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Late Effects of Cancer Treatment on Normal Tissues pp 23–30Cite as

Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury

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Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Radiation therapy is an effective means of killing tumor cells, although this effectiveness is tempered by limitations of the normal tissue to the adverse effects of radiation. An excellent example of this is radiation treatment for thoracic tumors, in particular, lung cancers. Despite advances in the technical delivery of radiation by three-dimensional (3D) planning via computed tomography (CT), radiation-induced injury to normal lung tissue still occurs in a large proportion of treated patients. The primary endpoints for radiation-induced pulmonary toxicity include early onset pneumonitis and late onset fibrosis. A significant amount of research has produced some insight into the mechanism(s) behind this injury. This knowledge has provided potential targets for drug development that could improve the therapeutic ratio for radiation by reducing both early and late toxicity. In this article, we review and update the pathologic mechanisms underlying radiation-induced lung injury as well as potential treatments, with particular interest in cell adhesion molecules and inflammation.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, The Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

    Christopher D. Willey MD, PhD & Dennis E. Hallahan MD

Authors
  1. Christopher D. Willey MD, PhD
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  2. Dennis E. Hallahan MD
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Philip Rubin MD (Professor Emeritus, Chair Emeritus) & Paul Okunieff MD (Philip Rubin Professor of Radiation Oncology, Chair) (Professor Emeritus, Chair Emeritus) &  (Philip Rubin Professor of Radiation Oncology, Chair)

  2. Department of Radiation Oncology, Departments of Radiation Oncology and Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 647, Rochester, NY, 14642, USA

    Louis S. Constine MD (Professor of Radiation Oncology and Pediatrics, Vice Chair) (Professor of Radiation Oncology and Pediatrics, Vice Chair)

  3. Department of Radiation Oncology, Duke University Medical Center, P.O. Box 3085, Durham, NC, 27710, USA

    Lawrence B. Marks MD (Professor) (Professor)

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© 2008 Springer-Verlag Berlin Heidelberg

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Willey, C.D., Hallahan, D.E. (2008). Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury. In: Rubin, P., Constine, L.S., Marks, L.B., Okunieff, P. (eds) Late Effects of Cancer Treatment on Normal Tissues. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49070-8_4

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  • DOI: https://doi.org/10.1007/978-3-540-49070-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-49069-2

  • Online ISBN: 978-3-540-49070-8

  • eBook Packages: MedicineMedicine (R0)

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