Abstract
In most patients suffering from cancer, the primary tumor can be resected in a curative intention. However, during patient’s history, liver metastases occur — depending on the tumor — in up to 70%. There are data from large autopsy studies showing that liver metastases are detectable in more than 40% of all malignancies (Tranberg 2004). Liver metastases therefore have the highest impact on patient’s long-term survival and are responsible for the largest part of cancer-related deaths worldwide (Tranberg 2004). In the western world metastases of colorectal cancer are the most common indication for resection, followed by metastases of breast cancer. It has been shown that the 3-, 5-, and 10-year survival rates after a successful resection of liver metastases are as high as 45%, 30%, and 20% respectively (Ohlsson et al. 1998; Scheele et al. 1995). For this reason, in recent years surgical resection was considered to be the only curative option in liver metastases, while chemotherapy and radiation therapy were viewed as only palliative treatment options.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson GS, Brinkmann F, Soulen MC et al (2003) FDG positron emission tomography in the surveillance of hepatic tumors treated with radiofrequency ablation. Clin Nucl Med 28:192–197
de Baere T, Elias D, Dromain C et al (2000) Radiofrequency ablation of 100 hepatic metastases with a mean follow-up of more than 1 year. AJR Am J Roentgenol 175:1619–1625
Bilchik AJ, Wood TF, Allegra DP (2001) Radiofrequency ablation of unresectable hepatic malignancies: lessons learned. Oncologist 6:24–33
Cioni D, Lencioni R, Bartolozzi C (2001) Percutaneous ablation of liver malignancies: imaging evaluation of treatment response. Eur J Ultrasound 13:73–93
Curley SA (2003) Radiofrequency ablation of malignant liver tumors. Ann Surg Oncol 10:338–347
Curley SA, Izzo F, Delrio P et al (1999) Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients. Ann Surg 230:1–8
Curley SA, Izzo F, Ellis LM et al (2000) Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann Surg 232:381–391
Curley SA, Marra P, Beaty K et al (2004) Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Ann Surg 239:450–458
Donckier V, Van Laethem JL, Goldman S et al (2003) [F-18] fluorodeoxyglucose positron emission tomography as a tool for early recognition of incomplete tumor destruction after radiofrequency ablation for liver metastases. J Surg Oncol 84:215–223
Erce C, Parks RW (2003) Interstitial ablative techniques for hepatic tumours. Br J Surg 90:272–289
Gazelle GS, Goldberg SN, Solbiati L et al (2000) Tumor ablation with radio-frequency energy. Radiology 217:633–646
Gillams AR, Lees WR (2004) Radio-frequency ablation of colorectal liver metastases in 167 patients. Eur Radiol 14:2261–2267
Goldberg SN, Ahmed M (2002) Minimally invasive image-guided therapies for hepatocellular carcinoma. J Clin Gastroenterol 35:S115–S129
Joosten J, Jager G, Oyen W, Wobbes T, Ruers T (2005) Cryosurgery and radiofrequency ablation for unresectable colorectal liver metastases. Eur J Surg Oncol 31:1152–1159
Lencioni R, Cioni D, Bartolozzi C (2001) Percutaneous radiofrequency thermal ablation of liver malignancies: techniques, indications, imaging findings, and clinical results. Abdom Imaging 26:345–360
Lencioni R, Cioni D, Crocetti L et al (2002) Ultrasound imaging of focal liver lesions with a second-generation contrast agent. Acad Radiol 9[Suppl 2]:S371–374
Liu LX, Jiang HC, Piao DX (2002) Radiofrequency ablation of liver cancers. World J Gastroenterol 8:393–399
Livraghi T, Meloni F (2001) Removal of liver tumours using radiofrequency waves. Ann Chir Gynaecol 90:239–245
Livraghi T, Solbiati L, Meloni MF et al (2003) Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology 226:441–451
McGahan JP, Browning PD, Brock JM et al (1990) Hepatic ablation using radiofrequency electrocautery. Invest Radiol 25:267–270
Mulier S, Mulier P, Ni Y et al (2002) Complications of radiofrequency coagulation of liver tumours. Br J Surg 89:1206–1222
Ohlsson B, Stenram U, Tranberg KG (1998) Resection of colorectal liver metastases: 25-year experience. World J Surg 22:268–276; discussion 276–267
Pereira PL, Trubenbach J, Schmidt D (2003) Radiofrequency ablation: basic principles, techniques and challenges. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 175:20–27
Rossi S, Fornari F, Pathies C et al (1990) Thermal lesions induced by 480 kHz localized current field in guinea pig and pig liver. Tumori 76:54–57
Scheele J, Stang R, Altendorf-Hofmann A et al (1995) Resection of colorectal liver metastases. World J Surg 19:59–71
Siperstein AE, Berber E (2001) Cryoablation, percutaneous alcohol injection, and radiofrequency ablation for treatment of neuroendocrine liver metastases. World J Surg 25:693–696
Solbiati L, Ierace T, Tonolini M et al (2001) Radiofrequency thermal ablation of hepatic metastases. Eur J Ultrasound 13:149–158
Tranberg KG (2004) Percutaneous ablation of liver tumours. Best Pract Res Clin Gastroenterol 18:125–145
Wood TF, Rose DM, Chung M et al (2000) Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann Surg Oncol 7:593–600
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Hoffmann, RT., Jakobs, T.F., Helmberger, T.K., Reiser, M.F. (2008). Radiofrequency Ablation (RFA). In: Vogl, T.J., Helmberger, T.K., Mack, M.G., Reiser, M.F. (eds) Percutaneous Tumor Ablation in Medical Radiology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68250-9_16
Download citation
DOI: https://doi.org/10.1007/978-3-540-68250-9_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-22518-8
Online ISBN: 978-3-540-68250-9
eBook Packages: MedicineMedicine (R0)