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Phosphatidylinositol 3-kinase

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Part of the book series: Springer Handbook of Enzymes ((HDBKENZYMES,volume 37))

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References

  1. Shibasaki, R; Homma, Y.; Takenawa, T.: Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form. J. Biol. Chem., 266, 8108–8114 (1991)

    PubMed  CAS  Google Scholar 

  2. Herbst, J.J.; Andrews, G.; Contillo, L.; Lamphere, L.; Gardner, J.; Lienhard, G.E.; Gibbs, E.M.: Potent activation of phosphatidylinositol 3-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains. Biochemistry, 33, 9376–9381 (1994)

    Article  PubMed  CAS  Google Scholar 

  3. Morgan, S.J.; Smith, A.D.; Parker, P.J.: Purification and characterization of bovine brain type I phosphatidylinositol kinase. Eur. J. Biochem., 191, 761–767 (1990)

    Article  PubMed  CAS  Google Scholar 

  4. Carpenter, C.L.; Duckworth, B.C.; Auger, K.R.; Cohen, B.; Schaffhausen, B.S.; Cantley, L.C.: Purification and characterization of phosphoinositide 3-kinase from rat liver. J. Biol. Chem., 265, 19704–19711 (1990)

    PubMed  CAS  Google Scholar 

  5. Fry, M.J.; Panayotou, G.; Dhand, R.; Ruiz-Larrea, E; Gout, I.; Nguyen, O.; Courtneidge, S.A.; Waterfield, M.D.: Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phos-phopeptide affinity columns. Biochem. J., 288, 383–393 (1992)

    PubMed  CAS  Google Scholar 

  6. Baxter, R.M.; Bramham, J.; Thomason, P.A.; Downes, C.P.; Carter, A.N.: Characterisation of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts. Biochem. Soc. Trans., 21, 359S (1993)

    PubMed  CAS  Google Scholar 

  7. Shibasaki, E; Fukui, Y.; Takenawa, T.: Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases. Biochem. J., 289, 227–231 (1993)

    PubMed  CAS  Google Scholar 

  8. Gout, I.; Dhand, R.; Panayotou, G.; Fry, M.J.; Hiles, I.; Otsu, M.; Waterfield, M.D.: Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 β protein by using the baculovirus expression system. Biochem. J., 288, 395–405 (1992)

    PubMed  CAS  Google Scholar 

  9. Ruiz-Larrea, E; Vicendo, P.; Yaish, P.; End, P.; Panayotou, G.; Fry, M.J.; Morgan, S.J.; Thompson, A.; Parker, P.J.; Waterfield, M.D.: Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex. Biochem. J., 290, 609–616 (1993)

    PubMed  CAS  Google Scholar 

  10. Hiles, I.D.; Otsu, M.; Volinia, S.; Fry, M.J.; Gout, I.; Dhand, R.; Panayotou, G.; Ruiz-Larrea, E; Thompson, A.; Totty, N.E; Hsuan, J.J.; Courtneidge, S.A.; Parker, P.J.; Waterfield, M.D.: Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell, 70, 419–429 (1992)

    Article  PubMed  CAS  Google Scholar 

  11. Ahmad, E; Li, P.-M.; Meyerovitch, J.; Goldstein, B.J.: Osmotic loading of neutralizing antibodies demonstrates a role of protein-tyrosine phosphatase IB in negative regulation of the insulin action pathway. J. Biol. Chem., 270, 20503–20508 (1995)

    Article  PubMed  CAS  Google Scholar 

  12. Aksoy LA.; Ramsey, M.J.; Fruman, D.A.; Aksoy, S.; Cantley, L.C.; Tucker, J.D.; Roberts, T.M.: Mouse phosphoinositide 3-kinase p110α gene: Cloning, structural organization, and localization to chromosome 3 Band B. Biochem. Biophys. Res. Commun., 262, 438–442 (1999)

    Article  PubMed  CAS  Google Scholar 

  13. Anderwald, C; Muller, G.; Koca, G.; Furnsinn, C.; Waldhausl, W.; Roden, M.: Short-term leptin-dependent inhibition of hepatic gluconeogenesis is mediated by insulin receptor substrate-2. Mol. Endocrinol, 16, 1612–1628 (2002)

