Family Iridoviridae: Poor Viral Relations No Longer

  • V. G. ChincharEmail author
  • A. Hyatt
  • T. Miyazaki
  • T. Williams
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 328)

Members of the family Iridoviridae infect a diverse array of invertebrate and cold-blooded vertebrate hosts and are currently viewed as emerging pathogens of fish and amphibians. Iridovirid replication is unique and involves both nuclear and cytoplasmic compartments, a circularly permuted, terminally redundant genome that, in the case of vertebrate iridoviruses, is also highly methylated, and the efficient shutoff of host macromolecular synthesis. Although initially neglected largely due to the perceived lack of health, environmental, and economic concerns, members of the genus Ranavirus, and the newly recognized genus Megalocytivirus, are rapidly attracting growing interest due to their involvement in amphibian population declines and their adverse impacts on aquaculture. Herein we describe the molecular and genetic basis of viral replication, pathogenesis, and immunity, and discuss viral ecology with reference to members from each of the invertebrate and vertebrate genera.


African Swine Fever Virus White Sturgeon Invertebr Pathol Iridescent Virus Chilo Iridescent Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • V. G. Chinchar
    • 1
    Email author
  • A. Hyatt
    • 2
  • T. Miyazaki
    • 3
  • T. Williams
    • 4
  1. 1.Department of MicrobiologyUniversity of Mississippi Medical CenterJacksonUSA
  2. 2.Australian Animal Health LaboratoryGeelongAustralia
  3. 3.Graduate School of BioresourcesMie UniversityMieJapan
  4. 4.Instituto de Ecologia ACXalapaMexico

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