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Sepsis und Multiorganversagen

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NeuroIntensiv

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Sepsis, septischer Schock und sepsisinduziertes Multiorganversagen haben einen wesentlichen Anteil an der Mortalität von Patienten auf Intensivstationen [1, 70]. Trotz vieler Weiterentwicklungen auf dem Gebiet der Intensivmedizin hat sich die Letalität der Sepsis (35–70%) in den letzten Jahren nicht wesentlich geändert [98]. Die verschiedenen Aspekte der Pathophysiologie bei Sepsis sind Thema unzähliger Untersuchungen und Veröffentlichungen der letzten Jahre. Obwohl viele der so gewonnenen Erkenntnisse dazu beigetragen haben, das Krankheitsbild der Sepsis besser zu verstehen, haben nur wenige auch neue oder verbesserte Therapieansätze hervorgebracht. So sind das Zusammenspiel und die Bedeutung der verschiedenen Mediatoren des inflammatorischen Systems heute besser bekannt. Wesentliche therapeutische Optionen haben sich daraus bisher aber nicht ergeben. Ein wichtiger Bestandteil der Therapie bei Sepsis und Multiorganversagen ist daher nach wie vor eine adäquate und differenzierte Kreislauftherapie.

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  1. Klinik für Anästhesie, Intensivmedizin und Schmerztherapie, HELIOS Klinikum Erfurt GmbH, Nordhäuser Str. 74, 99089, Erfurt

    Prof. Dr. A. Meier-Hellmann

  2. Klinik für Anästhesie, Intensivmedizin, Intensivtherapie und Schmerztherapie, HELIOS Klinikum Erfurt GmbH, Nordhäuser Str. 74, 99089, Erfurt

    Dr. G. Burgard

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  1. Neurologische Klinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen

    Stefan Schwab  & Peter Schellinger  & 

  2. Klinik für Anästhesiologie, Klinikum der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz

    Christian Werner

  3. Neurochirurgische Klinik, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg

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Meier-Hellmann, A., Burgard, G. (2008). Sepsis und Multiorganversagen. In: Schwab, S., Schellinger, P., Werner, C., Unterberg, A., Hacke, W. (eds) NeuroIntensiv. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68317-9_19

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