Auszug
Die Entwicklung der Antipsychotika in den 50-er Jahren des letzten Jahrhunderts hat die psychiatrische Therapie revolutioniert. Sie bildete die Grundlage für die Entlassung zahlreicher Patienten mit chronischen Psychosen aus psychiatrischen Großkrankenhäusern in die gemeindenahe psychiatrische Versorgung („Deinstitutionalisierung“). In den USA führte dieser Prozess über einen Zeitraum von ca. 30 Jahren zu einer 80%igen Reduktion der Zahl der Patienten, die in psychiatrischen Groß- und Landeskrankenhäusern untergebracht waren, von 559.000 im Jahr 1955 über 338.000 im Jahr 1970 bis zu 107.000 im Jahr 1988.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literatur
Agid O, Kapur S, Arenovich T, Zipursky RB (2003) Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected. Arch Gen Psychiatry 60: 1228–1235
Alvir JM, Lieberman JA, Safferman AZ, Schwimmer JL, Schaaf JA (1993) Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med 329: 162–167
Arnt J, Skarsfeldt T (1998) Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology 18: 63–101
Baldessarini RJ, Tarazi FI (2006) Pharmacotherapy of psychosis and mania. In: Brunton LL, Lazo JS, Parker KL (eds) Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 11th edn. McGraw-Hill, New York
Benkert O, Hippius H (2007) Kompendium der Psychiatrischen Pharmakotherapie. 6. Aufl., Springer, Berlin-Heldelberg New York
Benkert O, Gründer G, Wetzel H (1992) Dopamine autoreceptor agonists in the treatment of schizophrenia and major depression. Pharmacopsychiatry 25: 254–260
Breier A (1994) Clozapine and noradrenergic function: support for a novel hypothesis for superior efficacy. J Clin Psychiatry 55 (Suppl B): 122–125
Burstein ES, Ma J, Wong S et al (2005) Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J Pharmacol Exp Ther 315: 1278–1287.
Calabrese JR, Keck PE Jr, Macfadden W et al (2005) A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. Am J Psychistry 162: 1351–1360
Carlsson A, Lindqvist M (1963) Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol Toxicol (Copenh) 20: 140–144
Centorrino F, Price BH, Tuttle M, Bahk WM, Hennen J, Albert MJ, Baldessarini RJ (2002) EEG abnormalities during treatment with typical and a typical antipsychotics. Am J Psychiatry 159: 109–115
Ceulemans DL, Gelders YG, Hoppenbrouwers ML, Reyntjens AJ, Janssen PA (1985) Effect of serotonin antagonism in schizophrenia: a pilot study with setoperone. Psychopharmacology Berl 85: 329–332
Chakraborty BS, Hubbard JW, Hawes EM et al (1989) Interconversion between haloperidol and reduced haloperidol in healthy volunteers. Eur J Clin Pharmacol 37: 45–48.
Chlodo LA, Bunney BS (1985) Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. J Neurosci 5: 2539–2544
Chou YH, Halldin C, Farde L (2006) Clozapine binds preferentially to cortical D1-like dopamine receptors in the primate brain: a PET study. Psychopharmacology 185: 29–35
Correll CU, Leucht S, Kane JM (2004) Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies. Am J Psychiatry 161: 414–425
Davis JM, Chen N, Glick ID (2004) A meta-analysis of the efficacy of second-generation antipsychotics. Arch Gen Psychiatry 60: 553–564
Elkes J, Elkes C (1954) Effect of chlorpromazine on the behaviour of chronically over-active psychotic patients. Br Med J 2: 560–565
Farde L, Nordström AL, Wiesel FA, Pauli S, Halldin C, Sedvall G (1992) Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 49: 538–544
Farde L, Nyberg S, Oxenstierna G, Nakashima Y, Halldin C, Ericsson B (1995) Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients. J Clin Psychopharmacol 15: 19s–23s
Farver DK (2003) Neuroleptic malignant syndrome induced by atypical antipsychotics. Expert Opin Drug Saf 2: 21–35
Geyer MA, Ellenbroeck B (2003) Animal behavior models of the mechanisms underlying antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry 27: 1071–1079
Goff DC, Sullivan LM, McEvoy JP et al (2005) A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls. Schizophr Res 80: 45–53
