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Integration of EEG and fMRI

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Neural Correlates of Thinking

Part of the book series: On Thinking ((ONTHINKING,volume 1))

Abstract

The integration of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has attracted a lot of interest in the last few years, offering insights into human brain function with both high temporal and high spatial information. Today, methodological problems of simultaneous measurements in terms of hardware and artifact correction are either being resolved or can be dealt with reasonably. While the combination of these two techniques had been of interest primarily in the clinical field of epilepsy, it is now increasingly gaining importance in the field of cognitive neuroscience, for example in offering information about mental chronometry aspects. This chapter describes relevant aspects such as the physiological principles, technical and methodological aspects, artifact correction and some interesting applications.

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References

  • Allen PJ, Polizzi G, Krakow K, Fish DR, Lemieux L (1998) Identification of EEG events in the MR scanner: the problem of pulse artifact and a method for its subtraction. Neuroimage 8:229–239

    Article  PubMed  CAS  Google Scholar 

  • Allen PJ, Josephs O, Turner R (2000) A method for removing imaging artifact from continuous EEG recorded during functional MRI. Neuroimage 12:230–239

    Article  PubMed  CAS  Google Scholar 

  • Anami K, Mori T, Tanaka F, Kawagoe Y, Okamoto J, Yarita M, Ohnishi T, Yumoto M, Matsuda H, Saitoh O (2003) Stepping stone sampling for retrieving artifact-free electroencephalogram during functional magnetic resonance imaging. Neuroimage 19:281–295

    Article  PubMed  Google Scholar 

  • Becker R, Ritter P, Moosmann M, Villringer A (2005) Visual evoked potentials recovered from fMRI scan periods. Hum Brain Mapp 26:221–230

    Article  PubMed  Google Scholar 

  • Benar CG, Schon D, Grimault S, Nazarian B, Bude B, Roth M, Badier JM, Marquis P, Liegeois-Chauvel C, Anton JL (2007) Single-trial analysis of oddball event-related potentials in simultaneous EEG-fMRI. Hum Brain Mapp 28:602–613

    Article  PubMed  Google Scholar 

  • Bledowski C, Prvulovic D, Hoechstetter K, Scherg M, Wibral M, Goebel R, Linden DE (2004) Localizing P300 generators in visual target and distractor processing: a combined event-related potential and functional magnetic resonance imaging study. J Neurosci 24:9353–9360

    Article  PubMed  CAS  Google Scholar 

  • Bonmassar G, Purdon PL, Jaaskelainen IP, Chiappa K, Solo V, Brown EN, Belliveau JW (2002) Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI. Neuroimage 16:1127–1141

    Article  PubMed  Google Scholar 

  • Callicott JH, Weinberger DR (1999) Neuropsychiatric dynamics: the study of mental illness using functional magnetic resonance imaging. Eur J Radiol 30:95–104

    Article  PubMed  CAS  Google Scholar 

  • Coltheart M (2006) What has functional neuroimaging told us about the mind (so far)? Cortex 42:323–331

    Article  PubMed  Google Scholar 

  • Czisch M, Wehrle R, Kaufmann C, Wetter TC, Holsboer F, Pollmacher T, Auer DP (2004) Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates. Eur J Neurosci 20:566–574

    Article  PubMed  Google Scholar 

  • Debener S, Ullsperger M, Siegel M, Fiehler K, von Cramon DY, Engel AK (2005) Trial-by-trial coupling of concurrent electroencephalogram and functional magnetic resonance imaging identifies the dynamics of performance monitoring. J Neurosci 25:11730–11737

    Article  PubMed  CAS  Google Scholar 

  • Debener S, Strobel A, Sorger B, Peters J, Kranczioch C, Engel AK, Goebel R (2007) Improved quality of auditory event-related potentials recorded simultaneously with 3-T fMRI: removal of the ballistocardiogram artefact. Neuroimage 34:587–597

    Article  PubMed  Google Scholar 

  • Durston S, Casey BJ (2006) What have we learned about cognitive development from neuroimaging? Neuropsychologia 44:2149–2157

