Skip to main content
  • 110 Accesses

Auszug

Pharmakodynamik beschreibt, was das Medikament »mit dem Körper macht«. Der zeitliche Verlauf der Plasmakonzentration nach Medikamentengabe wird durch die Pharmakokinetik beschrieben.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 39.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Weiterführende Literatur

  • Brynne L, Karlsson MO, Paalzow LK (1998) Concentration-effect relationship of l-propranolol and metoprolol in spontaneous hypertensive rats after exercise-induced tachycardia. J Pharmacol Exp Ther 286(3): 1152–1158

    PubMed  CAS  Google Scholar 

  • Garg V, Jusko WJ (1994) Pharmacodynamic modeling of nonsteroidal anti-inflammatory drugs: antipyretic effect of ibuprofen [letter]. Clin Pharmacol Ther 55(1): 87–88

    Article  PubMed  CAS  Google Scholar 

  • Hill AV (1910) The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. Journal J Physiol 40: iv–vii

    Google Scholar 

  • Holford NH, Sheiner LB (1982) Kinetics of pharmacologic response. Pharmacol Ther 16(2): 143–166

    Article  PubMed  CAS  Google Scholar 

  • Holford NH (1990) Concepts and usefulness of pharmacokinetic-pharmacodynamic modelling. Fundam Clin Pharmacol 4(Suppl 2):93s–101s

    Article  PubMed  Google Scholar 

  • Hull CJ, Van Beem HB, McLeod K, Sibbald A, Watson MJ (1978) A pharmacodynamic model for pancuronium. Br J Anaesth 50:1113–1123

    Article  PubMed  CAS  Google Scholar 

  • Kong AN, Ludwig EA, Slaughter RL, DiStefano PM, DeMasi J, Middleton E Jr et al (1989) Pharmacokinetics and pharmacodynamic modeling of direct suppression effects of methylprednisolone on serum cortisol and blood histamine in human subjects. Clin Pharmacol Ther 46(6): 616–628

    Article  PubMed  CAS  Google Scholar 

  • Lew KH, Ludwig EA, Milad MA, Donovan K, Middleton E Jr, Ferry JJ et al (1993) Gender-based effects on methylprednisolone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 54(4): 402–414

    Article  PubMed  CAS  Google Scholar 

  • Lu W, Bailey JM (2000) Reliability of pharmacodynamic analysis by logistic regression: a computer simulation study. Anesthesiology 92(4): 985–992

    Article  PubMed  CAS  Google Scholar 

  • Mandema JW, Danhof M (1992) Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs. Clin Pharmacokinet 23:191–215

    Article  PubMed  CAS  Google Scholar 

  • Mandema JW (1995) Population Pharmacokinetics and Pharmacodynamics. In: Welling PG, Tse FLS (eds) Pharmacokinetics. Marcel Dekker, New York, pp 411–450

    Google Scholar 

  • Minto CF, Howe C, Wishart S, Conway AJ, Handelsman DJ (1997) Pharmacokinetics and pharmacodynamics of nandrolone esters in oil vehicle: effects of ester, injection site and injection volume. J Pharmacol Exp Ther 281(1): 93–102

    PubMed  CAS  Google Scholar 

  • Schnider TW, Minto CF, Stanski DR (1994) The effect compartment concept in pharmacodynamic modelling. Anaesth Pharmacol Rev 2: 204–213

    CAS  Google Scholar 

  • Scott JC, Ponganis KV, Stanski DR (1985) EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 62: 234–241

    Article  PubMed  CAS  Google Scholar 

  • Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J (1979) Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin Pharmacol Ther 25:358–371

    PubMed  CAS  Google Scholar 

  • Sheiner LB (1969) Computer-aided long-term anticoagulation therapy. Comput Biomed Res 2(6): 507–518

    Article  PubMed  CAS  Google Scholar 

  • Shi J, Benowitz NL, Denaro CP, Sheiner LB (1993) Pharmacokineticpharmacodynamic modeling of caffeine: tolerance to pressor effects. Clin Pharmacol Ther 53: 6–14

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Schnider, T.W. (2007). Pharmakodynamik. In: Schölmerich, J. (eds) Medizinische Therapie 2007 | 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48554-4_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-48554-4_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-48553-7

  • Online ISBN: 978-3-540-48554-4

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics