Anatomy and Physiology of the Nasolacrimal Ducts


1.4 Conclusions

The human efferent tear ducts are part of the lacrimal system. They consist of the upper and the lower lacrimal canaliculus, the lacrimal sac, and the nasolacrimal duct. As a draining and secretory system, the nasolacrimal ducts play a decisive role in tear transport and nonspecific immune defense. In this context the integrity of the mucosa as source of mucins and trefoil factor family peptides is of great importance with regard to tear drainage. Moreover, components of tear fluid are absorbed by the epithelium of the nasolacrimal passage and are transported into a surrounding vascular system. This system is comparable to a cavernous body that is subject to autonomic control and regulates tear outflow. Tear duct-associated lymphoid tissue (TALT) is present in the efferent tear ducts, displaying the cytomorphological and immunophenotypic features of mucosa-associated lymphoid tissue (MALT).


Ocular Surface Lacrimal Gland Nasolacrimal Duct Meibomian Gland Lacrimal Duct 
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  1. 1.
    Akiyama J, Hoffman A, Brown C, Allen L, Edmondson J, Poulain F, Hawgood S (2002) Tissue distribution of surfactant proteins A and D in the mouse. J Histochem Cytochem 50:993–996PubMedGoogle Scholar
  2. 2.
    Ayub M, Thale A, Hedderich J, Tillmann B, Paulsen F (2003) The cavernous body of the human efferent tear ducts functions in regulation of tear outflow. Invest Ophthalmol Vis Sci 44:4900–4907PubMedCrossRefGoogle Scholar
  3. 3.
    Belmonte C, Aracil A, Acosta C, Luna C, Gallar J (2004) Nerves and sensations from the eye surface. Ocular Surface 2:248–253PubMedGoogle Scholar
  4. 4.
    Gipson IK, Hori Y, Argüeso P (2004) Character of ocular surface mucins and their alteration in dry eye disease. Ocular Surface 2:131–148PubMedGoogle Scholar
  5. 5.
    Hoffmann W, Jagla W (2002) Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. Int Rev Cytol 213:147–181PubMedCrossRefGoogle Scholar
  6. 6.
    Langer G, Jagla W, Behrens-Baumann W, Walter S, Hoffmann W (1999) Secretory peptides TFF1 and TFF3 synthesized in human conjunctival goblet cells. Invest Ophthalmol Vis Sci 40:2220–2224PubMedGoogle Scholar
  7. 7.
    McCulley JP, Shine WE (2003) Meibomian gland function and the tear lipid layer. Ocular Surface 1:97–106PubMedGoogle Scholar
  8. 8.
    McDermott (2004) Defensins and other antimicrobial peptides at the ocular surface. Ocular Surface 2:229–247PubMedGoogle Scholar
  9. 9.
    Paulsen F (2003) The nasolacrimal ducts. Adv Anat Embryol Cell Biol 170:1–106Google Scholar
  10. 10.
    Paulsen F, Berry M (2006) Mucins and TFF peptides of the tear film and lacrimal apparatus. Progr Histochem Cytochem 41:1–56CrossRefGoogle Scholar
  11. 11.
    Paulsen F, Corfield A, Hinz M, Hoffmann W, Schaudig U, Thale A, Berry M (2003) Characterization of mucins in human lacrimal sac and nasolacrimal duct. Invest Ophthalmol Vis Sci 44:1807–1813PubMedCrossRefGoogle Scholar
  12. 12.
    Paulsen F, Corfield A, Hinz M, Hoffmann W, Schaudig U, Thale A, Berry M (2004) Tränenabfluss — Bedeutung von Muzinen und TFF-Peptiden. Ophthalmologe 101:19–24PubMedCrossRefGoogle Scholar
  13. 13.
    Paulsen F, Föge M, Thale A, Tillmann B, Mentlein R (2002) Absorption of lipophilic substances from tear fluid by the epithelium of the nasolacrimal ducts. Invest Ophthalmol Vis Sci 43:3137–3143PubMedGoogle Scholar
  14. 14.
    Paulsen F, Hallmann U, Paulsen J, Thale A (2000) Innervation of the cavernous body of the human efferent tear ducts and function in tear outflow mechanism. J Anat 197:373–381PubMedCrossRefGoogle Scholar
  15. 15.
    Paulsen F, Hinz M, Schaudig U, Thale AB, Hoffmann W (2002) TFF-peptides in the human efferent tear ducts. Invest Ophthalmol Vis Sci 43:3359–3364PubMedGoogle Scholar
  16. 16.
    Paulsen F, Langer G, Hoffmann W, Berry M (2004) Human lacrimal gland mucins. Cell Tissue Res 316:167–177PubMedCrossRefGoogle Scholar
  17. 17.
    Paulsen F, Paulsen J, Thale A, Tillmann B (2000) Mucosa-associated lymphoid tissue (MALT) in the human efferent tear ducts. Virchows Arch 437:185–189PubMedCrossRefGoogle Scholar
  18. 18.
    Paulsen F, Pufe T, Schaudig U, Held-Feindt J, Lehmann J, Schröder J-M, Tillmann B (2001) Detection of natural peptide antibiotics in human nasolacrimal ducts. Invest Ophthalmol Vis Sci 42:2157–2163PubMedGoogle Scholar
  19. 19.
    Paulsen F, Schaudig U, Thale A (2003) Drainage of tears: impact on the ocular surface and lacrimal system. Ocular Surface 1:180–191PubMedGoogle Scholar
  20. 20.
    Paulsen F, Thale A, Hallmann U, Schaudig U, Tillmann B (2000) The cavernous body of the human efferent tear ducts: function in tear outflow mechanism. Invest Ophthalmol Vis Sci 41:965–970PubMedGoogle Scholar
  21. 21.
    Paulsen F, Thale A, Kohla G, Schauer R, Rochels R, Parwaresch R, Tillmann B (1998) Functional anatomy of human duct epithelium. Anat Embryol 198:1–12PubMedCrossRefGoogle Scholar
  22. 22.
    Stern ME, Beuermann RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC (1998) The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584–589PubMedCrossRefGoogle Scholar
  23. 23.
    Stoeckelhuber M, Stoeckelhuber BM, Welsch U (2003) Human glands of Moll: histochemical and ultrastructural characterization of the glands of Moll in the human eyelid. J Invest Dermatol 121:28–36PubMedCrossRefGoogle Scholar
  24. 24.
    Sullivan DA, Sullivan BD, Ullman MD, Rocha EM, Krenzer KL, Cermak JM, Toda I, Doane MG, Evans JE, Wickham LA (2000) Androgen influence on the Meibomian gland. Invest Ophthalmol Vis Sci 41:3732–3742PubMedGoogle Scholar
  25. 25.
    Thale A, Paulsen F, Rochels R, Tillmann B (1998) Functional anatomy of human efferent tear ducts: a new theory of tear outflow. Graefe’s Arch Clin Exp Ophthalmol 236:674–678CrossRefGoogle Scholar
  26. 26.
    Tillmann B (2005) Atlas der Anatomie. Springer, Berlin Heidelberg, New YorkGoogle Scholar
  27. 27.
    Lüllmann Rauch R (2003) Histologie. Thieme, StuttgartGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.Department of Anatomy and Cell BiologyMartin Luther University of Halle-WittenbergHalle (Saale)Germany

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