy: interpretive guidelines for the surgical pathologist. Adv Anat Pathol 10:8–26

    PubMed  Google Scholar 

  74. Cotelingham J, Witesby F, et al. (1985) Malignant lymphoma in patients with the Wiscott-Aldrich syndrome. Canc Invest 3:515-

    Google Scholar 

  75. Croce CM, Thierfelder W, et al. (1983) Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt. Proc Natl Acad Sci U S A 80:6922–6926

    Article  PubMed  CAS  Google Scholar 

  76. Dalla-Favera R, Bregni M, et al. (1982) Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A 79:7824–7827

    Article  PubMed  CAS  Google Scholar 

  77. Dalla-Favera R, Ye BH, et al. (1996) BCL-6 in diffuse large-cell lymphomas. Important Adv Oncol 139–148

    Google Scholar 

  78. Dallery E, Galiegue-Zouitina S, et al. (1995) TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation. Oncogene 10:2171–2178

    PubMed  CAS  Google Scholar 

  79. Dang CV (1999) c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol 19:1–11

    PubMed  CAS  Google Scholar 

  80. Dang CV, Resar LM, et al. (1999) Function of the c-Myc oncogenic transcription factor. Exp Cell Res 253:63–77

    Article  PubMed  CAS  Google Scholar 

  81. Das I, Craig C, et al. (2004) Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function. J Biol Chem 279:30771–30780

    Article  PubMed  CAS  Google Scholar 

  82. Davenport J, Neale GA, et al. (2000) Identification of genes potentially involved in LMO2-induced leukemogenesis. Leukemia 14:1986–1996

    Article  PubMed  CAS  Google Scholar 

  83. Davis RE, Brown KD, et al. (2001) Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 194:1861–1874

    Article  PubMed  CAS  Google Scholar 

  84. Davison JM, Morgan TW, et al. (1998) Subtracted, unique-sequence, in situ hybridization: experimental and diagnostic applications. Am J Pathol 153:1401–1409

    PubMed  CAS  Google Scholar 

  85. de Ruijter AJ, van Gennip AH, et al. (2003) Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J 370:737–749

    Article  PubMed  Google Scholar 

  86. de Wolf-Peeters C (1991) Bone marrow trephine interpretation: diagnostic utility and potential pitfalls. Histopathology 18:489–493

    PubMed  Google Scholar 

  87. Dear TN, Sanchez-Garcia I, et al. (1993) The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc Natl Acad Sci U S A 90:4431–4435

    Article  PubMed  CAS  Google Scholar 

  88. Deininger MW, O’Brien SG, et al. (2003) Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol 21:1637–1647

    Article  PubMed  CAS  Google Scholar 

  89. Demierre MF, Goldberg LJ, et al. (1997) Is it lymphoma or lymphomatoid papulosis? J Am Acad Dermatol 36:765–772

    Article  PubMed  CAS  Google Scholar 

  90. Diebold J, Jaffe ES, et al. (2001) Burkitt lymphoma, p. 181–184. Lyon: IARC Press

    Google Scholar 

  91. Doll DC, Ringenberg QS, et al. (1989) Bone marrow biopsy in the initial staging of Hodgkin’s disease. Med Pediatr Oncol 17:1–5

    PubMed  CAS  Google Scholar 

  92. Dolon J, Jaffe E, et al. (1977) Terminal deoxytidyl transferase activity in malignant lymphomas. N Engl J Med 297:461–466

    Article  Google Scholar 

  93. Downing JR, Shurtleff SA, et al. (1995) Molecular detection of the (2;5) translocation of non-Hodgkin’s lymphoma by reverse transcriptase-polymerase chain reaction. Blood 85:3416–3422

    PubMed  CAS  Google Scholar 

  94. Drexler HG, Gignac SM, et al. (2000) Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas. Leukemia 14:1533–1559

    Article  PubMed  CAS  Google Scholar 

  95. Dube ID, Kamel-Reid S, et al. (1991) A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14). Blood 78:2996–3003

    PubMed  CAS  Google Scholar 

  96. Dube ID, Raimondi SC, et al. (1986) A new translocation, t(10;14)(q24;q11), in T cell neoplasia. Blood 67:1181–1184

    PubMed  CAS  Google Scholar 

  97. Duyster J, Bai RY, et al. (2001) Translocations involving anaplastic lymphoma kinase (ALK). Oncogene 20:5623–5637

    Article  PubMed  CAS  Google Scholar 

  98. Dyer MJ (2003) The pathogenetic role of oncogenes deregulated by chromosomal translocation in B-cell malignancies. Int J Hematol 77:315–320

    PubMed  CAS  Google Scholar 

  99. Eagar TN, Tang Q, et al. (2004) Notch 1 signaling regulates peripheral T cell activation. Immunity 20:407–415

    Article  PubMed  CAS  Google Scholar 

  100. Eilers M, Schirm S, et al. (1991) The MYC protein activates transcription of the alpha-prothymosin gene. Embo J 10:133–141

    PubMed  CAS  Google Scholar 

  101. Ellisen LW, Bird J, et al. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649–661

    Article  PubMed  CAS  Google Scholar 

  102. Elmberger PG, Lozano MD, et al. (1995) Transcripts of the npm-alk fusion gene in anaplastic large cell lymphoma, Hodgkin’s disease, and reactive lymphoid lesions. Blood 86:3517–3521

    PubMed  CAS  Google Scholar 

  103. Ema M, Faloon P, et al. (2003) Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev 17:380–393

    Article  PubMed  CAS  Google Scholar 

  104. Emanuel BS, Selden JR, et al. (1984) The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts the V kappa locus. Proc Natl Acad Sci U S A 81:2444–2446

    Article  PubMed  CAS  Google Scholar 

  105. Endoh M, Ogawa M, et al. (2002) SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. Embo J 21:6700–6708

    Article  PubMed  CAS  Google Scholar 

  106. Erikson J, Nishikura K, et al. (1983) Translocation of an immunoglobulin kappa locus to a region 3’ of an unrearranged c-myc oncogene enhances c-myc transcription. Proc Natl Acad Sci U S A 80:7581–7585

    Article  PubMed  CAS  Google Scholar 

  107. Evan GI, Wyllie AH, et al. (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69:119–128

    Article  PubMed  CAS  Google Scholar 

  108. Ezdinli EZ, Costello W, et al. (1979) Eastern Cooperative Oncology Group experience with the rappaport classification of non-Hodgkin’s lymphomas. Cancer 43:544–550

    Article  PubMed  CAS  Google Scholar 

  109. Falini B (2001) Anaplastic large cell lymphoma: pathological, molecular and clinical features. Br J Haematol 114:741–760

    Article  PubMed  CAS  Google Scholar 

  110. Falini B, Bigerna B, et al. (1996) Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin’s disease. Blood 87:465–471

    PubMed  CAS  Google Scholar 

  111. Falini B, Mason DY (2002) Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry. Blood 99:409–426

    Article  PubMed  CAS  Google Scholar 

  112. Fan YS (2002) Molecular cytogenetics in medicine. An overview. Methods Mol Biol 204:3–20

    PubMed  CAS  Google Scholar 

  113. Felsher DW (2003) Cancer revoked: oncogenes as therapeutic targets. Nat Rev Cancer 3:375–380

    Article  PubMed  CAS  Google Scholar 

  114. Felsher DW, Bishop JM (1999) Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 4:199–207

    Article  PubMed  CAS  Google Scholar 

  115. Ferrando AA, Neuberg DS, et al. (2002) Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1:75–87

    Article  PubMed  CAS  Google Scholar 

  116. Ferrier R, Nougarede R, et al. (1999) Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105. Oncogene 18:995–1005

    Article  PubMed  CAS  Google Scholar 

  117. Feuerstein N, Mond JJ, et al. (1990) Evidence for DNA binding activity of numatrin (B23), a cell cycle-regulated nuclear matrix protein. Biochim Biophys Acta 1087:127–136

    PubMed  CAS  Google Scholar 

  118. Finger LR, Kagan J, et al. (1989) Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A 86:5039–5043

    Article  PubMed  CAS  Google Scholar 

  119. Flenghi L, Bigerna B, et al. (1996) Monoclonal antibodies PG-B6a and PG-B6p recognize, respectively, a highly conserved and a formol-resistant epitope on the human BCL-6 protein amino-terminal region. Am J Pathol 148:1543–1555

