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Adhesive Events in Retinal Development and Function: The Role of Integrin Receptors

  • Chapter
Vertebrate Eye Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 31))

Summary

Cells in the developing retina contact a vast array of molecular cues in their microenvironment that are thought to guide their development. Many of these cues are embedded in the surface of neighboring cells or deposited within the extracellular matrix (ECM). Evidence has accumulated that cell-cell and cell-ECM interactions are essential in many phases of neural development, including neuroblast migration, determination of cell fate, axon outgrowth and synapse formation. In this chapter, we examine the developmental and functional roles fulfilled by integrins, a family of receptors for ECM molecules and cell adhesion molecules (CAMs). We have approached this problem by addressing a series of three questions: (1) which integrins are expressed in developing retina? (2) when and where are they expressed? and, (3) what functions do they carry out? Integrins have previously been implicated in axon extension, but new evidence suggests that they are also involved in earlier developmental events in preaxonal neuroblasts. High levels of expression of at least eight integrin subunits have been documented in these young retinal cells, and integrins containing the β1 subunit have been implicated in migration of adolescent retinal ganglion cells. Integrin expression persists through adulthood, both in the retina and in the neighboring layer of the retinal pigment epithelium (RPE). The integrin αvβ5 has been shown to reside on the apical surface of the RPE and has been implicated in the phagocytosis of shed photoreceptor outer segments.

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Author information

Authors and Affiliations

  1. Neuroscience Research Institute, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California, 93106, USA

    Gordon M. Cann

Authors
  1. Dennis O. Clegg
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  2. Linda H. Mullick
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  3. Kevin L. Wingerd
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  4. Hai Lin
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  5. Jason W. Atienza
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  6. Amy D. Bradshaw
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  7. Dennis B. Gervin
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  8. Gordon M. Cann
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Editor information

Editors and Affiliations

  1. Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, 750 Washington Street, Box 450, Boston, MA, 02111, USA

    M. Elizabeth Fini Ph. D.

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© 2000 Springer-Verlag Berlin Heidelberg

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Clegg, D.O. et al. (2000). Adhesive Events in Retinal Development and Function: The Role of Integrin Receptors. In: Fini, M.E. (eds) Vertebrate Eye Development. Results and Problems in Cell Differentiation, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46826-4_8

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  • DOI: https://doi.org/10.1007/978-3-540-46826-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53678-6

  • Online ISBN: 978-3-540-46826-4

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