    Article  PubMed  CAS  Google Scholar 

  14. Arcaro, A.; Zvelebil, M.J.; Wallasch, C.; Ullrich, A.; Waterfield, M.D.; Dom-in, J.: Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol. Cell. Biol, 20, 3817–3830 (2000)

    Article  PubMed  CAS  Google Scholar 

  15. Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.: Human phosphoinositide 3-kinase C2b, the role of calcium and the C2 domain in enzyme activity. J. Biol. Chem., 273, 33082–33090 (1998)

    Article  PubMed  CAS  Google Scholar 

  16. Asano, T.; Kanda, A.; Katagiri, H.; Nawano, M.; Ogihara, T.; Inukai, K.; Anai, M.; Fukushima, Y.; Yazaki, Y.; Kikuchi, M.; Hooshmand-Rad, R.; Heldin, C.-H.; Oka, Y; Funaki, M.: p110β is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity. J. Biol. Chem., 275, 17671–17676 (2000)

    Article  PubMed  CAS  Google Scholar 

  17. Axelsson, L.; Hellberg, C; Melander, F.; Smith, D.; Zheng, L.; Andersson, T.: Clustering of b2-integrins on human neutrophils activates dual signaling pathways to Ptdlns 3-kinase. Exp. Cell Res., 256, 257–263 (2000)

    Article  PubMed  CAS  Google Scholar 

  18. Bartlett, S.E.; Reynolds, A.J.; Tan, T.; Heydon, K.; Hendry, LA.: Differential mRNA expression and subcellular locations of PI3-kinase isoforms in sympathetic and sensory neurons. J. Neurosci. Res., 56, 44–53 (1999)

    Article  PubMed  CAS  Google Scholar 

  19. Bavelloni, A.; Santi, S.; Sirri, A.; Riccio, M.; Faenza, I.; Zini, N.; Cecchi, S.; Ferri, A.; Auron, P.; Maraldi, N.M.; Marmiroli, S.: Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells. J. Cell Sci., 112, 631–640 (1999)

    PubMed  CAS  Google Scholar 

  20. Baxter, R.M.; Bramham, J.; Thomason, P.A.; Downes, C.P.; Carter, A.N.: Characterization of phosphatidylinositol 3-kinase in PC12 cell extracts and isolation of the enzyme from rat brain extracts. Biochem. Soc. Trans., 21, 359S (1993)

    PubMed  CAS  Google Scholar 

  21. Baynes, K.C.R.; Beeton, C.A.; Panayotou, G.; Stein, R.; Soos, M.; Hansen, T.; Simpson, H.; O’Rahilly, S.; Shepherd, P.R.; Whitehead, J.P.: Natural variants of human p85a phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity. Diabetologia, 43, 321–331 (2000)

    Article  PubMed  CAS  Google Scholar 

  22. Beckwith, M.; Fenton, R.G.; Katona, I.M.; Longo, D.L.: Phosphatidylinosi-tol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human b-lymphoma cell line. Blood, 87, 202–210 (1996)

    PubMed  CAS  Google Scholar 

  23. Berggren, M.I.; Gallegos, A.; Dressier, L.A.; Modest, E.J.; Powis, G.: Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogs. Cancer Res., 53, 4297–4302 (1993)

    PubMed  CAS  Google Scholar 

  24. Bezerra, R.M.N.; Ueno, M.; Silva, M.S.; Tavares, D.Q.; Carvalho, C.R.O.; Saad, M.J.A.: A high fructose diet affects the early steps of insulin action in muscle and liver of rats. J. Nutr., 130, 1531–1535 (2000)

    PubMed  CAS  Google Scholar 

  25. Blondeau, R; Laporte, J.; Bodin, S.; Superti-Furga, G.; Payrastre, B.; Man-del, J.-L.: Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phos-phate pathway. Hum. Mol. Genet, 9, 2223–2229 (2000)

    PubMed  CAS  Google Scholar 

  26. Carrillo, J.J.; Ibares, B.; Esteban-Gamboa, A.; Feliu, J.E.: Involvement of both phosphatidylinositol 3-kinase and P44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin. Endocrinology, 142, 1057–1064 (2001)

    Article  PubMed  CAS  Google Scholar 

  27. Cataldi, A.; Di Pietro, R.; Centurione, L.; Grilli, A.; Cutroneo, G.; Miscia, S.: Phosphatidylinositol-3-kinase activation and atypical protein kinase C z phosphorylation characterize the DMSO signaling in erythroleukemia cells. Cell. Signal, 12, 667–672 (2000)