    PubMed  CAS  Google Scholar 

  120. Flenghi L, Ye BH, et al. (1995) A specific monoclonal antibody (PG-B6) detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol 147:405–411

    PubMed  CAS  Google Scholar 

  121. Foley KP, Eisenman RN (1999) Two MAD tails: what the recent knockouts of Mad1 and Mxi1 tell us about the MYC/MAX/MAD network. Biochim Biophys Acta 1423:M37–47

    PubMed  CAS  Google Scholar 

  122. Frost M, Newell JO, et al. (2004) Comparative immunohistochemical analysis of pediatric Burkitt lymphoma and diffuse large B-cell lymphoma. Am J Clin Pathol 121:384–392

    Article  PubMed  Google Scholar 

  123. Fujimoto J, Shiota M, et al. (1996) Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5). Proc Natl Acad Sci U S A 93:4181–4186

    Article  PubMed  CAS  Google Scholar 

  124. Galiegue-Zouitina S, Quief S, et al. (1995) Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation. C R Acad Sci III 318:1125–1131

    PubMed  CAS  Google Scholar 

  125. Garcia JL, Hernandez JM, et al. (2003) Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt’s lymphoma. A cytogenetic and comparative genomic hybridization study. Leukemia 17:2016–2024

    Article  PubMed  CAS  Google Scholar 

  126. Gartel AL, Shchors K (2003) Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes. Exp Cell Res 283:17–21

    Article  PubMed  CAS  Google Scholar 

  127. Gascoyne RD, Lamant L, et al. (2003) ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. Blood 102:2568–2573

    Article  PubMed  CAS  Google Scholar 

  128. Glassman AB (2000) Chromosomal abnormalities in acute leukemias. Clin Lab Med 20:39–48

    PubMed  CAS  Google Scholar 

  129. Goldsby RE, Carroll WL (1998) The molecular biology of pediatric lymphomas. J Pediatr Hematol Oncol 20:282–296

    Article  PubMed  CAS  Google Scholar 

  130. Golub TR (2001) Genomic approaches to the pathogenesis of hematologic malignancy. Curr Opin Hematol 8:252–261

    Article  PubMed  CAS  Google Scholar 

  131. Gottgens B, Nastos A, et al. (2002) Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. Embo J 21:3039–3050

    Article  PubMed  CAS  Google Scholar 

  132. Gown AM (2004) Unmasking the mysteries of antigen or epitope retrieval and formalin fixation. Am J Clin Pathol 121:172–174

    Article  PubMed  Google Scholar 

  133. Grandori C, Mac J, et al. (1996) Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. Embo J 15:4344–4357

    PubMed  CAS  Google Scholar 

  134. Grant PA, Duggan L, et al. (1997) Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11:1640–1650

    PubMed  CAS  Google Scholar 

  135. Green AR, Lints T, et al. (1992) SCL is coexpressed with GATA-1 in hemopoietic cells but is also expressed in developing brain. Oncogene 7:653–660

    PubMed  CAS  Google Scholar 

  136. Greer C, Peterson S, et al. (1991) PCR amplification from paraffin-embedded tissues. Effects of fixative and fixation time. Am J Clin Pathol 95:117–124

    PubMed  CAS  Google Scholar 

  137. Griffith R, Kelly D, et al. (1987) A morphologic study of childhood lymphoma of lymphoblastic type. The Pediatric Oncology Group experience. Cancer 59:1126–1131

    Article  PubMed  CAS  Google Scholar 

  138. Grutz GG, Bucher K, et al. (1998) The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. Embo J 17:4594–4605

    Article  PubMed  CAS  Google Scholar 

  139. Hacein-Bey-Abina S, von Kalle C, et al. (2003) A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348:255–256

    Article  PubMed  Google Scholar 

  140. Hall GW (2002) Cytogenetic and molecular genetic aspects of childhood myeloproliferative/myelodysplastic disorders. Acta Haematol 108:171–179

    Article  PubMed  Google Scholar 

  141. Hallman J, Geisinger K (1994) Cytology of fluids from pleural, peritoneal and pericardial cavities in children. A comprehensive review. Acta Cytol 38:209–217

    PubMed  CAS  Google Scholar 

  142. Hansen-Hagge TE, Schafer M, et al. (2002) Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11). Leukemia 16:2205–2212

    Article  PubMed  CAS  Google Scholar 

  143. Harper SE, Qiu Y, et al. (1996) Sin3 corepressor function in Myc-induced transcription and transformation. Proc Natl Acad Sci U S A 93:8536–8540

    Article  PubMed  CAS  Google Scholar 

  144. Harris NL, Jaffe ES, et al. (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84:1361–1392

    PubMed  CAS  Google Scholar 

  145. Harris NL, Stein H, et al. (2001) New approaches to lymphoma diagnosis. Hematology (Am Soc Hematol Educ Program) 194–220

    Google Scholar 

  146. Harrison CJ (2000) The genetics of childhood acute lymphoblastic leukaemia. Baillieres Best Pract Res Clin Haematol 13:427–439

    PubMed  CAS  Google Scholar 

  147. Hasserjian RP, Aster JC, et al. (1996) Modulated expression of notch1 during thymocyte development. Blood 88:970–976

    PubMed  CAS  Google Scholar 

  148. Hatakeyama M, Kono T, et al. (1991) Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association. Science 252:1523–1528

    Article  PubMed  CAS  Google Scholar 

  149. Hatano M (1992) Cell cycle progression, cell death and T cell lymphoma in HOX11 transgenic mice. In: C. W. Roberts (ed.), vol. 80, pp. (suppl) 355a

    Google Scholar 

  150. Hatano M, Roberts CW, et al. (1991) Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science 253:79–82

    Article  PubMed  CAS  Google Scholar 

  151. Hayashi Y (2000) The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia. Semin Hematol 37:368–380

    Article  PubMed  CAS  Google Scholar 

  152. Head DR, Behm FG (1995) Acute lymphoblastic leukemia and the lymphoblastic lymphomas of childhood. Semin Diagn Pathol 12:325–334

    PubMed  CAS  Google Scholar 

  153. Hecht JL, Aster JC (2000) Molecular biology of Burkitt’s lymphoma. J Clin Oncol 18:3707–3721

    PubMed  CAS  Google Scholar 

  154. Heerema N, Poirel, H., Swansbury, J., Sanger, W., Bernheim, A., Talley, P., Patte, C., Gerrard, M., Perkins, S., Raphael, M., McCarthy, K., Sposto, R., Weston, C., and Cairo, M.S. (2003) Chromosomal abnormalities of pediatric (ped) and adult diffuse large B-cell lymphoma (DLBCL) differ and may reflect potential differences in oncogenesis. An international pediatric mature B-cell non-Hodgkin lymphoma study (FAB/LMB96). Blood 102:3139

    Google Scholar 

  155. Heerema NA, Sather HN, et al. (1998) Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children’s Cancer Group. J Clin Oncol 16:1270–1278

    PubMed  CAS  Google Scholar 

  156. Heikkila R, Schwab G, et al. (1987) A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1. Nature 328:445–449

    Article  PubMed  CAS  Google Scholar 

  157. Heinzel T, Lavinsky RM, et al. (1997) A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature 387:43–48

    Article  PubMed  CAS  Google Scholar 

  158. Herblot S, Steff AM, et al. (2000) SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol 1:138–144

    Article  PubMed  CAS  Google Scholar 

  159. Herbst H, Anagnostopoulos J, et al. (1995) ALK gene products in anaplastic large cell lymphomas and Hodgkin’s disease. Blood 86:1694–1700

    PubMed  CAS  Google Scholar 

  160. Higgin JP, Warnke RA (1999) CD30 expression is common in mediastinal large B-cell lymphoma. Am J Clin Pathol 112:241–247

    Google Scholar 

  161. Hojo H, Sasaki Y, et al. (2001) Absence of somatic hypermutation of immunoglobulin heavy chain variable region genes in precursor B-lymphoblastic lymphoma: a study of four cases in childhood and adolescence. Am J Clin Pathol 116:673–682

    Article  PubMed  CAS  Google Scholar 

  162. Hollis GF, Mitchell KF, et al. (1984) A variant translocation places the lambda immunoglobulin genes 3′ to the c-myc oncogene in Burkitt’s lymphoma. Nature 307:752–755

    Article  PubMed  CAS  Google Scholar 

  163. Howell L, Russell L, et al. (1992) The cytology of pediatric masses: a differential diagnosis approach. Diagn Cytopathol 8:107–115

    PubMed  CAS  Google Scholar 

  164. Hsu HL, Cheng JT, et al. (1991) Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol Cell Biol 11:3037–3042

    PubMed  CAS  Google Scholar 

  165. Hsu HL, Huang L, et al. (1994) Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins. Mol Cell Biol 14:1256–1265

    PubMed  CAS  Google Scholar 

  166. Hsu HL, Wadman I, et al. (1994) Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. Proc Natl Acad Sci U S A 91:3181–3185

    Article  PubMed  CAS  Google Scholar 

  167. Huang JZ, Sanger WG, et al. (2002) The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile. Blood 99:2285–2290

    Article  PubMed  CAS  Google Scholar 

  168. Hurlin PJ, Queva C, et al. (1997) Mnt: a novel Max-interacting protein and Myc antagonist. Curr Top Microbiol Immunol 224:115–121

    PubMed  CAS  Google Scholar 

  169. Hutchison RE, Finch C, et al. (2000) Burkitt lymphoma is immunophenotypically different from Burkitt-like lymphoma in young persons. Ann Oncol 11Suppl 1:35–38

    Article  PubMed  Google Scholar 

  170. Hwang LY, Siegelman M, et al. (1993) Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. Oncogene 8:3043–3046

    PubMed  CAS  Google Scholar 

  171. Inhorn R, Aster J, et al. (1995) A syndrome of lymphblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity. Blood 85:1881–1887

    PubMed  CAS  Google Scholar 

  172. Iverson O, Iverson U, et al. (1974) Cell kinetics in Burkitt’s lymphoma. Eur J Cancer 10:1507–1512

    Google Scholar 

  173. Iwahara T, Fujimoto J, et al. (1997) Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene 14:439–449

    Article  PubMed  CAS  Google Scholar 

  174. Iwatsubo T (2004) The gamma-secretase complex: machinery for intramembrane proteolysis. Curr Opin Neurobiol 14:379–383

    Article  PubMed  CAS  Google Scholar 

  175. Jaffe ES HN, Stein H, Vardiman JW (2001) Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tissues. Washington, D.C.: IARC Press

    Google Scholar 

  176. Jain M, Arvanitis C, et al. (2002) Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 297:102–104

    Article  PubMed  CAS  Google Scholar 

  177. Jarriault S, Brou C, et al. (1995) Signalling downstream of activated mammalian Notch. Nature 377:355–358

    Article  PubMed  CAS  Google Scholar 

  178. Johnston JM, Yu MT, et al. (1991) c-myc hypermutation is ongoing in endemic, but not all Burkitt’s lymphoma. Blood 78:2419–2425

    PubMed  CAS  Google Scholar 

  179. Jones SE, Butler JJ, et al. (1977) Histopathologic review of lymphoma cases from the Southwest Oncology Group. Cancer 39:1071–1076

    Article  PubMed  CAS  Google Scholar 

  180. Kadin M (1997) Anaplastic large cell lymphoma and its morphologic variants. Cancer Surv 30:77–86

    PubMed  CAS  Google Scholar 

  181. Kadin ME, Carpenter C (2003) Systemic and primary cutaneous anaplastic large cell lymphomas. Semin Hematol 40:244–256

    Article  PubMed  CAS  Google Scholar 

  182. Kallianpur AR, Jordan JE, et al. (1994) The SCL/TAL-1 gene is expressed in progenitors of both the hematopoietic and vascular systems during embryogenesis. Blood 83:1200–1208

    PubMed  CAS  Google Scholar 

  183. Kappel A, Schlaeger TM, et al. (2000) Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development. Blood 96:3078–3085

    PubMed  CAS  Google Scholar 

  184. Kappen C, Schughart K, et al. (1993) Early evolutionary origin of major homeodomain sequence classes. Genomics 18:54–70

    Article  PubMed  CAS  Google Scholar 

  185. Kaudewitz P, Stein H, et al. (1989) Primary and secondary cutaneous Ki-1+ (CD30+) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical-characteristics. Am J Pathol 135:359–367

    PubMed  CAS  Google Scholar 

  186. Kawamata N, Miki T, et al. (1994) Recognition DNA sequence of a novel putative transcription factor, BCL6. Biochem Biophys Res Commun 204:366–374

    Article  PubMed  CAS  Google Scholar 

  187. Kebriaei P, Anastasi J, et al. (2002) Acute lymphoblastic leukaemia: diagnosis and classification. Best Pract Res Clin Haematol 15:597–621

    Article  PubMed  CAS  Google Scholar 

  188. Kees UR, Lukeis R, et al. (1989) Establishment and characterization of a childhood T-cell acute lymphoblastic leukemia cell line, PER-255, with chromosome abnormalities involving 7q32-34 in association with T-cell receptor-beta gene rearrangement. Blood 74:369–373

    PubMed  CAS  Google Scholar 

  189. Kelliher MA, Seldin DC, et al. (1996) Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. Embo J 15:5160–5166

    PubMed  CAS  Google Scholar 

  190. Kelly D, Nathwani B, et al. (1987) A morphologic study of childhood lymphoma of the undifferentiated type. The Pediatric Oncology Group experience. Cancer 59:1132–1137

    Article  PubMed  CAS  Google Scholar 

  191. Kennedy MA, Gonzalez-Sarmiento R, et al. (1991) HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A 88:8900–8904

    Article  PubMed  CAS  Google Scholar 

  192. Kinney M, Collins R, et al. (1993) A small-cell-predominant variant of primary Ki-1 (CD30)+ T-cell lymphoma. Am J Surg Pathol 17:859–868

    Article  PubMed  CAS  Google Scholar 

  193. Kinney MC, Kadin ME (1999) The pathologic and clinical spectrum of anaplastic large cell lymphoma and correlation with ALK gene dysregulation. Am J Clin Pathol 111:S56–67

    PubMed  CAS  Google Scholar 

  194. Knowles DM, Chamulak GA, et al. (1988) Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS). The New York University Medical Center experience with 105 patients (1981–1986). Ann Intern Med 108:744–753

    PubMed  CAS  Google Scholar 

  195. Komano J, Maruo S, et al. (1999) Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt’s lymphoma cell line Akata. J Virol 73:9827–9831

    PubMed  CAS  Google Scholar 

  196. Koo C, Rappaport H, et al. (1989) Imprint cytology of non-Hodgkin’s lymphomas. Hum Pathol 20:1–138

    Article  PubMed  CAS  Google Scholar 

  197. Kroft SH (2004) Role of flow cytometry in pediatric hematopathology. Am J Clin Pathol 122Suppl:S19–32

    PubMed  Google Scholar 

  198. Kuefer MU, Look AT, et al. (1997) Retrovirus-mediated gene transfer of NPM-ALK causes lymphoid malignancy in mice. Blood 90:2901–2910

    PubMed  CAS  Google Scholar 

  199. Kuppers R, Schwering I, et al. (2002) Biology of Hodgkin’s lymphoma. Ann Oncol 13Suppl 1:11–18

    PubMed  Google Scholar 

  200. Kurki S, Peltonen K, et al. (2004) Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 5:465–475

    Article  PubMed  CAS  Google Scholar 

  201. Ladanyi M (1997) The NPM/ALK gene fusion in the pathogenesis of anaplastic large cell lymphoma. Cancer Surv 30:59–75

    PubMed  CAS  Google Scholar 

  202. Lamant L, Meggetto F, et al. (1996) High incidence of the t(2;5)(p23;q35) translocation in anaplastic large cell lymphoma and its lack of detection in Hodgkin’s disease. Comparison of cytogenetic analysis, reverse tran-scriptase-polymerase chain reaction, and P-80 immunostaining. Blood 87:284–291

    PubMed  CAS  Google Scholar 

  203. Lambertenghi-Deliliers G, Annaloro C, et al. (1992) Incidence and histological features of bone marrow involvement in malignant lymphomas. Ann Hematol 65:61–65

