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Prevention and Treatment of Radiation Injuries

The Role of the Renin-Angiotensin System

  • Chapter
Book cover Late Effects of Cancer Treatment on Normal Tissues

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The renin-angiotensin system, local or systemic, plays a key role in normal tissue radiation injury. Angiotensin converting enzyme (ACE) inhibitors, which act to attenuate the conversion of angiotensin I to angiotensin II, are beneficial in mitigating experimental renal, lung, or brain normal tissue radiation injury. The benefit of ACE inhibitors and angiotensin II blockers has been particularly well documented in experimental radiation nephropathy, for either mitigation or treatment. The mechanism for this benefit remains incompletely understood. In particular, control of hypertension, proteinuria, or radiation-induced cell proliferation alone does not appear to determine the benefit of ACE inhibitors or angiotensin II blockers. Nonetheless, the significant experimental benefit of those agents fully justifies their use in human radiation nephropathy. Clinical trials using ACE inhibitors are underway in subjects undergoing radiation-based bone marrow transplantation and also in subjects undergoing curative radiotherapy for lung cancer.

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Author information

Authors and Affiliations

  1. Department of Medicine, Nephrology Division, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI, 53226, USA

    Eric P. Cohen MD

  2. Department of Medicine and Radiation Oncology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI, 53226, USA

    Melissa M. Joines BS

  3. Center for Medical Countermeasures Against Radialogicol Terrorism, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA

    John E. Moulder PhD (Professor of Radiation Oncology, Director)

Authors
  1. Eric P. Cohen MD
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  2. Melissa M. Joines BS
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  3. John E. Moulder PhD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Philip Rubin MD (Professor Emeritus, Chair Emeritus) & Paul Okunieff MD (Philip Rubin Professor of Radiation Oncology, Chair) (Professor Emeritus, Chair Emeritus) &  (Philip Rubin Professor of Radiation Oncology, Chair)

  2. Department of Radiation Oncology, Departments of Radiation Oncology and Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Louis S. Constine MD (Professor of Radiation Oncology and Pediatrics, Vice Chair) (Professor of Radiation Oncology and Pediatrics, Vice Chair)

  3. Department of Radiation Oncology, Duke University Medical Center, P.O. Box 3085, Durham, NC, 27710, USA

    Lawrence B. Marks MD (Professor) (Professor)

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© 2008 Springer-Verlag Berlin Heidelberg

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Cohen, E.P., Joines, M.M., Moulder, J.E. (2008). Prevention and Treatment of Radiation Injuries. In: Rubin, P., Constine, L.S., Marks, L.B., Okunieff, P. (eds) Late Effects of Cancer Treatment on Normal Tissues. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49070-8_9

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  • DOI: https://doi.org/10.1007/978-3-540-49070-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-49069-2

  • Online ISBN: 978-3-540-49070-8

  • eBook Packages: MedicineMedicine (R0)

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