    Article  PubMed  Google Scholar 

  • Eichele T, Specht K, Moosmann M, Jongsma ML, Quiroga RQ, Nordby H, Hugdahl K (2005) Assessing the spatiotemporal evolution of neuronal activation with single-trial event-related potentials and functional MRI. Proc Natl Acad Sci U S A 102:17798–17803

    Article  PubMed  CAS  Google Scholar 

  • Feige B, Scheffler K, Esposito F, Di Salle F, Hennig J, Scifritz E (2005) Cortical and subcortical correlates of electroencephalographic alpha rhythm modulation. J Neurophysiol 93:2864–2872

    Article  PubMed  Google Scholar 

  • Friston KJ, Harrison L, Penny W (2003) Dynamic causal modelling. Neuroimage 19:1273–1302

    Article  PubMed  CAS  Google Scholar 

  • Fukuda M, Moon CH, Wang P, Kim SG (2006) Mapping iso-orientation columns by contrast agent-enhanced functional magnetic resonance imaging: reproducibility, specificity, and evaluation by optical imaging of intrinsic signal. J Neurosci 26:11821–11832

    Article  PubMed  CAS  Google Scholar 

  • Gloveli T, Dugladze T, Saha S, Monyer H, Heinemann U, Traub RD, Whittington MA, Buhl EH (2005) Differential involvement of oriens/pyramidale interneurones in hippocampal network oscillations in vitro. J Physiol 562:131–147

    Article  PubMed  CAS  Google Scholar 

  • Goldman RI, Stern JM, Engel J Jr., Cohen MS (2000) Acquiring simultaneous EEG and functional MRI. Clin Neurophysiol 111:1974–1980

    Article  PubMed  CAS  Google Scholar 

  • Goldman RI, Stern JM, Engel J Jr., Cohen MS (2002). Simultaneous EEG and fMRI of the alpha rhythm. Neuroreport 13: 2487–2492

    Article  PubMed  Google Scholar 

  • Hamandi K, Salek-Haddadi A, Fish DR, Lemieux L (2004) EEG/functional MRI in epilepsy: the Queen Square experience. J Clin Neurophysiol 21:241–248

    Article  PubMed  Google Scholar 

  • Helmholtz H (1853) Ãœber einige Gesetze der Vertheilung elektrischer Ströme in körperlichen Leitern mit der Anwendung auf die thierisch-elektrischen Versuche. Ann Phys Chem 211–233, 289, 353–377

    Google Scholar 

  • Hoffmann A, Jager L, Werhahn KJ, Jaschke M, Noachtar S, Reiser M (2000) Electroencephalography during functional echo-planar imaging: detection of epileptic spikes using post-processing methods. Magn Reson Med 44:791–798

    Article  PubMed  CAS  Google Scholar 

  • Krakow K, Allen PJ, Lemieux L, Symms MR, Fish DR (2000a) Methodology: EEG-correlated fMRI. Adv Neurol 83:187–201

    PubMed  CAS  Google Scholar 

  • Krakow K, Allen PJ, Symms MR, Lemieux L, Josephs O, Fish DR (2000b) EEG recording during fMRI experiments: image quality. Hum Brain Mapp 10:10–15

    Article  PubMed  CAS  Google Scholar 

  • Laufs H, Kleinschmidt A, Beyerle A, Eger E, Salek-Haddadi A, Preibisch C, Krakow K (2003a) EEG-correlated fMRI of human alpha activity. Neuroimage 19:1463–1476

    Article  PubMed  CAS  Google Scholar 

  • Laufs H, Krakow K, Sterzer P, Eger E, Beyerle A, Salek-Haddadi A, Kleinschmidt A (2003b) Electroencephalographic signatures of attentional and cognitive default modes in spontaneous brain activity fluctuations at rest. Proc Natl Acad Sci U S A 100:11053–11058

