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Heat Shock Effects in Snail Development

  • Chapter
Heat Shock and Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 17))

Abstract

In the study of the mechanisms underlying embryonic development, a variety of noxious treatments have been applied in the past. At the present, disturbing normal development by external influences remains a common method in experimental embryology. Heat shock has been used for a long time in this sense in a variety of organisms such as Amphibia, chicks, snails, Drosophila,and so on. These studies have in common that the defects are stage specific, depending on the period of development at which heat shock is applied. Which developmental biologist could foresee that heat shock would play such a pivotal role in molecular biology in the research on gene regulation? The discovery of the induction of a unique set of puffs by heat shock (Ritossa 1962) opened this field of investigation. Only about one decade later, it was demonstrated that a specific set of polypeptides was synthesized after exposure to heat, corresponding to a specific set of mRNAs. The response to heat is now known as a universal reaction of almost every living organism. It is even a response to stress in general. The heat shock genes and their products in different species show a high degree of homology. Their conservation during evolution suggests the early development of an essential function in all organisms (Schlesinger et al. 1982; Craig 1985; Lindquist 1986). This has been strengthened by the fact that their activity is not only influenced by external factors, but also fluctuates intrinsically, e.g., during the cell division cycle and embryonic development and differentiation. At the present, heat shock research is again concentrating on embryology. It is focused upon two main levels at which heat shock and development are cross-linked, i.e., at the levels of morphogenesis and gene regulation. Although these fields of investigation are still rather separate, they may converge in the future when our insights in both will have progressed.

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Authors and Affiliations

  1. Department of Molecular Cell Biology, University of Utrecht, Padualaan 8, P.O. Box 80.056, 3508 TB, Utrecht, The Netherlands

    Elida K. Boon-Niermeijer

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  1. Elida K. Boon-Niermeijer
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  1. Department of Molecular and Cell Biology, The University of Connecticut, 75 North Eagleville Road, 06269-3044, Storrs, CT, USA

    Lawrence Hightower

  2. Institut für Biochemie der Pflanzen, Weinberg 3, D-4050, Halle (O), Federal Republic of Germany

    Lutz Nover

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© 1991 Springer-Verlag Berlin Heidelberg

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Boon-Niermeijer, E.K. (1991). Heat Shock Effects in Snail Development. In: Hightower, L., Nover, L. (eds) Heat Shock and Development. Results and Problems in Cell Differentiation, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46712-0_2

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  • DOI: https://doi.org/10.1007/978-3-540-46712-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21993-5

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