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African Swine Fever Virus

  • E. R. TulmanEmail author
  • G. A. Delhon
  • B. K. Ku
  • D. L. Rock
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 328)

African swine fever virus (ASFV) is a large, intracytoplasmically-replicating DNA arbovirus and the sole member of the family Asfarviridae. It is the etiologic agent of a highly lethal hemorrhagic disease of domestic swine and therefore extensively studied to elucidate the structures, genes, and mechanisms affecting viral replication in the host, virus—host interactions, and viral virulence. Increasingly apparent is the complexity with which ASFV replicates and interacts with the host cell during infection. ASFV encodes novel genes involved in host immune response modulation, viral virulence for domestic swine, and in the ability of ASFV to replicate and spread in its tick vector. The unique nature of ASFV has contributed to a broader understanding of DNA virus/host interactions.

Keywords

African Swine Fever African Swine Fever Virus Domestic Swine Central Variable Region African Swine Fever Virus Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • E. R. Tulman
    • 1
    Email author
  • G. A. Delhon
    • 2
  • B. K. Ku
    • 3
  • D. L. Rock
    • 4
  1. 1.Department of Pathobiology and Veterinary Science, and Center of Excellence for Vaccine ResearchUniversity of ConnecticutStorrsUSA
  2. 2.Department of Pathobiology, College of Veterinary MedicineUniversity of IllinoisUrbanaUSA
  3. 3.National Veterinary Research and Quarantine ServiceKorea
  4. 4.Department of PathobiologyCollege of Veterinary Medicine, University of IllinoisUrbanaUSA

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