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Neuronogenesis and the Early Events of Neocortical Histogenesis

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Book cover Mouse Brain Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 30))

Abstract

The neocortex is central to the most highly evolved processing functions of the mammalian brain. These functions are intimately related to the architecture and massive scale of the neocortex and its regional organization as components of distributed neural systems. The neurons of the mammalian neocortex, represented by a great diversity of distinct classes and subclasses (Lorente de No 1938; Cajal 1952) arise from a proliferative pseudostratified ventricular epithelium (PVE) at the surface of the embryonic ventricular cavities (His 1889; Sauer 1935; Sauer 1936; Boulder Committee 1970) (Fig. 1A). Various lines of evidence now provide a glimpse of the workings of the proliferative process which reveal its pervasive integration with the succession of histogenetic events that follow. Thus, there is now evidence to suggest that neurons are specified with respect to class in the course of neuronogenesis in the PVE (Parnavelas et al. 1991; Mione et al. 1994; Mione et al. 1997) and that the regional map of the neocortex is foreshadowed by a corresponding regional map of PVE (Rakic 1988). That is, the earliest events of specification of cell class and of regional specification appear to occur coordinately with neuronogenesis within the proliferative cells of the PVE (Takahashi et al. 1999a).

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Authors and Affiliations

  1. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA

    V. S. Caviness Jr & T. Takahashi

  2. Department of Pediatrics, Keio University School of Medicine, Tokyo 160, Japan

    T. Takahashi

  3. Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA

    R. S. Nowakowski

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  1. V. S. Caviness Jr
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  2. T. Takahashi
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  3. R. S. Nowakowski
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Editors and Affiliations

  1. Neurobiology Unit, University of Namur Medical School, 61, rue de Bruxelles, B-5000, Namur, Belgium

    André M. Goffinet

  2. Section of Neurobiology, Yale University School of Medicine, 333, Cedar Street, 06510, New Haven, CT, USA

    Pasko Rakic

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Caviness, V.S., Takahashi, T., Nowakowski, R.S. (2000). Neuronogenesis and the Early Events of Neocortical Histogenesis. In: Goffinet, A.M., Rakic, P. (eds) Mouse Brain Development. Results and Problems in Cell Differentiation, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48002-0_5

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