Gründer G, Yokoi F, Offord SJ et al (1997) Time course of 5-HT2A receptor occupancy in the human brain after a single oral dose of the putative antipsychotic drug MDL 100,907 measured by positron emission tomography. Neuropsychopharmacology 17: 175–185
Gründer G, Wetzel H, Schlösser R et al (1999) Neuroendocrine response to antipsychotics: effects of drug type and gender. Biol Psychiatry 45: 89–97
Gründer G, Vernaleken I, Benkert O (2001) Welche Eigenschaften machen ein Neuropleptikum ≫atypisch≪? Nervenarzt 72: 833–843
Gründer G, Carlsson A, Wong DF (2003) Mechanism of new antipsychotic medications: occupancy is not just antagonism. Arch Gen Psychiatry 60: 974–977
Gründer G, Landvogt C, Vernaleken I et al (2006) The striatal and extrastriatal D2/D3 receptor binding profile of clozapine in patients with schizophrenia. Neuropsychopharmacology 31: 1027–1035
Guttmacher MS (1964) Phenothiazine treatment in acute schizophrenia; effectiveness: the National Institute of Mental Health Psychopharmacology Service Center Collaborative Study Group. Arch Gen Psychiatry 10: 246–261
Haase HJ (1961) Das therapeutische Achsensyndrome neuroleptischer Medikamente und seine Beziehungen zu extrapyramidaler Symptomatik. Fortschr Neurol Psychiatr 29: 245–268
Hiemke C, Dragicevic A, Gründer G, Härtter S, Sachse J, Vernaleken I, Müller MJ (2004) Therapeutic monitoring of new antipsychotic drugs. Ther Drug Monit 26: 156–160
Hiemke C, Baumann P, Laux G, Kuss H-J. (2005) Therapeutisches Drug-Monitoring in der Psychiatrie. Psychopharmakotherapie 12: 166–182
Hippius H (1999) A historical perspective of clozapine. J Clin Psychiatry 60(Suppl 12): 22–23
Hogarty GE, Goldberg SC (1973) Drug and sociotherapy in the after-care of schizophrenic patients. One-year relapse rates. Arch Gen Psychiatry 28: 54–64
Howes OD, Wheeler MJ, Meaney AM et al (2005) Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment. J Clin Psychopharmacol 25: 259–261
Ichlkawa J, Meltzer HY (1991) Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens. J Pharmacol Exp Ther 256: 348–357
Jeste DV, Lacro JP, Bailey A, Rockwell E, Harris MJ, Caligiuri MP (1999) Lower incidence of tardive dyskinesia with risperidone compared with haloperidol in older patients. J Am Gerlatr Soc 47: 716–719
Jones PB, Barnes TR, Davies L et al (2006) Randomized controlled trial of the effect on Quality of Life of second-vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Arch Gen Psychiatry 63: 1079–1087
Kane J, Honigfeld G, Singer J, Meltzer H (1988) Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psychiatry 45: 789–796
Kapur S, Zipursky RB, Remington G, Jones C, DaSilva J, Wilson AA, Houle S (1998) 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am J Psychiatry 155: 921–928
Keefe RS, Bilder RM, Davis SM et al: CATIE Investigators; Neurocognitive Working Group (2007) Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial. Arch Gen Psychiatry 64: 633–647
Kornhuber J, Schultz A, Wiltfang J et al (1999) Persistence of haloperidol in human brain tissue. Am J Psychiatry 156: 885–890
Kroeze WK, Hufeisen SJ, Popadak BA et al (2003) H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28: 519–526
Lane HY, Chang YC, Liu YC, Chlu CC, Tsai GE (2005) Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study. Arch Gen Psychiatry 62: 1196–1204
Li Z, Huang M, Ichikawa J, Dai J, Meltzer HY (2005) N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors. Neuropsychopharmacology 30: 1986–1995
Lieberman JA, Stroup TS, McEvoy JP et al; Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Investigators (2005a) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 353: 1209–1223
Lieberman JA, Tollefson GD, Charles C et al: HGDH Study Group (2005b) Antipsychotic drug effects on brain morphology in first-eplsode psychosis. Arch Gen Psychiatry 62: 361–370
McEvoy JP, Meyer JM, Goff DC et al (2005) Prevalence of the metabolic syndrome in patients with schizophrenia: baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III. Schizophr Res 80: 19–32
Meaney AM, Smith S, Howes OD, O’Brien M, Murray RM, O’Keane V (2004) Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia. Br J Psychiatry 184: 503–508
Meltzer HY, Matsubara S, Lee JC (1989) The ratios of serotonin 2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs. Psychopharmacol Bull 25: 390–392
Meltzer HY, Li Z, Kaneda Y, Ichikawa J (2003a) Serotonin receptors: their key role in drugs to treat schizophrenia. Progr Neuro-Psychopharmacol Biol Psychiatry 27: 1159–1172
Meltzer HY, Alphs L, Green AI et al.: International Suicide Prevention Trial Study Group (2003b) Clozapine treatment for suicidality in schizophrenia: International Suicide Prevention Trial (InterSePT). Arch Gen Psychiatry 60: 82–91
Moghaddam B (1994) Preferential activiation of cortical dopamine neurotransmission by clozapine: functional significance. J Clin Psychiatry 55(Suppl B): 27–29
Newcomer JW (2007) Metabolic considerations in the use of antipsychotic medications: a review of recent evidence. J Clin Psychiatry 68(Suppl 1): 20–27
Oosthuizen PP, Emsley RA, Maritz JS, Turner JA, Keyter N (2003) Incidence of tardive dyskinesia in first-episode psychosis patients treated with low-dose haloperidol. J Clin Psychiatry 64: 1075–1080.
Roth BL, Sheffler DJ, Kroeze WK (2004) Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature Rev Drug Discov 3: 353–359
Ray WA, Meredith S, Thapa PB, Meador KG, Hall K, Murray KT (2001) Antipsychotics and the risk of sudden cardiac death. Arch Gen Psychiatry 58: 1161–1167
Schooler NR, Kane JM (1982) Research diagnoses for tardive dyskinesia. Arch Gen Psychiatry 39: 486–487
Seeman P, Lee T, Chau-Wong M, Wong K (1976) Antipsychotic drug doses and neuroleptic/dopamine receptors. Nature 261(5562): 717–719
Seeman P, Schwarz J, Chen JF et al (2006) Psychosis pathways converge via D2High dopamine receptors. Synapse 60: 319–346
Shapiro DA, Renock S, Arrington E et al (2003) Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology 28: 1400–1411
Stille G, Hipplus H (1971) Kritische Stellungnahme zum Begriff der Neuroleptica (anhand von pharmakologischen und klinischen Befunden mit Clozapin). Pharmacopsychiatr Neuropsychopharmacol 4: 182–191
Stöllberger C, Huber JO, Finsterer J (2005) Antipsychotic drugs and QT prolongation. Int Clin Psychopharmacol 20: 243–251
Stroup TS, Alves WM, Hamer RM, Lieberman JA (2006) Clinical trials for antipsychotic drugs: design conventions, dilemmas and innovations. Nature Rev Drug Discov 5: 133–146
Stroup TS, Lieberman JA, McEvoy JP et al; CATIE Investigators (2007) Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study. Am J Psychiatry 164: 415–427
van Marum RJ, Wegewijs MA, Loonen AJ, Beers E (2007) Hypothermia following antipsychotic drug use. Eur J Clin Pharmacol 63: 627–631
Vernaleken I, Slessmeier T, Buchholz HG et al (2004) High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia. Int J Neuropsychopharmacol 7: 421–430
Wijkstra J, Lijmer J, Balk F, Geddes J, Nolen WA (2005) Pharmacological treatment for psychotic depression. Cochrane Database Syst Rev 19: CD004044
Wolkin A, Barouche F, Wolf AP et al (1989) Dopamine blockade and clinical response: evidence for two biological subgroups of schizophrenia. Am J Psychiatry 146: 905–908
Zimbroff DL, Kane JM, Tamminga CA et al (1997) Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group. Am J Psychiatry 154: 782–791
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
Gründer, G. (2008). Antipsychotika. In: Holsboer, F., Gründer, G., Benkert, O. (eds) Handbuch der Psychopharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68748-1_30
Download citation
DOI: https://doi.org/10.1007/978-3-540-68748-1_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20475-6
Online ISBN: 978-3-540-68748-1
eBook Packages: Medicine (German Language)