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α-N-Acetylgalactosaminide α-2,6-sialyltransferase

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Class 2 · Transferases VI

Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 33))

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References

  1. Sadler, J.E.; Rearick, J.I.; Hill, R.L.: Purification to homogeneity and enzymatic characterization of an α-N-acetylgalactosaminide α2→6 sialyltransferase from porcine submaxillary glands. J. Biol. Chem., 254, 5934–5941 (1979)

    PubMed  CAS  Google Scholar 

  2. Sherblom, A.P.; Bourassa, C.R.: Specificity of submaxillary gland sialyltransferases. Biochim. Biophys. Acta, 761, 94–102 (1983)

    PubMed  CAS  Google Scholar 

  3. Beyer, T.A.; Rearick, J.I.; Paulson, J.C.; Prieels, J.P.; Sadler, J.E.; Hill, R.L.: Biosynthesis of mammalian glycoproteins. Glycosylation pathways in the synthesis of the nonreducing terminal sequences. J. Biol. Chem., 254, 12531–12541 (1979)

    PubMed  CAS  Google Scholar 

  4. Bergh, M.L.E.; van den Eijnden, D.H.: Aglycon specificity of fetal calf liver and ovine and porcine submaxillary gland α-N-acetylgalactosaminide α2→6 sialyltransferase. Eur. J. Biochem., 136, 113–118 (1983)

    Article  PubMed  CAS  Google Scholar 

  5. Higa, H.H.; Paulson, J.C.: Sialylation of glycoprotein oligosaccharides with N-acetyl-, N-glycolyl-, and N-O-diacetylneuraminic acids. J. Biol. Chem., 260, 8838–8849 (1985)

    PubMed  CAS  Google Scholar 

  6. Bauvois, B.; Cacan, R.; Fournet, B.; Caen, J.; Montreuil, J.; Verbert, A.: Discrimination between activity of (α2–3)-sialyltransferase and (α2–6)-sialyltransferase in human platelets using p-nitrophenyl-β-D-galactoside as ac-ceptor. Eur. J. Biochem., 121, 567–572 (1982)

    Article  PubMed  CAS  Google Scholar 

  7. Sadler, J.E.; Rearick, J.I.; Paulson, J.C.; Hill, R.L.: Purification to homogeneity of a β-galactoside α2→3 sialyltransferase and partial purification of an α-N-acetylgalactosaminide α2→6 sialyltransferase from porcine submaxillary glands. J. Biol. Chem., 254, 4434–4443 (1979)

    PubMed  CAS  Google Scholar 

  8. Gasnier, F.; Baubichon-Cortay, H.; Louisot, P.; Gateau-Roesch, O.: Sialylation processes in mitochondria: evidence for two distinct sialyltransferases located in the outer membrane. J. Biochem., 110, 702–707 (1991)

    PubMed  CAS  Google Scholar 

  9. Bergh, M.L.E.; Koppen, PL.; Van den Eijnden, D.H.: Specificity of ovine submaxillary-gland sialyltransferases. Application of high-pressure liquid chromatography in the identification of sialo-oligosaccharide products. Biochem. J., 201, 411–415 (1982)

    PubMed  CAS  Google Scholar 

  10. Gross, H.J.; Rose, U.; Krause, J.M.; Paulson, J.C.; Schmid, K.; Feeney, R.E.; Brossmer, R.: Transfer of synthetic sialic acid analogues to N-and O-linked glycoprotein glycans using four different mammalian sialyltransferases. Biochemistry, 28, 7386–7392 (1989)

    Article  PubMed  CAS  Google Scholar 

  11. Carlson, D.M.; McGuire, E.J.; Jourdian, G.W.; Roseman, S.: The sialic acids. XVI. Isolation of a mucin sialyltransferase from sheep submaxillary gland. J. Biol. Chem., 248, 5763–5773 (1973)

    PubMed  CAS  Google Scholar 

  12. Kitazume, S.; Kitajima, K.; Inoue, S.; Inoue, Y.; Troy, F.A., II: Developmental expression of trout egg polysialoglycoproteins and the prerequisite α2,6-, and α2,8-sialyl and α2,8-polysialyltransferase activities required for their synthesis during oogenesis. J. Biol. Chem., 269, 10330–10340 (1994)

    PubMed  CAS  Google Scholar 

  13. Schneider, F.; Kemmner, W.; Haensch, W.; Franke, G.; Gretschel, S.; Karsten, U.; Schlag, P.M.: Overexpression of sialyltransferase CMP-sialic acid:-Galβ1,3GalNAc-R α6-sialyltransferase is related to poor patient survival in human colorectal carcinomas. Cancer Res., 61, 4605–4611 (2001)

    PubMed  CAS  Google Scholar 

  14. Sotiropoulou, G.; Kono, M.; Anisowicz, A.; Stenman, G.; Tsuji, S.; Sager, R.: Identification and functional characterization of a human GalNAc α2,6-sialyltransferase with altered expression in breast cancer. Mol. Med., 8, 42–55 (2002)

    PubMed  CAS  Google Scholar 

  15. Julien, S.; Krzewinski-Recchi, M.A.; Harduin-Lepers, A.; Gouyer, V; Huet, G.; Le Bourhis, X.; Delannoy, P.: Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac:GalNAc α2,6-sialyltransferase (ST6GalNac I) cDNA. Glycoconjugate J., 18, 883–893 (2001)

    Article  CAS  Google Scholar 

  16. Marcos, N.T.; Cruz, A.; Silva, F.; Almeida, R.; David, L.; Mandel, U.; Clausen, H.; von Mensdorff-Pouilly, S.; Reis, C.A.: Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines. J. Histochem. Cytochem., 51, 761–771 (2003)

    PubMed  CAS  Google Scholar 

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(2007). α-N-Acetylgalactosaminide α-2,6-sialyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Class 2 · Transferases VI. Springer Handbook of Enzymes, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49753-0_43

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