    Article  PubMed  CAS  Google Scholar 

  • Laufs H, Holt JL, Elfont R, Krams M, Paul JS, Krakow K, Kleinschmidt A (2006) Where the BOLD signal goes when alpha EEG leaves. Neuroimage 31:1408–1418

    Article  PubMed  CAS  Google Scholar 

  • Lee L, Friston K, Horwitz B (2006) Large-scale neural models and dynamic causal modelling. Neuroimage 30:1243–1254

    Article  PubMed  Google Scholar 

  • Lemieux L, Allen PJ, Franconi F, Symms MR, Fish DR (1997) Recording of EEG during fMRI experiments: patient safety. Magn Reson Med 38:943–952

    Article  PubMed  CAS  Google Scholar 

  • Lemieux L, Krakow K, Fish DR (2001) Comparison of spike-triggered functional MRI BOLD activation and EEG dipole model localization. Neuroimage 14:1097–1104

    Article  PubMed  CAS  Google Scholar 

  • Linden D (2007) What, when, where in the Brain? Exploring mental chronometry with brain imaging and electrophysiology. Rev Neurosci 18:159–171

    PubMed  Google Scholar 

  • Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412:150–157

    Article  PubMed  CAS  Google Scholar 

  • Lopes da Silva F, van Rotterdam A (1993) Biophysical aspects of EEG and magnetoencephalogram generation. In: Niedermeyer E, Lopes da Silva F (eds) Electroencephalography. Williams & Wilkins, Baltimore, pp 78–91

    Google Scholar 

  • Mandelkow H, Haider P, Boesiger P, Brandeis D (2006) Synchronization facilitates removal of MRI artefacts from concurrent EEG recordings and increases usable bandwidth. Neuroimage 32:1120–1126

    Article  PubMed  CAS  Google Scholar 

  • Mantini D, Perrucci MG, Del Gratta C, Romani GL, Corbetta M (2007) Electrophysiological signatures of resting state networks in the human brain. Proc Natl Acad Sci U S A 104:13170–13175

    Article  PubMed  CAS  Google Scholar 

  • Mitterschiffthaler MT, Ettinger U, Mehta MA, Mataix-Cols D, Williams SC (2006) Applications of functional magnetic resonance imaging in psychiatry. J Magn Reson Imaging 23:851–861

    Article  PubMed  Google Scholar 

  • Montague PR, Berns GS, Cohen JD, McClure SM, Pagnoni G, Dhamala M, Wiest MC, Karpov I, King RD, Apple N, Fisher RE (2002) Hyperscanning: simultaneous fMRI during linked social interactions. Neuroimage 16:1159–1164

    Article  PubMed  Google Scholar 

  • Moosmann M, Ritter P, Krastel I, Brink A, Thees S, Blankenburg F, Taskin B, Obrig H, Villringer A (2003) Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy. Neuroimage 20:145–158

    Article  PubMed  Google Scholar 

  • Mulert C, Jager L, Pogarell O, Bussfeld P, Schmitt R, Juckel G, Hegerl U (2002) Simultaneous ERP and event-related fMRI: focus on the time course of brain activity in target detection. Methods Find Exp Clin Pharmacol 24(Suppl D):17–20

    PubMed  Google Scholar 

  • Mulert C, Jager L, Schmitt R, Bussfeld P, Pogarell O, Möller HJ, Juckel G, Hegerl U (2004) Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection. Neuroimage 22:83–94

    Article  PubMed  Google Scholar 

  • Mulert C, Jager L, Propp S, Karch S, Stormann S, Pogarell O, Möller HJ, Juckel G, Hegerl U (2005) Sound level dependence of the primary auditory cortex: simultaneous measurement with 61-channel EEG and fMRI. Neuroimage 28:49–58

    Article  PubMed  Google Scholar 

  • Mulert C, Hepp P, Karch S, Leicht G, Moller HJ, Hegerl U, Pogarell O (2006) Simultaneous measurement of 40 Hz electrical activity and the corresponding BOLD-signal: methodological issues. Neuroimage 3l (Suppl 1):S112