    Article  PubMed  CAS  Google Scholar 

  28. Chakravorty, A.; Joslyn, M.I.; Davis, J.S.: Characterization of insulin and insulin-like growth factor-I actions in the bovine luteal cell: Regulation of receptor tyrosine kinase activity, phosphatidylinositol 3-kinase, and deoxyribonucleic acid synthesis. Endocrinology, 133, 1331–1340 (1993)

    Article  PubMed  CAS  Google Scholar 

  29. Chantry, D.; Vojtek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C; Gray, P.W.; Cooper, J.A.; Hoekstra, M.F.: pllOd, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem., 272, 19236–19241 (1997)

    Article  PubMed  CAS  Google Scholar 

  30. Dadi, H.; Ke, S.; Roifman, CM.: Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity. Blood, 84, 1579–1586 (1994)

    PubMed  CAS  Google Scholar 

  31. Daniele, N.; Rajas, E; Payrastre, B.; Mauco, G.; Zitoun, C; Mithieux, G.: Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding. J. Biol. Chem., 274, 3597–3601 (1999)

    Article  PubMed  CAS  Google Scholar 

  32. Deuter-Reinhard, M.; Apell, G.; Pot, D.; Klippel, A.; Williams, L.T.; Kava-naugh, W.M.: SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and phosphatidylinositol 3-kinase. Mol. Cell. Biol, 17, 2559–2565 (1997)

    PubMed  CAS  Google Scholar 

  33. Domin, J.; Pages, E; Volinia, S.; Rittenhouse, S.E.; Zvelebil, M.J.; Stein, R.C.; Waterfield, M.D.: Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wort-mannin. Biochem. J., 326, 139–147 (1997)

    PubMed  CAS  Google Scholar 

  34. Domin, J.; Dhand, R.; Waterfield, M.D.: Binding to the platelet-derived growth factor receptor transiently activates the P85a-pll0α phosphoinositide 3-kinase complex in vivo. J. Biol. Chem., 271, 21614–21621 (1996)

    Article  PubMed  CAS  Google Scholar 

  35. End, P.; Gout, I.; Fry, M.J.; Panayotou, G.; Dhand, R.; Yonezawa, K.; Kasu-ga, M.; Waterfield, M.D.: A biosensor approach to probe the structure and function of the p85a subunit of the phosphatidylinositol 3-kinase complex. J. Biol. Chem., 268, 10066–10075 (1993)

    PubMed  CAS  Google Scholar 

  36. Fujioka, T.; Ui, M.: Involvement of insulin receptor substrates in epidermal growth factor induced activation of phosphatidylinositol 3-kinase in rat hepatocyte primary culture. Eur. J. Biochem., 268, 25–34 (2001)

    Article  PubMed  CAS  Google Scholar 

  37. Haefner, B.; Baxter, R.; Fincham, V.J.; Downes, C.P.; Frame, M.C.: Cooperation of Src homology domains in the regulated binding of phosphatidyl-inositol 3-kinase. A role for the Src homology 2 domain. J. Biol. Chem., 270, 7937–7943 (1995)

    Article  PubMed  CAS  Google Scholar 

  38. Hardy, S.; Langelier, Y.; Prentki, M.: Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. Cancer Res., 60, 6353–6358 (2000)

    PubMed  CAS  Google Scholar 

  39. Hauert, A.B.; Martinelli, S.; Marone, C; Niggli, V.: Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis. Int. J. Biochem. Cell Biol, 34, 838–854 (2002)

    Article  PubMed  CAS  Google Scholar 

  40. Herrera-Velit, P.; Reiner, N.E.: Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes. J. Immunol, 156, 1157–1165 (1996)

    PubMed  CAS  Google Scholar 

  41. Hong, Z.; Verma, D.P.S.: A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation. Proc. Natl. Acad. Sci. USA, 91, 9617–9621 (1994)

    Article  PubMed  CAS  Google Scholar 

  42. Karnitz, L.M.; Sutor, S.L.; Abraham, R.T.: The Src-Family Kinase, Fyn, Regulates the Activation of Phosphatidylinositol 3-Kinase in an Interleu-kin 2-responsive T cell Line. J. Exp. Med., 179, 1799–1808 (1994)

