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Transcriptional Regulation of Human Hsp70 Genes: Relationship Between Cell Growth, Differentiation, Virus Infection, and the Stress Response

  • Chapter
Heat Shock and Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 17))

Abstract

Our understanding of the regulation of the 70-kD family of heat shock genes during human development is necessarily reliant on information obtained from animal studies and from human cell lines which can be induced to differentiate. It has been reported that expression of certain members of the mouse 70-kD heat shock family is regulated during embryogenesis (Bensaude et al. 1983; Bensaude and Morange 1983; Kothary et al. 1987; see Chap. 10) and during spermatogenesis (Krawczyk et al. 1987a; Zakeri and Wolgemuth 1987; Allen et al. 1988; Zakeri et al. 1988; see Chap. 9). Such studies suggest that expression of human heat-shock genes is developmentally regulated. One can also argue, based on our current understanding of the function of this family of genes, that the 70-kD heat shock proteins must play an important role during development and that their expression must, of necessity, be tightly regulated during this process. Heat shock proteins appear to participate in the assembly-disassembly of macromolecular complexes (Georgopoulos and Ang 1990), in transport of polypeptides into organelles such as mitochondria (Chirico et al. 1988; Deshaies et al. 1988; Kang et al. 1990), in trafficking of polypeptides through the endoplasmic reticulum (Dorner et al. 1987), in vesicular uncoating (Ungewickell 1985), in the protection of newly synthesized proteins (Beckmann et al. 1990), and in protein degradation (Chiang et al. 1989). All of these processes must be critical to the successful execution of developmental programs, during which cells alter their patterns of protein synthesis and secretion respond to chemical and hormonal mediators, undergo morphological changes, migrate and interact with other cells, and undergo changes in their growth state. Considering also, as will be detailed in this chapter, the unique ability of the human hsp70 genes to show altered expression in response to environmental stimuli, it seems quite likely that the expression of these genes is highly regulated during development.

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Authors and Affiliations

  1. Dept. of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, Illinois, 60208, USA

    Benette Phillips & Richard I. Morimoto

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  1. Benette Phillips
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  2. Richard I. Morimoto
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Editors and Affiliations

  1. Department of Molecular and Cell Biology, The University of Connecticut, 75 North Eagleville Road, 06269-3044, Storrs, CT, USA

    Lawrence Hightower

  2. Institut für Biochemie der Pflanzen, Weinberg 3, D-4050, Halle (O), Federal Republic of Germany

    Lutz Nover

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© 1991 Springer-Verlag Berlin Heidelberg

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Phillips, B., Morimoto, R.I. (1991). Transcriptional Regulation of Human Hsp70 Genes: Relationship Between Cell Growth, Differentiation, Virus Infection, and the Stress Response. In: Hightower, L., Nover, L. (eds) Heat Shock and Development. Results and Problems in Cell Differentiation, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46712-0_12

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  • DOI: https://doi.org/10.1007/978-3-540-46712-0_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21993-5

  • Online ISBN: 978-3-540-46712-0

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