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Matrix Metalloproteinases in Acute Lung Injury

  • Conference paper
Intensive Care Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2007))

Abstract

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases belonging to the metzincin superfamily of metalloproteinases. MMPs can degrade most of the components of the extracellular matrix and basement membrane. In addition, these enzymes can cleave some inflammatory mediators. This variety of substrates gives MMPs a wide number of functions during physiologic and pathologic processes. In this sense, many of the MMPs are not expressed in normal tissues, but expression and activity increases dramatically during matrix turnover, inflammation and repair.

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Author information

Authors and Affiliations

  1. Department of Intensive Care, University Hospital Central de Asturias, Celestino Villamil s/n, 33006, Oviedo, Spain

    G. M. Albaiceta

  2. Department of Functional Biology Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain

    A. Fueyo

Authors
  1. G. M. Albaiceta
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  2. A. Fueyo
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© 2007 Springer Science + Business Media Inc.

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Albaiceta, G.M., Fueyo, A. (2007). Matrix Metalloproteinases in Acute Lung Injury. In: Intensive Care Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49433-1_26

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  • DOI: https://doi.org/10.1007/978-3-540-49433-1_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-49432-4

  • Online ISBN: 978-3-540-49433-1

  • eBook Packages: MedicineMedicine (R0)

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