    Article  PubMed  CAS  Google Scholar 

  43. Kerouz, N.J.; Horsch, D.; Pons, S.; Kahn, C.R.: Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and phosphatidyl-inositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ ob) mouse. J. Clin. Invest, 100, 3164–3172 (1997)

    Article  PubMed  CAS  Google Scholar 

  44. Kessler, A.; Uphues, I.; Ouwens, D.M.; Till, M.; Eckel, J.: Diversification of cardiac insulin signaling involves the p85a/b subunits of phosphatidylinositol 3-kinase. Am. J. Physiol, 280, E65–E74 (2001)

    CAS  Google Scholar 

  45. Khan, F.A.; Goforth, P.B.; Zhang, M.; Satin, L.S.: Insulin activates ATP-sen-sitive K+ channels in pancreatic b-cells through a phosphatidylinositol 3-kinase-dependent pathway. Diabetes, 50, 2192–2198 (2001)

    Article  PubMed  CAS  Google Scholar 

  46. Knall, C; Young, S.; Nick, J.A.; Buhl, A.M.; Worthen, G.S.; Johnson, G.L.: Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils. J. Biol. Chem., 271, 2832–2838 (1996)

    Article  PubMed  CAS  Google Scholar 

  47. Krymskaya, V.P.; Hoffman, R.; Eszterhas, A.; Kane, S.; Ciocca, V.; Panet-tieri, R.A., Jr.: EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. Am. J. Physiol, 276, L246–L255 (1999)

    PubMed  CAS  Google Scholar 

  48. Le Marchand-Brustel, Y; Heydrick, S.J.; Jullien, D.; Gautier, N.; Van Ob-berghen, E.: Effect of insulin and insulin-like growth factor-I on glucose transport and its transporters in soleus muscle of lean and obese mice. Metab. Clin. Exp., 44, 18–23 (1995)

    Google Scholar 

  49. Liang, J.; Chen, J.K.; Schreiber, S.L.; Clardy J.: Crystal structure of PI3K SH3 domain at 2.0 A resolution. J. Mol. Biol, 257, 632–643 (1996)

    Article  PubMed  CAS  Google Scholar 

  50. Lu, P.-J.; Hsu, A.-L.; Wang, D.-S.; Yan, H.Y.; Yin, H.L.; Chen, C.-S.: Phos-phoinositide 3-kinase in rat liver nuclei. Biochemistry, 37, 5738–5745 (1998)

    Article  PubMed  CAS  Google Scholar 

  51. Marandi, S.; De Keyser, N.; Saliez, A.; Maernoudt, A.-S.; Sokal, E.M.; Stil-mant, C; Rider, M.H.; Buts, J.-P.: Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases. Am. J. Physiol., 280, G229–G240 (2001)

    CAS  Google Scholar 

  52. Marshall, A.J.; Krahn, A.K.; Ma, K.; Duronio, V.; Hou, S.: TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Mol. Cell. Biol, 22, 5479–5491 (2002)

    Article  PubMed  CAS  Google Scholar 

  53. Mauvais-Jarvis, R; Ueki, K.; Fruman, D.A.; Hirshman, M.F.; Sakamoto, K.; Goodyear, L.J.; Iannacone, M.; Accili, D.; Cantley, L.C.; Kahn, C.R.: Reduced expression of the murine p85a subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J. Clin. Invest., 109, 141–149 (2002)

    PubMed  CAS  Google Scholar 

  54. Minshall, C; Arkins, S.; Freund, G.G.; Kelley, K.W.: Requirement for phosphatidylinositol 3’-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. J. Immunol, 156, 939–947 (1996)

    PubMed  CAS  Google Scholar 

  55. Miyakawa, Y.; Rojnuckarin, P.; Habib, T.; Kaushansky K.: Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. J. Biol. Chem., 276, 2494–2502 (2001)

    Article  PubMed  CAS  Google Scholar 

  56. Molendiik, A.J.; Irvine, R.E.: Inositide signaling in Chlamydomonas: characterization of a phosphatidylinositol 3-kinase gene. Plant Mol. Biol., 37, 53–66 (1998)

    Article  Google Scholar 

  57. Molz, L.; Chen, Y.-W.; Hirano, M.; Williams, L.T.: CpK is a novel class of Drosophila Ptdlns 3-kinase containing a C2 domain. J. Biol. Chem., 271, 13892–13899 (1996)

    Article  PubMed  CAS  Google Scholar 

  58. Muller, G.; Wied, S.; Piossek, C; Bauer, A.; Bauer, J.; Frick, W.: Convergence and divergence of the signaling pathways for insulin and phospho-inositolglycans. Mol. Med., 4, 299–323 (1998)

    PubMed  CAS  Google Scholar 

  59. Ogihara, T.; Asano, T.; Ando, K.; Chiba, Y; Sekine, N.; Sakoda, H.; Anai, M.; Onishi, Y.; Fuiishiro, M.; Ono, H.; Shoiima, N.; Inukai, K.; Fukushima, Y.; Kikuchi, M.; Fujita, T.: Insulin resistance with enhanced insulin signaling in high-salt diet-fed rats. Diabetes, 50, 573–583 (2001)

    Article  PubMed  CAS  Google Scholar 

  60. Okada, T.; Sakuma, L.; Fukui, Y; Hazeki, O.; Ui, M.: Blockage of chemo-tactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase. J. Biol. Chem., 269, 3563–3567 (1994)

    PubMed  CAS  Google Scholar 

  61. Okada, T.; Kawano, Y; Sakakibara, T.; Hazeki, O.; Ui, M.: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J. Biol. Chem., 269, 3568–3573 (1994)

    PubMed  CAS  Google Scholar 

  62. Pellegatta, R; Chierchia, S.L.; Zocchi, M.R.: Functional association of platelet endothelial cell adhesion molecule-1 and phosphoinositide 3-kinase in human neutrophils. J. Biol. Chem., 273, 27768–27771 (1998)

    Article  PubMed  CAS  Google Scholar 

  63. Phillips, W.A.; St. Clair, R; Munday, A.D.; Thomas, R.J.S.; Mitchell, C.A.: Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors. Cancer, 83, 41–47 (1998)

    Article  PubMed  CAS  Google Scholar 

  64. Rondinone, CM.; Carvalho, E.; Rahn, T.; Manganiello, V.C.; Degerman, E.; Smith, U.P.: Phosphorylation of PDE3B by phosphatidylinositol 3-kinase associated with the insulin receptor. J. Biol. Chem., 275, 10093–10098 (2000)

    Article  PubMed  CAS  Google Scholar 

  65. Ruiz-Larrea, R; Vicendo, P.; Yaish, P.; End, P.; Panayotou, G.; Fry, M.J.; Morgan, S.J.; Thompson, A.; Parker, P.J.; Waterfield, M.D.: Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex. Biochem. J., 290, 609–616 (1993)

    PubMed  CAS  Google Scholar 

  66. Saad, M.J.A.; Folli, F.; Kahn, C.R.: Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells. Endocrinology, 136, 1579–1588 (1995)

    Article  PubMed  CAS  Google Scholar 

  67. Sato, M.; Bryant, H.U.; Dodge, J.A.; Davis, H.; Matter, W.R; Vlahos, C.J.: Effects of wortmannin analogs on bone in vitro and in vivo. J. Pharmacol. Exp. Ther., 277, 543–550 (1996)

    PubMed  CAS  Google Scholar 

  68. Shibasaki, R; Fukui, Y.; Takenawa, T.: Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases. Biochem. J., 289, 227–231 (1993)

    PubMed  CAS  Google Scholar 

  69. Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; et al: Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science, 269, 690–693 (1995)

    Article  PubMed  CAS  Google Scholar 

  70. Tang, X.; Downes, C.P.: Purification and characterization of Gbg-respon-sive phosphoinositide 3-kinases from pig platelet cytosol. J. Biol. Chem., 272, 14193–14199 (1997)

    Article  PubMed  CAS  Google Scholar 

  71. Thomson, F.J.; Moyes, C; Scott, P.H.; Plevin, R.; Gould, G.W.: Lysopho-sphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3’-kinase with distinct properties. Biochem. J., 316, 161–166 (1996)

    PubMed  CAS  Google Scholar 

  72. Tremblay, R; Lavigne, C; Jacques, H.; Marette, A.: Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (z/1) activities. Diabetes, 50, 1901–1910 (2001)

    Article  PubMed  CAS  Google Scholar 

  73. Velloso, L.A.; Carvalho, C.R.O.; Rojas, F.A.; Folli, R; Saad, M.J.A.: Insulin signaling in heart involves insulin receptor substrates-1 and-2, activation of phosphatidylinositol 3-kinase and the JAK 2-growth related pathway. Cardiovasc. Res., 40, 96–102 (1998)

    Article  PubMed  CAS  Google Scholar 

  74. Virbasius, J.V.; Guilherme, A.; Czech, M.P.: Mouse pl70 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J. Biol. Chem., 271, 13304–13307 (1996)

    Article  PubMed  CAS  Google Scholar 

  75. Volinia, S.; Dhand, R.; Vanhaesebroeck, B.; MacDougall, L.; Stein, R.; Zve-lebil, M.J.; Domin, J.; Panaretou, C; Waterfield, M.D.: A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vpsl5p protein sorting system. EMBO J., 14, 3339–3348 (1995)

    PubMed  CAS  Google Scholar 

  76. Wang, D.; Sul, H.S.: Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt. J. Biol. Chem., 273, 25420–25426 (1998)

    Article  PubMed  CAS  Google Scholar 

  77. Wang, Q.; Bilan, P.J.; Tsakiridis, T.; Hinek, A.; Klip, A.: Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem. J., 331, 917–928 (1998)

    PubMed  CAS  Google Scholar 

  78. Wilden, P.A.; Kahn, C.R.: The level of insulin receptor tyrosine kinase activity modulates the activities of phosphatidylinositol 3-kinase, microtu-bule-associated protein, and S6 kinases. Mol. Endocrinol., 8, 558–567 (1994)

    Article  PubMed  CAS  Google Scholar 

  79. Yang, J.; Clarke, J.F.; Ester, C.J.; Young, P.W; Kasuga, M.; Holman, G.D.: Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells. Biochem. J., 313, 125–131 (1996)

    PubMed  CAS  Google Scholar 

  80. Yu, Y; Sato, J.D.: MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor. J. Cell. Physiol, 178, 235–246 (1999)

    Article  PubMed  CAS  Google Scholar 

  81. Zhou, J.-H.; Broussard, S.R.; Strle, K.; Freund, G.G.; Johnson, R.W.; Dantzer, R.; Kelley, K.W.: IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3’-kinase. J. Immunol, 167, 4436–4442 (2001)

    PubMed  CAS  Google Scholar 

  82. Zini, N.; Ognibene, A.; Bavelloni, A.; Santi, S.; Sabatelli, P.; Baldini, N.; Scotlandi, K.; Serra, M.; Maraldi, N.M.: Cytoplasmic and nuclear localization sites of phosphatidylinositol 3-kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells. Histochem. Cell Biol, 106, 457–464 (1996)

    PubMed  CAS  Google Scholar 

  83. Arcaro, A.; Volinia, S.; Zvelebil, M.J.; Stein, R.; Watton, S.J.; Layton, M.J.; Gout, I.; Ahmadi, K.; Downward, J.; Waterfield, M.D.: Human phosphoino-sitide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity. J. Biol. Chem., 273, 33082–33090 (1998)

    Article  PubMed  CAS  Google Scholar 

  84. Brown, R.A.; Ho, L.K.; Weber-Hall, S.J.; Shipley, J.M.; Fry, M.J.: Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. Biochem. Biophys. Res. Com-mun., 233, 537–544 (1997)

    Article  CAS  Google Scholar 

  85. Cafferkey, R.; Young, P.R.; McLaughlin, M.M.; Bergsma, D.J.; Koltin, Y; Sathe, G.M.; Faucette, L.; Eng, W.K.; Johnson, R.K.; Livi, G.P.: Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol. Cell. Biol., 13, 6012–6023 (1993)

    PubMed  CAS  Google Scholar 

  86. Chantry, D.; Voitek, A.; Kashishian, A.; Holtzman, D.A.; Wood, C; Gray, P.W; Cooper, J.A.; Hoekstra, M.F.: pll0δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J. Biol. Chem., 272, 19236–19241 (1997)

    Article  PubMed  CAS  Google Scholar 

  87. Eck, R.; Bruckmann, A.; Wetzker, R.; Kunkel, W.: A phosphatidylinositol 3-kinase of Candida albicans: molecular cloning and characterization. Yeast, 16, 933–944 (2000)

    Article  PubMed  CAS  Google Scholar 

  88. Helliwell, S.B.; Wagner, R; Kunz, J.; Deuter-Reinhard, M.; Henriquez, R.; Hall, M.N.: TORI and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol. Biol. Cell, 5, 105–118 (1994)