    Article  PubMed  CAS  Google Scholar 

  204. Langdon WY, Harris AW, et al. (1986) The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 47:11–18

    Article  PubMed  CAS  Google Scholar 

  205. Larson RC, Lavenir I, et al. (1996) Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. Embo J 15:1021–1027

    PubMed  CAS  Google Scholar 

  206. Larsson LG, Pettersson M, et al. (1994) Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc. Oncogene 9:1247–1252

    PubMed  CAS  Google Scholar 

  207. Lawrence HJ, Largman C (1992) Homeobox genes in normal hematopoiesis and leukemia. Blood 80:2445–2453

    PubMed  CAS  Google Scholar 

  208. Lecuyer E, Herblot S, et al. (2002) The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood 100:2430–2440

    Article  PubMed  CAS  Google Scholar 

  209. Lehrmann H, Pritchard LL, et al. (2002) Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv Cancer Res 86:41–65

    PubMed  CAS  Google Scholar 

  210. Leoncini L, Del Vecchio MT, et al. (1990) Hodgkin’s disease and CD30-positive anaplastic large cell lymphomas—a continuous spectrum of malignant disorders. A quantitative morphometric and immunohistologic study. Am J Pathol 137:1047–1057

    PubMed  CAS  Google Scholar 

  211. Liao EC, Paw BH, et al. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes Dev 12:621–626

    PubMed  CAS  Google Scholar 

  212. Lin P, Jones D, et al. (2000) Precursor B-cell lymphoblastic lymphoma: a predominantly extranodal tumor with low propensity for leukemic involvement. Am J Surg Pathol 24:1480–1490

    Article  PubMed  CAS  Google Scholar 

  213. List AF, Greco FA, et al. (1987) Lymphoproliferative diseases in immunocompromised hosts: the role of Epstein-Barr virus. J Clin Oncol 5:1673–1689

    PubMed  CAS  Google Scholar 

  214. Liu ES, Bernstein JM, et al. (2001) Fine needle aspiration biopsy of pediatric head and neck masses. Int J Pediatr Otorhinolaryngol 60:135–140

    Article  PubMed  CAS  Google Scholar 

  215. Lombardi L, Newcomb EW, et al. (1987) Pathogenesis of Burkitt lymphoma: expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts. Cell 49:161–170

    Article  PubMed  CAS  Google Scholar 

  216. Lones MA, Auperin A, et al. (2000) Mature B-cell lymphoma/leukemia in children and adolescents: intergroup pathologist consensus with the revised European-American Lymphoma Classification. Ann Oncol 11:47–51

    Article  PubMed  CAS  Google Scholar 

  217. Lones MA, Perkins SL, et al. (2000) Large-cell lymphoma arising in the mediastinum in children and adolescents is associated with an excellent outcome: a Children’s Cancer Group report. J Clin Oncol 18:3845–3853

    PubMed  CAS  Google Scholar 

  218. Lones MA, Sanger WG, et al. (2004) Chromosome Abnormalities May Correlate With Prognosis in Burkitt/Burkitt-Like Lymphomas of Children and Adolescents. J Pediatr Hematol Oncol 26:169–178

    Article  PubMed  Google Scholar 

  219. Lossos IS, Alizadeh AA, et al. (2000) Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. Proc Natl Acad Sci U S A 97:10209–10213

    Article  PubMed  CAS  Google Scholar 

  220. Lu M, Gong ZY, et al. (1991) The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein. Embo J 10:2905–2910

    PubMed  CAS  Google Scholar 

  221. Lyons SF, Liebowitz DN (1998) The roles of human viruses in the pathogenesis of lymphoma. Semin Oncol 25:461–475

    PubMed  CAS  Google Scholar 

  222. Macdonald D, Aguiar RC, et al. (1995) A new myeloproliferative disorder associated with chromosomal translocations involving 8p11: a review. Leukemia 9:1628–1630

    PubMed  CAS  Google Scholar 

  223. Macdonald D, Reiter A, et al. (2002) The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. Acta Haematol 107:101–107

    Article  PubMed  CAS  Google Scholar 

  224. Macgrogan G, Vergier B, et al. (1996) CD30-positive cutaneous large cell lymphomas. A comparative study of clinicopathologic and molecular features of 16 cases. Am J Clin Pathol 105:440–450

    PubMed  CAS  Google Scholar 

  225. MacLennan IC (1994) Germinal centers. Annu Rev Immunol 12:117–139

    Article  PubMed  CAS  Google Scholar 

  226. Macpherson N, Lesak D, et al. (1999) Small noncleaved, non-Burkitt’s (Burkitt-like) lymphoma: cytogenetics predict outcome and reflect clinical presentation. J Clin Oncol 17:1558–1567

    PubMed  CAS  Google Scholar 

  227. Magrath I (1990) The pathogenesis of Burkitt’s lymphoma. Adv Cancer Res 55:133–270

    Article  PubMed  CAS  Google Scholar 

  228. Magrath I (1997) Small noncleaved cell lymphomas (Burkitt and Burkitt-like lymphomas), 2nd edition, p. 781–811. New York: Arnold

    Google Scholar 

  229. Magrath IT (1991) African Burkitt’s lymphoma. History, biology, clinical features, and treatment. Am J Pediatr Hematol Oncol 13:222–246

    PubMed  CAS  Google Scholar 

  230. Mahajan MA, Park ST, et al. (1996) Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins. Oncogene 12:2343–2350

    PubMed  CAS  Google Scholar 

  231. Maillard I, He Y, et al. (2003) From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. Immunity 18:587–589

    Article  PubMed  CAS  Google Scholar 

  232. Maitra A, McKenna RW, et al. (2001) Precursor B-cell lymphoblastic lymphoma. A study of nine cases lacking blood and bone marrow involvement and review of the literature. Am J Clin Pathol 115:868–875

    Article  PubMed  CAS  Google Scholar 

  233. Mann R, Jaffe E, et al. (1976) Non-endemic Burkitt’s lymphoma: a B-cell tumor related to germinal centers. N Engl J Med 295:685–691

    Article  PubMed  CAS  Google Scholar 

  234. Manolov G, Manolova Y (1972) Marker band in one chromosome 14 from Burkitt lymphomas. Nature 237:33–34

    Article  PubMed  CAS  Google Scholar 

  235. Marcu KB, Harris LJ, et al. (1983) Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia. Proc Natl Acad Sci U S A 80:519–523

    Article  PubMed  CAS  Google Scholar 

  236. Marcucci G, Caligiuri MA, et al. (2003) Core binding factor (CBF) acute myeloid leukemia: is molecular monitoring by RT-PCR useful clinically? Eur J Haematol 71:143–154

    Article  PubMed  CAS  Google Scholar 

  237. Marti GE, Stetler-Stevenson M, et al. (2001) Introduction to flow cytometry. Semin Hematol 38:93–99

    Article  PubMed  CAS  Google Scholar 

  238. Mason DY, Pulford KA, et al. (1998) Nucleolar localization of the nucleophosmin-anaplastic lymphoma kinase is not required for malignant transformation. Cancer Res 58:1057–1062

    PubMed  CAS  Google Scholar 

  239. Massimino M, Gasparini M, et al. (1995) Ki-1 (CD30) anaplastic large-cell lymphoma in children. Ann Oncol 6:915–920

    PubMed  CAS  Google Scholar 

  240. Mathew P, Sanger WG, et al. (1997) Detection of the t(2;5)(p23;q35) and NPM-ALK fusion in non-Hodgkin’s lymphoma by two-color fluorescence in situ hybridization. Blood 89:1678–1685

    PubMed  CAS  Google Scholar 

  241. Mauvieux L, Leymarie V, et al. (2002) High incidence of Hox11L2 expression in children with T-ALL. Leukemia 16:2417–2422

    Article  PubMed  CAS  Google Scholar 

  242. McCoy JP, Jr. (2002) Basic principles of flow cytometry. Hematol Oncol Clin North Am 16:229–243

    Article  PubMed  Google Scholar 

  243. McGahey B, Moriarty A, et al. (1992) Fine-needle aspiration biopsy of small round blue cell tumors of childhood. Cancer 69:1067–1073

    Article  PubMed  CAS  Google Scholar 

  244. McGuire EA, Hockett RD, et al. (1989) The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol 9:2124–2132

    PubMed  CAS  Google Scholar 

  245. McKeithan TW, Shima EA, et al. (1986) Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3′ side of MYC. Proc Natl Acad Sci U S A 83:6636–6640