    Google Scholar 

  • Mulert C, Scifert C, Leicht G, Kirsch V, Ertl M, Karch S, Moosmann M, Lutz J, Möller HJ, Hegerl U, Pogarell O, Jäger L (2008) Single-trial coupling of EEG and fMRI reveals the involvement of early anterior cingulate cortex activation in effortful decision making. Neuroimage. Apr 29. [Epub ahead of print]

    Google Scholar 

  • Mullinger K, Debener S, Coxon R, Bowtell R (2008) Effects of simultaneous EEG recording on MRI data quality at 1.5, 3 and 7 tesla. Int J Psychophysiol 67:178–188

    Article  PubMed  Google Scholar 

  • Niazy RK, Beckmann CF, Iannetti GD, Brady JM, Smith SM (2005) Removal of FMRI environment artifacts from EEG data using optimal basis sets. Neuroimage 28:720–737

    Article  PubMed  CAS  Google Scholar 

  • Ogawa S, Lee TM, Kay AR, Tank DW (1990) Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 87:9868–9872

    Article  PubMed  CAS  Google Scholar 

  • Otzenberger H, Gounot D, Foucher JR (2005) P300 recordings during event-related fMRI: a feasibility study. Brain Res Cogn Brain Res 23:306–315

    Article  PubMed  CAS  Google Scholar 

  • Pike FG, Goddard RS, Suckling JM, Ganter P, Kasthuri N, Paulsen O (2000) Distinct frequency preferences of different types of rat hippocampal neurones in response to oscillatory input currents. J Physiol 529(l):205–213

    Article  PubMed  CAS  Google Scholar 

  • Rocca MA, Filippi M (2006) Functional MRI to study brain plasticity in clinical neurology. Neurol Sci 27(Suppl 1):S24–S26

    Article  PubMed  Google Scholar 

  • Salek-Haddadi A, Merschhemke M, Lemieux L, Fish DR (2002) Simultaneous EEG-correlated ictal fMRI. Neuroimage 16:32–40

    Article  PubMed  Google Scholar 

  • Sammer G, Blecker C, Gebhardt H, Bischoff M, Stark R, Morgen K, Vaitl D (2007) Relationship between regional hemodynamic activity and simultaneously recorded EEG-theta associated with mental arithmetic-induced workload. Hum Brain Mapp 28:793–803

    Article  PubMed  Google Scholar 

  • Sanfey AG, Rilling JK, Aronson JA, Nystrom LE, Cohen JD (2003) The neural basis of economic decision-making in the ultimatum game. Science 300:1755–1758

    Article  PubMed  CAS  Google Scholar 

  • Siniatchkin M, Moeller F, Jacobs J, Stephani U, Boor R, Wolff S, Jansen O, Siebner H, Scherg M (2007) Spatial filters and automated spike detection based on brain topographies improve sensitivity of EEG-fMRI studies in focal epilepsy. Neuroimage

    Google Scholar 

  • Traub RD, Pais I, Bibbig A, LeBeau FE, Buhl EH, Hormuzdi SG, Monyer H, Whittington MA (2003) Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations. Proc Natl Acad Sci USA 100:1370–1374

    Article  PubMed  CAS  Google Scholar 

  • Ugurbil K, Toth L, Kim DS (2003) How accurate is magnetic resonance imaging of brain function? Trends Neurosci 26:108–114

    Article  PubMed  CAS  Google Scholar 

  • Wehrle R, Kaufmann C, Wetter TC, Holsboer F, Auer DP, Pollmacher T, Czisch M (2007) Functional microstates within human REM sleep: first evidence from fMRI of a thalamocortical network specific for phasic REM periods. Eur J Neurosci 25:863–871

    Article  PubMed  Google Scholar 

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Mulert, C., Hegerl, U. (2009). Integration of EEG and fMRI. In: Kraft, E., Gulyás, B., Pöppel, E. (eds) Neural Correlates of Thinking. On Thinking, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68044-4_7

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