    PubMed  CAS  Google Scholar 

  89. Herman, P.K.; Emr, S.D.: Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cere-visiae. Mol. Cell. Biol, 10, 6742–6754 (1990)

    PubMed  CAS  Google Scholar 

  90. Hiles, I.D.; Otsu, M.; Volinia, S.; Fry, M.J.; Gout, I.; Dhand, R.; Panayotou, G.; Ruiz-Larrea, E; Thompson, A.; Totty, N.F.; et al: Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell, 70, 419–429 (1992)

    Article  PubMed  CAS  Google Scholar 

  91. Hong, Z.; Verma, D.P.: A phosphatidylinositol 3-kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation. Proc. Natl. Acad. Sci. USA, 91, 9617–9621 (1994)

    Article  PubMed  CAS  Google Scholar 

  92. Huang, M.E.; Manus, V.; Chuat, J.C.; Galibert, F.: Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI. Yeast, 12, 869–875 (1996)

    Article  PubMed  CAS  Google Scholar 

  93. Kimura, K.; Miyake, S.; Makuuchi, M.; Morita, R.; Usui, T.; Yoshida, M.; Horinouchi, S.; Fukui, Y.: Phosphatidylinositol-3 kinase in fission yeast: a possible role in stress responses. Biosci. Biotechnol. Biochem., 59, 678–682 (1995)

    Article  PubMed  CAS  Google Scholar 

  94. Klippel, A.; Escobedo, J.A.; Hirano, M.; Williams, L.T.: The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell. Biol., 14, 2675–2685 (1994)

    PubMed  CAS  Google Scholar 

  95. Kunz, J.; Henriquez, R.; Schneider, U.; Deuter-Reinhard, M.; Mowa, N.R.; Hall, M.N.: Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for Gl progression. Cell, 73, 585–596 (1993)

    Article  PubMed  CAS  Google Scholar 

  96. Leevers, S.J.; Weinkove, D.; MacDougall, L.K.; Hafen, E.; Waterfield, M.D.: The Drosophila phosphoinositide 3-kinase Dpi 10 promotes cell growth. EMBO J., 15, 6584–6594 (1996)

    PubMed  CAS  Google Scholar 

  97. Linassier, C; MacDougall, L.K.; Domin, J.; Waterfield, M.D.: Molecular cloning and biochemical characterization of a Drosophila phosphatidyli-nositol-specific phosphoinositide 3-kinase. Biochem. J., 321, 849–856 (1997)

    PubMed  CAS  Google Scholar 

  98. MacDougall, L.K.; Domin, J.; Waterfield, M.D.: A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. Curr. Biol, 5, 1404–1415 (1995)

    Article  PubMed  CAS  Google Scholar 

  99. McWhirter, J.R.; Galasso, D.L.; Wang, J.Y.: A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins. Mol. Cell. Biol, 13, 7587–7595 (1993)

    PubMed  CAS  Google Scholar 

  100. Misawa, H.; Ohtsubo, M.; Copeland, N.G.; Gilbert, D.J.; Jenkins, N.A.; Yoshimura, A.: Cloning and characterization of a novel class II phospho-inositide 3-kinase containing C2 domain. Biochem. Biophys. Res. Com-mun., 244, 531–539 (1998)

    Article  CAS  Google Scholar 

  101. Molz, L.; Chen, Y.W.; Hirano, M.; Williams, L.T.: Cpk is a novel class of Drosophila Ptdlns 3-kinase containing a C2 domain. J. Biol. Chem., 271, 13892–13899 (1996)

    Article  PubMed  CAS  Google Scholar 

  102. Morris, J.Z.; Tissenbaum, H.A.; Ruvkun, G.: A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabdi-tis elegans. Nature, 382, 536–539 (1996)

    Article  PubMed  CAS  Google Scholar 

  103. Ono, R; Nakagawa, T.; Saito, S.; Owada, Y.; Sakagami, H.; Goto, K.; Suzuki, M.; Matsuno, S.; Kondo, H.: A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration. J. Biol. Chem., 273, 7731–7736 (1998)

    Article  PubMed  CAS  Google Scholar 

  104. Petrovic, U.; Gunde-Cimerman, N.; Plemenitas, A.: Cellular responses to environmental salinity in the halophilic black yeast Hortaea werneckii. Mol. Microbiol., 45, 665–672 (2002)