    Article  PubMed  CAS  Google Scholar 

  246. McMahon SB, Van Buskirk HA, et al. (1998) The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94:363–374

    Article  PubMed  CAS  Google Scholar 

  247. McMahon SB, Wood MA, et al. (2000) The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol 20:556–562

    Article  PubMed  CAS  Google Scholar 

  248. Mellentin JD, Smith SD, et al. (1989) lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 58:77–83

    Article  PubMed  CAS  Google Scholar 

  249. Melphan B (1982) Effects of fixatives on the immunoreactivity of paraffin sections. Histochem J 14:731–737

    Article  Google Scholar 

  250. Migliazza A, Martinotti S, et al. (1995) Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A 92:12520–12524

    Article  PubMed  CAS  Google Scholar 

  251. Miki T, Kawamata N, et al. (1994) Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias. Blood 83:217–222

    PubMed  CAS  Google Scholar 

  252. Mikkola HK, Klintman J, et al. (2003) Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem cell leukaemia SCL/tal-1 gene. Nature 421:547–551

    Article  PubMed  CAS  Google Scholar 

  253. Miyamoto A, Cui X, et al. (1996) Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells. Mol Cell Biol 16:2394–2401

    PubMed  CAS  Google Scholar 

  254. Morris SW, Kirstein MN, et al. (1994) Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma. Science 263:1281–1284

    Article  PubMed  CAS  Google Scholar 

  255. Morris SW, Naeve C, et al. (1997) ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin’s lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14:2175–2188

    Article  PubMed  CAS  Google Scholar 

  256. Morris SW, Xue L, et al. (2001) Alk+ CD30+ lymphomas: a distinct molecular genetic subtype of non-Hodgkin’s lymphoma. Br J Haematol 113:275–295

    Article  PubMed  CAS  Google Scholar 

  257. Mouthon MA, Bernard O, et al. (1993) Expression of tal-1 and GATA-binding proteins during human hematopoiesis. Blood 81:647–655

    PubMed  CAS  Google Scholar 

  258. Mrozek K, Heinonen K, et al. (2001) Clinical importance of cytogenetics in acute myeloid leukaemia. Best Pract Res Clin Haematol 14:19–47

    Article  PubMed  CAS  Google Scholar 

  259. Murphy S (1980) Classification, staging and end results of treatment of childhood non-Hodgkinn’s lymphomas: Dissimilarities from lymphomas in adults. Semin Oncol 7:332–338

    PubMed  CAS  Google Scholar 

  260. Murre C (2000) Intertwining proteins in thymocyte development and cancer. Nat Immunol 1:97–98

    Article  PubMed  CAS  Google Scholar 

  261. Murre C, McCaw PS, et al. (1989) Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58:537–544

    Article  PubMed  CAS  Google Scholar 

  262. Nakagawa A, Nakamura S, et al. (1997) CD30-positive anaplastic large cell lymphoma in childhood: expression of p80npm/alk and absence of Epstein-Barr virus. Mod Pathol 10:210–215

    PubMed  CAS  Google Scholar 

  263. Nanjangud G, Rao PH, et al. (2002) Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma. Blood 99:2554–2561

    Article  PubMed  CAS  Google Scholar 

  264. Neri A, Barriga F, et al. (1991) Epstein-Barr virus infection precedes clonal expansion in Burkitt’s and acquired immunodeficiency syndrome-associated lymphoma. Blood 77:1092–1095

    PubMed  CAS  Google Scholar 

  265. Oertel J, Huhn D (2000) Immunocytochemical methods in haematology and oncology. J Cancer Res Clin Oncol 126:425–440

    PubMed  CAS  Google Scholar 

  266. Offit K, Jhanwar S, et al. (1989) t(3;22)(q27;q11): a novel translocation associated with diffuse non-Hodgkin’s lymphoma. Blood 74:1876–1879

    PubMed  CAS  Google Scholar 

  267. Offit K, Lo Coco F, et al. (1994) Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. N Engl J Med 331:74–80

    Article  PubMed  CAS  Google Scholar 

  268. O’Hara C, Said J, et al. (1986) Non-Hodgkin’s lymphoma, multilobated B-cell type: report of nine cases with immunohistochemical and immunoultrastructural evidence of a follicular center cell derivation. Hum Pathol 17:593–599

    Article  PubMed  CAS  Google Scholar 

  269. Ohno H, Kerckaert JP, et al. (1994) Heterogeneity in B-cell neoplasms associated with rearrangement of the LAZ3 gene on chromosome band 3q27. Jpn J Cancer Res 85:592–600

    PubMed  CAS  Google Scholar 

  270. Okuda M, Horn HF, et al. (2000) Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103:127–140

    Article  PubMed  CAS  Google Scholar 

  271. Omichinski JG, Clore GM, et al. (1993) NMR structure of a specific DNA complex of Zn-containing DNA binding domain of GATA-1. Science 261:438–446

    Article  PubMed  CAS  Google Scholar 

  272. Onciu M, Behm FG, et al. (2003) ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases. Blood 102:2642–2644

    Article  PubMed  CAS  Google Scholar 

  273. Onciu M, Behm FG, et al. (2003) ALK-positive anaplastic large cell lymphoma with leukemic peripheral blood involvement is a clinicopathologic entity with an unfavorable prognosis. Report of three cases and review of the literature. Am J Clin Pathol 120:617–625

    Article  PubMed  Google Scholar 

  274. Onciu M, Lorsbach RB, et al. (2002) Terminal deoxynucleotidyl transferase-positive lymphoid cells in reactive lymph nodes from children with malignant tumors: incidence, distribution pattern, and immunophenotype in 26 patients. Am J Clin Pathol 118:248–254

    Article  PubMed  CAS  Google Scholar 

  275. O’Neil J, Billa M, et al. (2001) The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. Oncogene 20:3897–3905

    Article  PubMed  CAS  Google Scholar 

  276. Onizuka T, Moriyama M, et al. (1995) BCL-6 gene product, a 92-to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86:28–37

    PubMed  CAS  Google Scholar 

  277. Ono Y, Fukuhara N, et al. (1997) Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (TALL) requires RBTN1 or-2 and induces TALLA1, a highly specific tumor marker of T-ALL. J Biol Chem 272:4576–4581

    Article  PubMed  CAS  Google Scholar 

  278. Ono Y, Fukuhara N, et al. (1998) TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol 18:6939–6950

    PubMed  CAS  Google Scholar 

  279. Osada H, Grutz G, et al. (1995) Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. Proc Natl Acad Sci U S A 92:9585–9589

    Article  PubMed  CAS  Google Scholar 

  280. Otsuki T, Yano T, et al. (1995) Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkin’s lymphomas: results of rearrangement and gene expression studies and a mutational analysis of coding region sequences. Blood 85:2877–2884

    PubMed  CAS  Google Scholar 

  281. Packham G, Cleveland JL (1995) c-Myc and apoptosis. Biochim Biophys Acta 1242:11–28

    PubMed  Google Scholar 

  282. Patrick CW (2002) Clinical flow cytometry: milestones along the pathway of progress. MLO Med Lab Obs 34:10–11, 14–16; quiz 20–11

    PubMed  Google Scholar 

  283. Pear WS, Aster JC (2004) T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. Curr Opin Hematol 11:426–433

    Article  PubMed  CAS  Google Scholar 

  284. Pear WS, Aster JC, et al. (1996) Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 183:2283–2291

    Article  PubMed  CAS  Google Scholar 

  285. Pelicci PG, Knowles DM, 2nd, et al. (1986) Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci U S A 83:2984–2988

    Article  PubMed  CAS  Google Scholar 

  286. Penn I (1986) Cancer is a complication of severe immunosuppression. Surg Gynecol Obstet 162:603–610

    PubMed  CAS  Google Scholar 

  287. Perez-Alvarado GC, Miles C, et al. (1994) Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat Struct Biol 1:388–398

    Article  PubMed  CAS  Google Scholar 

  288. Perkins S, Kjeldsberg C (1993) Immunophenotyping of lymphomas and leukemias in paraffin-embedded tissues. Am J Clin Pathol 99:362–372

    PubMed  CAS  Google Scholar 

  289. Perkins SL (2000) Work-up and diagnosis of pediatric non-Hodgkin’s lymphomas. Pediatr Dev Pathol 3:374–390

    Article  PubMed  CAS  Google Scholar 

  290. Perkins SL, Segal GH, et al. (1995) Classification of non-Hodgkin’s lymphomas in children. Semin Diagn Pathol 12:303–313

