Zusammenfassung
Obwohl funktionelle Asymmetrien des Gehirns bereits in der Mitte des 19. Jahrhunderts beschrieben wurden, verstehen wir die Ursachen und Mechanismen der Hemisphärenspezialisierung (Lateralisierung) bisher nur unzureichend. Dieses Kapitel gibt einen Überblick, wie Fragen der Lateralisierung mit Hilfe der fMRT untersucht werden können und welche Vorteile die fMRT gegenüber anderen Verfahren bietet. Des Weiteren ist Hemisphärenspezialisierung eng mit Fragen zur Konnektivität des Hirns verzahnt. Zum einen wäre die Lateralisierung von Funktionen nutzlos ohne die Möglichkeit, die Funktion beider Hemisphären zu integrieren; zum anderen gibt es eine zunehmende Zahl von Befunden, die die Natur der funktionellen Hemisphätenunterschiede über Konnektivitätsunterschiede beschreiben. Aus diesen Gründen werden Lateralisierung und Konnektivität in diesem Kapitel zusammen behandelt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
22.5 Literatur
Amunts K, Zilles K (2001) Advances in cytoarchitectonic mapping of the human cerebral cortex. Neuroimag Clin N Am 11:151–169
Binder JR, Frost JA, Hammeke TA, Bellgowan PSF, Springer JA, Kaufman JN, Possing ET (2000) Human temporal lobe activation by speech and non-speech sounds. Cereb Cortex 10:512–528
Bokde AL, Tagamets MA, Friedman RB, Horwitz B (2001) Functional interactions of the inferior frontal cortex during the processing of words and word-like stimuli. Neuron 30:609–617
Bookheimer S (2002) Functional MRI of language: new approaches to understanding the cortical organization of semantic processing. Annu Rev Neurosci 25:151–188
Bradshaw JL, Nettleton NC (1981) The nature of hemispheric specialization in man. Behav Brain Sci 4:51–63
Büchel C, Friston KJ (1997) Modulation of connectivity in visual pathways by attention: cortical interactions evaluated with structural equation modelling and fMRI. Cereb Cortex 7:768–778
Büchel C, Raedler T, Sommer M, Sach M, Weiller C, Koch MA (2004) White matter asymmetry in the human brain: a diffusion tensor MRI study. Cereb Cortex 14:945–951
Bullmore E, Horwitz B, Honey G, Brammer M, Williams S, Sharma T (2000) How good is good enough in path analysis of fMRI data? NeuroImage 11:289–301
Burns J, Job D, Bastin ME, Whalley H, Macgillivray T, Johnstone EC, Lawrie SM (2003) Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. Br J Psychiatry 182:439–443
Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci 3:201–215
Corbetta M, Kincade JM, Ollinger JM, McAvoy MP, Shulman GL (2000) Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nat Neurosci 3:292–297
Fink GR, Halligan PW, Marshall JC, Frith CD, Frackowiak RS, Dolan RJ (1996) Where in the brain does visual attention select the forest and the trees? Nature 382:626–628
Fink GR, Marshall JC, Shah NJ, Weiss PH, Halligan PW, Grosse-Ruyken M, Ziemons K, Zilles K, Freund HJ (2000) Line bisection judgments implicate right parietal cortex and cerebellum as assessed by fMRI. Neurology 54:1324–1331
Fink GR, Marshall JC, Weiss PH, Zilles K (2001) The neural basis of vertical and horizontal line bisection judgments: an fMRI study of normal volunteers. NeuroImage 14:S59–67
Fink GR, Marshall JC, Weiss PH, Toni I, Zilles K (2002) Task instructions influence the cognitive strategies involved in line bisection judgements: evidence from modulated neural mechanisms revealed by fMRI. Neuropsychologia 40:119–130
Friston KJ (1995) Functional and effective connectivity in neuroimaging: a synthesis. Hum Brain Mapp 2:56–78
