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Pathophysiology and Aging of Bone

  • Chapter
Radiology of Osteoporosis

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Human aging is a complex process which, as a result of multiple genetically programmed mechanisms as well as stochastic events, leads to accumulation of damaging alterations in vital cellular functions. A variety of in vitro studies indicate that aging is associated with an overall decline in protein synthesis and protein turnover as well as with an accumulation of damaged molecules (Glowacki 1999). With respect to bone turnover, several authors investigated the effects of age on generation, maturation, and function of osteoblasts in experimental animals as well as in humans. In rats, for example, a defect in maturation of preosteoblasts into osteoblasts was demonstrated, which led to a more than ten-fold decrease in the number of osteoblasts with age (Roholl et al. 1994). Quarto et al. (1995) determined the number of osteoprogenitor cells in bone marrow from adult and aged rats as well as their ability to differentiate and form bone. The number of adherent colony forming cells was significantly lower in marrow cells from aged rats than in those from adult rats.

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  1. Department of Pathophysiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Peter Pietschmann MD (Associate Professor of Pathophysiology and Internal Medicine) & Meinrad Peterlik PhD, MD (Professor and Head)

  2. Ludwig Boltzmann Institute of Aging Research, Langobardenstrasse 122, 1220, Vienna, Austria

    Peter Pietschmann MD (Associate Professor of Pathophysiology and Internal Medicine)

  3. Department of Oral Surgery, Vienna University Clinic of Dentistry, Medical University of Vienna, Waehringer Strasse 25a, 1090, Vienna, Austria

    Reinhard Gruber PhD (Associate Professor)

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  1. Peter Pietschmann MD
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  1. Dr. Grampp & Dr. Henk OEG Röntgenordination, Univ. Dozent, Lenaustrasse 23, 2000, Stockerau, Austria

    Stephan Grampp MD

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Pietschmann, P., Gruber, R., Peterlik, M. (2008). Pathophysiology and Aging of Bone. In: Grampp, S. (eds) Radiology of Osteoporosis. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68604-0_2

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