    PubMed  CAS  Google Scholar 

  291. Pevny L, Simon MC, et al. (1991) Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature 349:257–260

    Article  PubMed  CAS  Google Scholar 

  292. Picozzi VJ, Jr., Coleman CN (1990) Lymphoblastic lymphoma. Semin Oncol 17:96–103

    PubMed  Google Scholar 

  293. Piira T, Perkins S, et al. (1995) Primary mediastinal large cell lymphoma in children: a report from the Children’s Cancer Group. Ped Pathol Lab Med 15:561–570

    CAS  Google Scholar 

  294. Pileri SA, Dirnhofer S, et al. (2002) Diffuse large B-cell lymphoma: one or more entities? Present controversies and possible tools for its subclassification. Histopathology 41:482–509

    Article  PubMed  CAS  Google Scholar 

  295. Pilozzi E, Muller-Hermelink HK, et al. (1999) Gene rearrangements in T-cell lymphoblastic lymphoma. J Pathol 188:267–270

    Article  PubMed  CAS  Google Scholar 

  296. Polo JM, Dell’Oso T, et al. (2004) Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 10:1329–1335

    Article  PubMed  CAS  Google Scholar 

  297. Popovici C, Adelaide J, et al. (1998) Fibroblast growth factor receptor 1 is fused to FIM in stem cell myeloproliferative disorder with t(8;13). Proc Natl Acad Sci U S A 95:5712–5717

    Article  PubMed  CAS  Google Scholar 

  298. Porcher C, Liao EC, et al. (1999) Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding. Development 126:4603–4615

    PubMed  CAS  Google Scholar 

  299. Porcher C, Swat W, et al. (1996) The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 86:47–57

    Article  PubMed  CAS  Google Scholar 

  300. Potter MN (1992) The detection of minimal residual disease in acute lymphoblastic leukemia. Blood Rev 6:68–82

    Article  PubMed  CAS  Google Scholar 

  301. Preciado MV, Fallo A, et al. (2002) Epstein Barr virus-associated lymphoma in HIV-infected children. Pathol Res Pract 198:327–332

    Article  PubMed  Google Scholar 

  302. Prendergast GC, Lawe D, et al. (1991) Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras co-transformation. Cell 65:395–407

    Article  PubMed  CAS  Google Scholar 

  303. Prochownik EV, Kukowska J, et al. (1988) c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells. Mol Cell Biol 8:3683–3695

    PubMed  CAS  Google Scholar 

  304. Pui JC, Allman D, et al. (1999) Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11:299–308

    Article  PubMed  CAS  Google Scholar 

  305. Pulford K, Lamant L, et al. (2004) The emerging normal and disease-related roles of anaplastic lymphoma kinase. Cell Mol Life Sci 61:2939–2953

    Article  PubMed  CAS  Google Scholar 

  306. Pulford K, Lamant L, et al. (1997) Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1. Blood 89:1394–1404

    PubMed  CAS  Google Scholar 

  307. Pulford K, Lecointe N, et al. (1995) Expression of TAL-1 proteins in human tissues. Blood 85:675–684

    PubMed  CAS  Google Scholar 

  308. Pulford K, Morris SW, et al. (2004) Anaplastic lymphoma kinase proteins in growth control and cancer. J Cell Physiol 199:330–358

    Article  PubMed  CAS  Google Scholar 

  309. Purtilo DT, Stevenson M (1991) Lymphotropic viruses as etiologic agents of lymphoma. Hematol Oncol Clin North Am 5:901–923

    PubMed  CAS  Google Scholar 

  310. Quong MW, Romanow WJ, et al. (2002) E protein function in lymphocyte development. Annu Rev Immunol 20:301–322

    Article  PubMed  CAS  Google Scholar 

  311. Rabbitts TH (1998) LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Genes Dev 12:2651–2657

    PubMed  CAS  Google Scholar 

  312. Rabbitts TH, Boehm T (1991) Structural and functional chimerism results from chromosomal translocation in lymphoid tumors. Adv Immunol 50:119–146

    Article  PubMed  CAS  Google Scholar 

  313. Rabbitts TH, Bucher K, et al. (1999) The effect of chromosomal translocations in acute leukemias: the LMO2 paradigm in transcription and development. Cancer Res 59:1794s–1798s

    PubMed  CAS  Google Scholar 

  314. Rabbitts TH, Hamlyn PH, et al. (1983) Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature 306:760–765

    Article  PubMed  CAS  Google Scholar 

  315. Radtke F, Wilson A, et al. (2004) Notch signaling in T-and B-cell development. Curr Opin Immunol 16:174–179

    Article  PubMed  CAS  Google Scholar 

  316. Radtke F, Wilson A, et al. (2004) Notch regulation of lymphocyte development and function. Nat Immunol 5:247–253

    Article  PubMed  CAS  Google Scholar 

  317. Raimondi SC (2000) Fluorescence in situ hybridization: molecular probes for diagnosis of pediatric neoplastic diseases. Cancer Invest 18:135–147

    PubMed  CAS  Google Scholar 

  318. Rappaport H Tumors of the hematopoietic system., vol. 8. Washington D.C.: US Armed Forces Institute of Pathology, 1966

    Google Scholar 

  319. Rappold GA, Hameister H, et al. (1984) c-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations. Embo J 3:2951–2955

    PubMed  CAS  Google Scholar 

  320. Reddy KS, Perkins SL (2004) Advances in the diagnostic approach to childhood lymphoblastic malignant neoplasms. Am J Clin Pathol 122Suppl:S3–18

    PubMed  Google Scholar 

  321. Redner RL, Wang J, et al. (1999) Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94:417–428

    PubMed  CAS  Google Scholar 

  322. Reid MM, Roald B (1996) Adequacy of bone marrow trephine biopsy specimens in children. J Clin Pathol 49:226–229

    PubMed  CAS  Google Scholar 

  323. Reiter A, Sohal J, et al. (1998) Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome. Blood 92:1735–1742

    PubMed  CAS  Google Scholar 

  324. Robb L, Lyons I, et al. (1995) Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A 92:7075–7079

    Article  PubMed  CAS  Google Scholar 

  325. Roberts CW, Shutter JR, et al. (1994) Hox11 controls the genesis of the spleen. Nature 368:747–749

    Article  PubMed  CAS  Google Scholar 

  326. Robertson SM, Kennedy M, et al. (2000) A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1. Development 127:2447–2459

    PubMed  CAS  Google Scholar 

  327. Rosenwald A, Wright G, et al. (2002) The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med 346:1937–1947

    Article  PubMed  Google Scholar 

  328. Rowland JM (2002) Molecular genetic diagnosis of pediatric cancer: current and emerging methods. Pediatr Clin North Am 49:1415–1435

    Article  PubMed  Google Scholar 

  329. Rowley JD, Aster JC, et al. (1993) The clinical applications of new DNA diagnostic technology on the management of cancer patients. Jama 270:2331–2337

    Article  PubMed  CAS  Google Scholar 

  330. Royer-Pokora B, Loos U, et al. (1991) TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14) (p13;q11). Oncogene 6:1887–1893

    PubMed  CAS  Google Scholar 

  331. Rudd CE (1990) CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor. Immunol Today 11:400–406

    Article  PubMed  CAS  Google Scholar 

  332. Rudd CE, Trevillyan JM, et al. (1988) The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci U S A 85:5190–5194

    Article  PubMed  CAS  Google Scholar 

  333. Sakamuro D, Prendergast GC (1999) New Myc-interacting proteins: a second Myc network emerges. Oncogene 18:2942–2954

    Article  PubMed  CAS  Google Scholar 

  334. Saleh A, Schieltz D, et al. (1998) Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 273:26559–26565

    Article  PubMed  CAS  Google Scholar 

  335. Sanchez-Garcia I, Axelson H, et al. (1995) Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2. Oncogene 10:1301–1306

    PubMed  CAS  Google Scholar 

  336. Sanchez-Garcia I, Rabbitts TH (1994) The LIM domain: a new structural motif found in zinc-finger-like proteins. Trends Genet 10:315–320