Friston KJ, Büchel C, Fink GR, Morris J, Rolls E, Dolan RJ (1997) Psychophysiological and modulatory interactions in neuroimaging. NeuroImage 6:218–229
Friston KJ, Harrison L, Penny W (2003) Dynamic causal modelling. NeuroImage 19:1273–1302
Frost JA, Binder JR, Springer JA, Hammeke TA, Bellgowan PS, Rao SM, Cox RW (1999) Language processing is strongly left lateralized in both sexes. Evidence from functional MRI. Brain 122:199–208
Gazzaniga M (2000) Cerebral specialization and interhemispheric communication. Brain 123:1293–1326
Galuske RA, Schlote W, Bratzke H, Singer W (2000) Interhemispheric asymmetries of the modular structure in human temporal cortex. Science 289:1946–1949
Gitelman DR, Nobre AC, Parrish TB, LaBar KS, Kim YH, Meyer JR, Mesulam M (1999) A large-scale distributed network for covert spatial attention: further anatomical delineation based on stringent behavioural and cognitive controls. Brain 122:1093–1106
Gitelman DR, Parrish TB, Friston KJ, Mesulam MM (2002) Functional anatomy of visual search: regional segregations within the frontal eye fields and effective connectivity of the superior colliculus. NeuroImage 15:970–982
Halligan PW, Fink GR, Marshall JC, Vallar G (2003) Spatial cognition: evidence from visual neglect. Trends Cogn Sci 7:125–133
Hellige JB (1990) Hemispheric asymmetry. Annu Rev Psychol 41:55–80
Hopfinger JB, Buonocore MH, Mangun GR (2000) The neural mechanisms of top-down attentional control. Nat Neurosci 3:284–291
Hulshoff Pol HE, Schnack HG, Mandl RC, Cahn W, Collins DL, Evans AC, Kahn RS (2003) Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity. NeuroImage 21:27–35
Irwin W, Anderle MJ, Abercrombie HC, Schaefer SM, Kalin NH, Davidson RJ (2004) Amygdalar interhemispheric functional connectivity differs between the non-depressed and depressed human brain. NeuroImage 21:674–686
Jenner AR, Rosen GD, Galaburda AM (1999) Neuronal asymmetries in primary visual cortex of dyslexic and nondyslexic brains. Ann Neurol 46:189–196
Klingberg T, Hedehus M, Temple E, Salz T, Gabrieli JDE, Moseley ME, Poldrack RA (2000) Microstructure of temporo-tarietal white matter as a basis for reading ability: Evidence from diffusion tensor magnetic resonance imaging. Neuron 25:493–500
Knecht S, Floel A, Drager B, Breitenstein C, Sommer J, Henningsen H, Ringelstein EB, Pascual-Leone A (2002) Degree of language lateralization determines susceptibility to unilateral brain lesions. Nat Neurosci 5:695–699
Manjaly ZM, Marshall JC, Stephan KE, Gurd JM, Zilles K, Fink GR (2003) In search of the hidden: an fMRI study with implications for the study of patients with autism and with acquired brain injury. NeuroImage 19:674–683
Marshall JC, Fink GR (2001) Spatial cognition: where we were and where we are. NeuroImage 14:S2–7
Mort DJ, Malhotra P, Mannan SK, Rorden C, Pambakian A, Kennard C, Husain M (2003) The anatomy of visual neglect. Brain 126:1986–1997
McGuire PK, Bates JF, Goldman-Rakic PS (1991) Interhemispheric integration: I. Symmetry and convergence of the corticocortical connections of the left and the right principal sulcus (PS) and the left and the right supplementary motor area (SMA) in the rhesus monkey. Cereb. Cortex 1:390–407
McIntosh AR, Grady CL, Ungerleider LG, Haxby JV, Rapoport SI, Horwitz B (1994) Network analysis of cortical visual pathways mapped with PET. J Neurosci 14:655–666
Levy J, Trevarthen C (1976) Metacontrol of hemispheric function in human split-brain patients. J Exp Psychol Hum Percept Perform 2:299–312
