Auszug
Die Pathogenese autoimmuner Lebererkrankungen ist unklar, wird aber durch einen Toleranzverlust des Immunsystems gegenüber dem eigenen Lebergewebe verursacht. Ätiologisch werden hier virale und bakterielle Auslöser (Mimikry-Hypothese) impliziert, die vor dem Hintergrund einer polygenen immungenetischen Prädisposition des Betroffenen (HLA-Gene und nicht-HLA-Gene) zur Überwindung der immunologischen Toleranz führen. Schlüssige Beweise für diese Effekte liegen für die Autoimmunerkrankungen der Leber nicht vor.
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Strassburg, C.P., Vogel, A., Manns, M.P. (2007). Akute und chronische nichtvirale Hepatitiden: Autoimmunerkrankungen, Medikamente und Toxine. In: Schölmerich, J. (eds) Medizinische Therapie 2007 | 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48554-4_75
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