    Article  PubMed  CAS  Google Scholar 

  337. Sandlund JT, Downing IT Lymphoblastic lymphoma, 2 edition, p. 813–828. New York: Arnold, 1997

    Google Scholar 

  338. Sandlund JT, Downing JR, et al. (1996) Non-Hodgkin’s lymphoma in childhood. N Engl J Med 334:1238–1248

    Article  PubMed  CAS  Google Scholar 

  339. Sanger W (2003) Primary (8q24) and Secondary Chromosome Abnormalities (1q, 6q, 13q, & 17p) are Similar in Pediatric Burkitt Lymphoma/Burkitt Leukemia & Burkitt-like Lymphoma: A Report of the International Pediatric B-cell Non-Hodgkin Lymphoma Study. Blood 102:845a

    Google Scholar 

  340. Sarris AH, Luthra R, et al. (1996) Amplification of genomic DNA demonstrates the presence of the t(2;5) (p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin’s lymphomas, Hodgkin’s disease, or lymphomatoid papulosis. Blood 88:1771–1779

    PubMed  CAS  Google Scholar 

  341. Schmidt-Zachmann MS, Franke WW (1988) DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli. Correspondence of the nucleoplasmin-related protein N 38 to mammalian protein B23. Chromosoma 96:417–426

    Article  PubMed  CAS  Google Scholar 

  342. Schmidt-Zachmann MS, Hugle-Dorr B, et al. (1987) A constitutive nucleolar protein identified as a member of the nucleoplasmin family. Embo J 6:1881–1890

    PubMed  CAS  Google Scholar 

  343. Schreiber-Agus N, Chin L, et al. (1995) An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80:777–786

    Article  PubMed  CAS  Google Scholar 

  344. Seidemann K, Tiemann M, et al. (2003) Primary mediastinal large B-cell lymphoma with sclerosis in pediatric and adolescent patients: treatment and results from three therapeutic studies of the Berlin-Frankfurt-Munster Group. J Clin Oncol 21:1782–1789

    Article  PubMed  CAS  Google Scholar 

  345. Seiter K (2003) Diagnosis and management of core-binding factor leukemias. Curr Hematol Rep 2:78–85

    PubMed  Google Scholar 

  346. Sen F, Vega F, et al. (2002) Molecular genetic methods in the diagnosis of hematologic neoplasms. Semin Diagn Pathol 19:72–93

    PubMed  Google Scholar 

  347. Sharp JG, Chan WC (1999) Detection and relevance of minimal disease in lymphomas. Cancer Metastasis Rev 18:127–142

    Article  PubMed  CAS  Google Scholar 

  348. Sheibani K, Nathwani B, et al. (1987) Antigenically defined subgroups of lymphoblastic lymphoma: relationship to clinical presentation and biologic behavior. Cancer 60:183–190

    Article  PubMed  CAS  Google Scholar 

  349. Sherman CG, Zielenska M, et al. (2001) Morphological and phenotypic features in pediatric large cell lymphoma and their correlation with ALK expression and the t(2;5)(p23;q35) translocation. Pediatr Dev Pathol 4:129–137

    Article  PubMed  CAS  Google Scholar 

  350. Shibuya H, Yoneyama M, et al. (1992) IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell 70:57–67

    Article  PubMed  CAS  Google Scholar 

  351. Shim H, Dolde C, et al. (1997) c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A 94:6658–6663

    Article  PubMed  CAS  Google Scholar 

  352. Shima EA, Le Beau MM, et al. (1986) Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia. Proc Natl Acad Sci U S A 83:3439–3443

    Article  PubMed  CAS  Google Scholar 

  353. Shiota M, Fujimoto J, et al. (1994) Hyperphosphorylation of a novel 80 kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3. Oncogene 9:1567–1574

    PubMed  CAS  Google Scholar 

  354. Shiota M, Fujimoto J, et al. (1994) Diagnosis of t(2;5)(p23;q35)-associated Ki-1 lymphoma with immunohistochemistry. Blood 84:3648–3652

    PubMed  CAS  Google Scholar 

  355. Shiota M, Nakamura S, et al. (1995) Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity. Blood 86:1954–1960

    PubMed  CAS  Google Scholar 

  356. Shipp MA, Ross KN, et al. (2002) Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med 8:68–74

    Article  PubMed  CAS  Google Scholar 

  357. Shivdasani RA, Mayer EL, et al. (1995) Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature 373:432–434

    Article  PubMed  CAS  Google Scholar 

  358. Siebert R, Rosenwald A, et al. (2001) Molecular features of B-cell lymphoma. Curr Opin Oncol 13:316–324

    Article  PubMed  CAS  Google Scholar 

  359. Sklar J, Longtine J (1992) The clinical significance of antigen receptor gene rearrangements in lymphoid neoplasia. Cancer 70:1710–1718

    Article  PubMed  CAS  Google Scholar 

  360. Smedley D, Hamoudi R, et al. (1998) The t(8;13)(p11;q11–12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. Hum Mol Genet 7:637–642

    Article  PubMed  CAS  Google Scholar 

  361. Solomon AC, Kossev PM (2002) Frozen sections in hematopathology. Semin Diagn Pathol 19:255–262

    PubMed  Google Scholar 

  362. Sommer A, Hilfenhaus S, et al. (1997) Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity. Curr Biol 7:357–365

    Article  PubMed  CAS  Google Scholar 

  363. Soslow R, Baergen R, et al. (1999) B-lineage lymphoblastic lymphoma is a clinicopathologic entity distinct from other histologically aggressive lymphomas with blastic morphology. Cancer 85:2648–2654

    Article  PubMed  CAS  Google Scholar 

  364. Soslow R, Bhargava V, et al. (1997) MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high grade lymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities. Hum Pathol 28:1158–1165

    Article  PubMed  CAS  Google Scholar 

  365. Spina D, Leoncini L, et al. (1997) Cellular kinetic and phenotypic heterogeneity in and among Burkitt’s and Burkitt-like lymphomas. J Pathol 182:145–150

    Article  PubMed  CAS  Google Scholar 

  366. Srinivasan M, Sedmak D, et al. (2002) Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Am J Pathol 161:1961–1971

    PubMed  CAS  Google Scholar 

  367. Staudt LM (2003) Molecular diagnosis of the hematologic cancers. N Engl J Med 348:1777–1785

    Article  PubMed  CAS  Google Scholar 

  368. Suzumiya J, Oshima K, et al. (1997) Terminal deoxytidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. J Pathol 182:86–91

    Article  PubMed  CAS  Google Scholar 

  369. Swansbury J (2003) Cytogenetic and genetic studies in solid tumors: background. Methods Mol Biol 220:125–133

    PubMed  CAS  Google Scholar 

  370. Swansbury J (2003) Cytogenetic studies in hematologic malignancies: an overview. Methods Mol Biol 220:9–22

    PubMed  Google Scholar 

  371. Swerdlow SH (2004) Pediatric follicular lymphomas, marginal zone lymphomas, and marginal zone hyperplasia. Am J Clin Pathol 122Suppl:S98–109

    PubMed  Google Scholar 

  372. Szebeni A, Herrera JE, et al. (1995) Interaction of nucleolar protein B23 with peptides related to nuclear localization signals. Biochemistry 34:8037–8042

    Article  PubMed  CAS  Google Scholar 

  373. Szeles A (2002) Fluorescence in situ hybridization (FISH) in the molecular cytogenetics of cancer. Acta Microbiol Immunol Hung 49:69–80

    Article  PubMed  CAS  Google Scholar 

  374. Tanaka S, Louie DC, et al. (1992) Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin’s lymphomas. Blood 79:229–237

    PubMed  CAS  Google Scholar 

  375. Tang S, Breitman ML (1995) The optimal binding sequence of the Hox11 protein contains a predicted recognition core motif. Nucleic Acids Res 23:1928–1935

    Article  PubMed  CAS  Google Scholar 

  376. Taub R, Kelly K, et al. (1984) A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma. Cell 37:511–520

    Article  PubMed  CAS  Google Scholar 

  377. Taub R, Kirsch I, et al. (1982) Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA 79:7837–7841

    Article  PubMed  CAS  Google Scholar 

  378. Thomas DA, Kantarjian HM (2001) Lymphoblastic lymphoma. Hematol Oncol Clin North Am 15:51–95, vi

    Article  PubMed  CAS  Google Scholar 

  379. Traxler P (2003) Tyrosine kinases as targets in cancer therapy — successes and failures. Expert Opin Ther Targets 7:215–234