Parker GJ, Stephan KE, Barker GJ, Rowe JB, MacManus DG, Wheeler-Kingshott CA, Ciccarelli O, Passingham RE, Spinks RL, Lemon RN, Turner R (2002) Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography. NeuroImage 15:797–809
Parker GJ, Haroon HA, Wheeler-Kingshott CA (2003) A framework for a streamline-based probabilistic index of connectivity (PICo) using a structural interpretation of MRI diffusion measurements. J Magn Reson Imaging 18:242–254
Petersen SE, Fox PT, Snyder AZ, Raichle ME (1990) Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli. Science 249:1041–1044
Poldrack RA, Wagner AD, Prull MW, Desmond JE, Glover GH, Gabrieli JD (1999) Functional specialization for semantic and phonological processing in the left inferior prefrontal cortex. NeuroImage 10:15–35
Posner MI, Walker JA, Friedrich FJ, Rafal RD (1984) Effects of parietal injury on covert orienting of attention. J Neurosci 4:1863–1874
Price CJ, Wise RJ, Frackowiak RS (1996) Demonstrating the implicit processing of visually presented words and pseudowords. Cereb Cortex 6:62–70
Pugh KR, Shaywitz BA, Shaywitz SE, Constable RT, Skudlarski P, Fulbright RK, Byrd D, Shankweiler DP, Katz L, Fletcher J, Lacadie C, Marchione K, Gore JC (1996) Cerebral organization of component processes in reading. Brain 119:1221–1138
Schlösser R, Gesierich T, Kaufmann B, Vucurevic G, Hunsche S, Gawehn J, Stoeter P (2003) Altered effective connectivity during working memory performance in schizophrenia: a study with fMRI and structural equation modeling. NeuroImage 19:751–763
Sergent J (1983) Role of the input in visual hemispheric asymmetries. Psychol Bull 93:481–512
Small SL, Burton MW (2001) Functional neuroimaging of language. In: Berndt RS (ed) Handbook of neuropsychology. Elsevier, New York, pp 335–351
Sommer M, Koch MA, Paulus W, Weiller C, Buchel C (2002) Disconnection of speech-relevant brain areas in persistent developmental stuttering. Lancet 360:380–383
Spencer KM, Nestor PG, Niznikiewicz MA, Salisbury DF, Shenton ME, McCarley RW (2003) Abnormal neural synchrony in schizophrenia. J Neurosci 23:7407–7411
Stephan KE, Kamper L, Bozkurt A, Burns GA, Young MP, Kotter R (2001) Advanced database methodology for the collation of connectivity data on the macaque brain (CoCoMac). Philos Trans R Soc Lond B Biol Sci 356:1159–1186
Stephan KE, Marshall JC, Friston KJ, Rowe JB, Ritzl A, Zilles K, Fink GR (2003) Lateralized cognitive processes and lateralized task control in the human brain. Science 301:384–386
Stephan KE, Penny WD, Marshall JC, Fink GR, Friston KJ (2005) Investigating the functional role of callosal connections with dynamic causal models. Ann NY Acad Sci 1064:16–36
Tagamets MA, Novick JM, Chalmers ML, Friedman RB (2000) A parametric approach to orthographic processing in the brain: an fMRI study. J Cogn Neurosci 12:281–297
Tamura M, Hoshi Y, Okada F (1997) Localized near-infrared spectroscopy and functional optical imaging of brain activity. Philos Trans R Soc Lond B Biol Sci 352:737–742
Toosy AT, Ciccarelli O, Parker GJ, Wheeler-Kingshott CA, Miller DH, Thompson AJ (2004) Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging. NeuroImage 21:1452–1463
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
Stephan, K.E., Fink, G.R. (2007). Lateralität und Konnektivität. In: Schneider, F., Fink, G.R. (eds) Funktionelle MRT in Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68558-6_23
Download citation
DOI: https://doi.org/10.1007/978-3-540-68558-6_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20474-9
Online ISBN: 978-3-540-68558-6
eBook Packages: Medicine (German Language)