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Adenoid Cystic Carcinoma

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Histopathology of the Salivary Glands

Abstract

Adenoid cystic carcinoma (ADCC) in its classic form has a very characteristic sieve-like pattern of small malignant, often basaloid cells. The tumour was described by Robin and Laboulbene and by Billroth in the mid-nineteenth century and first termed cylindroma (Zylindrome). The term adenoid cystic carcinoma was coined by Spies in 1930 but gained wider acceptance first after the classic work on salivary gland tumours by Foote and Frazell in the 1950’s. Several synonyms are still in use but more seldom so, such as cribriform adenocarcinoma (which nowadays also carries another connotation; please see Chap. 15), cylindromatous adenocarcinoma, adenocystic carcinoma and adenoid cystic adenocarcinoma. Adenoid cystic carcinoma consists of ductal (luminal) and basal/myoepithelial (abluminal) cells that usually are arranged in a typical cribriform (glandular) pattern but also in tubular and solid growth patterns. It has a slow but relentless progression with long-term (15–20 years) fatal outcome inasmuch as 60–90 % of cases and is hence always best regarded as a high-grade malignancy. To classify all adenoid cystic carcinoma to be of high-grade malignancy is a practical approach, possibly regarded as pragmatic by some, but makes the concept of high-grade transformation, or dedifferentiation, possibly of less importance in cases of ADCC, contrary to, e.g. acinic cell carcinoma.

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  1. Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal

    Henrik Hellquist

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    Alena Skalova

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Hellquist, H., Skalova, A. (2014). Adenoid Cystic Carcinoma. In: Histopathology of the Salivary Glands. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46915-5_8

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