    Article  PubMed  CAS  Google Scholar 

  380. Tubbs RR, Sheibani K (1984) Immunohistology of lymphoproliferative disorders. Semin Diagn Pathol 1:272–284

    PubMed  CAS  Google Scholar 

  381. Tycko B, Smith SD, et al. (1991) Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia. J Exp Med 174:867–873

    Article  PubMed  CAS  Google Scholar 

  382. Valge-Archer V, Forster A, et al. (1998) The LMO1 AND LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). Oncogene 17:3199–3202

    Article  PubMed  CAS  Google Scholar 

  383. Valge-Archer VE, Osada H, et al. (1994) The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc Natl Acad Sci USA 91:8617–8621

    Article  PubMed  CAS  Google Scholar 

  384. van Krieken JH (2004) Lymphoproliferative disease associated with immune deficiency in children. Am J Clin Pathol 122Suppl:S122–127

    PubMed  Google Scholar 

  385. Veillette A, Bookman MA, et al. (1988) The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 55:301–308

    Article  PubMed  CAS  Google Scholar 

  386. Velez-Garcia E, Durant J, et al. (1983) Results of a uniform histopathologic review system of lymphoma cases. A ten-year study from the Southeastern Cancer Study Group. Cancer 52:675–679

    Article  PubMed  CAS  Google Scholar 

  387. Visvader J, Begley CG, et al. (1991) Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system. Oncogene 6:187–194

    PubMed  CAS  Google Scholar 

  388. Visvader JE, Fujiwara Y, et al. (1998) Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev 12:473–479

    PubMed  CAS  Google Scholar 

  389. Wadman I, Li J, et al. (1994) Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. Embo J 13:4831–4839

    PubMed  CAS  Google Scholar 

  390. Wadman IA, Osada H, et al. (1997) The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. Embo J 16:3145–3157

    Article  PubMed  CAS  Google Scholar 

  391. Waggott W, Lo YM, et al. (1995) Detection of NPM-ALK DNA rearrangement in CD30 positive anaplastic large cell lymphoma. Br J Haematol 89:905–907

    Article  PubMed  CAS  Google Scholar 

  392. Wang J, Xie LY, et al. (1998) Myc activates telomerase. Genes Dev 12:1769–1774

    PubMed  CAS  Google Scholar 

  393. Weber-Matthiesen K, Deerberg-Wittram J, et al. (1996) Translocation t(2;5) is not a primary event in Hodgkin’s disease. Simultaneous immunophenotyping and interphase cytogenetics. Am J Pathol 149:463–468

    PubMed  CAS  Google Scholar 

  394. Weir EG, Borowitz MJ (2001) Flow cytometry in the diagnosis of acute leukemia. Semin Hematol 38:124–138

    Article  PubMed  CAS  Google Scholar 

  395. Weisberger J, Wu CD, et al. (2000) Differential diagnosis of malignant lymphomas and related disorders by specific pattern of expression of immunophenotypic markers revealed by multiparameter flow cytometry (Review). Int J Oncol 17:1165–1177

    PubMed  CAS  Google Scholar 

  396. Weiss L, Chen Y-Y (1991) Effects of different fixatives on detection of nucleic acids from paraffin-embedded tissues by in situ hybridization using oligonucleotide probes. J Histochem Cytochem 39:1237–1242

    PubMed  CAS  Google Scholar 

  397. Wellmann A, Otsuki T, et al. (1995) Analysis of the t(2;5)(p23;q35) translocation by reverse transcription-polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin’s lymphomas of T-cell phenotype, and in Hodgkin’s disease. Blood 86:2321–2328

    PubMed  CAS  Google Scholar 

  398. Weng AP, Ferrando AA, et al. (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306:269–271

    Article  PubMed  CAS  Google Scholar 

  399. Weng AP, Nam Y, et al. (2003) Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 23:655–664

    Article  PubMed  CAS  Google Scholar 

  400. Wick M, Zubov D, et al. (1999) Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 232:97–106

    Article  PubMed  CAS  Google Scholar 

  401. Wilson J, Kjeldsberg C, et al. (1987) The pathology of non-Hodgkin’s lymphoma of childhood: reproducibility and relevance of the histologic classification of “undifferentiated” lymphomas (Burkitt’s versus non-Burkitts). Hum Pathol 18:1008–1014

    Article  PubMed  CAS  Google Scholar 

  402. Wilson JB, Bell JL, et al. (1996) Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice. Embo J 15:3117–3126

    PubMed  CAS  Google Scholar 

  403. Wong GT, Manfra D, et al. (2004) Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 279:12876–12882

    Article  PubMed  CAS  Google Scholar 

  404. Wright D, McKeever P, et al. (1997) Childhood non-Hodgkin’s lymphomas in the United Kingdom: findings from the UK Children’s Cancer Study Group. J Clin Pathol 50:128–134

    PubMed  CAS  Google Scholar 

  405. Wright DD, Sefton BM, et al. (1994) Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. Mol Cell Biol 14:2429–2437

    PubMed  CAS  Google Scholar 

  406. Wu KJ, Grandori C, et al. (1999) Direct activation of TERT transcription by c-MYC. Nat Genet 21:220–224

    Article  PubMed  CAS  Google Scholar 

  407. Xia Y, Brown L, et al. (1991) TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc Natl Acad Sci U S A 88:11416–11420

    Article  PubMed  CAS  Google Scholar 

  408. Xiao S, Nalabolu SR, et al. (1998) FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome. Nat Genet 18:84–87

    Article  PubMed  CAS  Google Scholar 

  409. Yamada Y, Pannell R, et al. (2000) The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci USA 97:320–324

    Article  PubMed  CAS  Google Scholar 

  410. Yamamoto H, Hatano M, et al. (1995) Two forms of Hox11, a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes. Mol Immunol 32:1177–1182

    Article  PubMed  CAS  Google Scholar 

  411. Ye BH, Chaganti S, et al. (1995) Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. Embo J 14:6209–6217

    PubMed  CAS  Google Scholar 

  412. Ye BH, Rao PH, et al. (1993) Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma. Cancer Res 53:2732–2735

    PubMed  CAS  Google Scholar 

  413. Younes A, Carbone A (2003) Clinicopathologic and molecular features of Hodgkin’s lymphoma. Cancer Biol Ther 2:500–507

    PubMed  CAS  Google Scholar 

  414. Young L, Alfieri C, et al. (1989) Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med 321:1080–1085

    Article  PubMed  CAS  Google Scholar 

  415. Zamoyska R, Basson A, et al. (2003) The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol Rev 191:107–118

    Article  PubMed  CAS  Google Scholar 

  416. Zech L, Haglund U, et al. (1976) Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. Int J Cancer 17:47–56

    PubMed  CAS  Google Scholar 

  417. Zervos AS, Gyuris J, et al. (1993) Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72:223–232

    Article  PubMed  CAS  Google Scholar 

  418. Zhao Y, Westphal H (2002) Homeobox genes and human genetic disorders. Curr Mol Med 2:13–23

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. University of Utah Health Sciences Center, 50 North Medical Drive, Salt Lake City, Utah, 84132, USA

    S. L. Perkins M.D., Ph. D.

  2. Departments of Pathology and Hematology-Oncology, St. Jude Children’s Research Hospital, Thomas Tower - Room 4026 332 North Lauderdale St., Memphis, TN, 38105, USA

    S. W. Morris M.D.

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  1. S. L. Perkins M.D., Ph. D.
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Editors and Affiliations

  1. Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA

    Howard J. Weinstein

  2. Department of Pediatrics, University of Tennessee Health Science Center College of Medicine, 332 North Lauderdale, Memphis, TN, 28105, USA

    Melissa M. Hudson

  3. Department of Hematology-Oncology, St. Jude Children’s Research Hospital, 332 North Lauderdale, Memphis, TN, 28105, USA

    Melissa M. Hudson

  4. School of Medicine, Department of Hematology-Oncology, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305-5208, USA

    Michael P. Link

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© 2007 Springer-Verlag Berlin Heidelberg

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Perkins, S.L., Morris, S.W. (2007). Biology and Pathology of Pediatric Non-Hodgkin Lymphoma. In: Weinstein, H.J., Hudson, M.M., Link, M.P. (eds) Pediatric Lymphomas. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68753-5_6

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  • DOI: https://doi.org/10.1007/978-3-540-68753-5_6

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