    Article  PubMed  CAS  Google Scholar 

  105. Rozycka, M.; Lu, Y.J.; Brown, R.A.; Lau, M.R.; Shipley, J.M.; Fry, M.J.: cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2r, and chromosomal assignment of this gene (PIK3C2G) to 12pl2. Genomics, 54, 569–574 (1998)

    Article  PubMed  CAS  Google Scholar 

  106. Schu, P.V.; Takegawa, K.; Fry, M.J.; Stack, J.H.; Waterfield, M.D.; Emr, S.D.: Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science, 260, 88–91 (1993)

    Article  PubMed  CAS  Google Scholar 

  107. Stephens, L.R.; Eguinoa, A.; Erdjument-Bromage, H.; Lui, M.; Cooke, E; Coadwell, J.; Smrcka, A.S.; Thelen, M.; Cadwallader, K.; Tempst, P.; Hawkins, P.T.: The G βγ sensitivity of a PI3K is dependent upon a tightly associated adaptor, pl0l. Cell, 89, 105–114 (1997)

    Article  PubMed  CAS  Google Scholar 

  108. Stirdivant, S.M.; Ahern, J.; Conroy R.R.; Barnett, S.F.; Ledder, L.M.; Oliff, A.; Heimbrook, D.C.: Cloning and mutagenesis of the pi 10a subunit of human phosphoinositide 3’-hydroxykinase. Bioorg. Med. Chem., 5, 65–74 (1997)

    Article  PubMed  CAS  Google Scholar 

  109. Stoyanov, B.; Volinia, S.; Hanck, T.; Rubio, I.; Loubtchenkov, M.; Malek, D.; Stoyanova, S.; Vanhaesebroeck, B.; Dhand, R.; Nurnberg, B.; et al.: Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science, 269, 690–693 (1995)

    Article  PubMed  CAS  Google Scholar 

  110. Takegawa, K.; DeWald, D.B.; Emr, S.D.: Schizosaccharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology. J. Cell Sci, 108, 3745–3756 (1995)

    PubMed  CAS  Google Scholar 

  111. Vanhaesebroeck, B.; Welham, M.J.; Kotani, K.; Stein, R.; Warne, P.H.; Zve-lebil, M.J.; Higashi, K.; Volinia, S.; Downward, J.; Waterfield, M.D.: P110δ, a novel phosphoinositide 3-kinase in leukocytes. Proc. Natl. Acad. Sci. USA, 94, 4330–4335 (1997)

    Article  CAS  Google Scholar 

  112. Volinia, S.; Hiles, I.; Ormondroyd, E.; Nizetic, D.; Antonacci, R.; Rocchi, M.; Waterfield, M.D.: Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110α (PIK3CA) gene. Genomics, 24, 472–477 (1994)

    Article  PubMed  CAS  Google Scholar 

  113. Weisman, R.; Choder, M.: The fission yeast TOR homolog, torl+, is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem., 276, 7027–7032 (2001)

    Article  PubMed  CAS  Google Scholar 

  114. Welters, P.; Takegawa, K.; Emr, S.D.; Chrispeels, M.J.: AtVPS34, a phospha-tidylinositol 3-kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain. Proc. Natl. Acad. Sci. USA, 91, 11398–11402 (1994)

    Article  PubMed  CAS  Google Scholar 

  115. Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al: The genome sequence of Schizosaccharomyces pombe. Nature, 415, 871–880 (2002)

    Article  PubMed  CAS  Google Scholar 

  116. Zhou, K.; Takegawa, K.; Emr, S.D.; Firtel, R.A.: A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian pi 10 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol. Cell. Biol, 15, 5645–5656 (1995)

    PubMed  CAS  Google Scholar 

  117. Vanhaesebroeck, B.; Leevers, S.J.; Ahmadi, K.; Timms, J.; Katso, R.; Dris-coll, P.C.; Woscholski, R.; Parker, P.J.; Waterfield, M.D.: Synthesis and function of 3-phosphorylated inositol lipids. Annu. Rev. Biochem., 70, 535–602 (2001)

    Article  PubMed  CAS  Google Scholar 

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(2007). Phosphatidylinositol 3-kinase. In: Schomburg, D., Scomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47818-8_25

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