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Mammalian Carbohydrate Recognition Systems pp 105–121Cite as

Structure and Function of the Macrophage Mannose Receptor

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 33))

Abstract

The mannose receptor acts as a molecular scavenger by mediating Ca2+-dependent recognition and internalization of glycoconjugates terminating in mannose, N-acetylglucosamine or fucose. The receptor was identified when it was found that glycoproteins terminating in GlcNAc or mannose, including lysosomal enzymes, are rapidly cleared from the bloodstream by the liver (Schlesinger et al. 1976). The mannose receptor was found to be located on hepatic endothelial cells and Kupffer cells but not on hepatocytes (Schlesinger et al. 1978). The receptor has since been found on most types of tissue macrophages, including those of the placenta, but not on circulating monocytes (Shepherd et al. 1982). The retinal pigmented epithelium, a phagocytic cell layer, also expresses the mannose receptor (Shepherd et al. 1991). More recently, the mannose receptor has been identified on CD1-positive dendritic cells and Langerhan’s cells (Sallusto et al. 1995; Condaminet et al. 1998).

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Authors and Affiliations

  1. Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK

    Maureen E. Taylor

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  1. Maureen E. Taylor
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Editors and Affiliations

  1. The Wellcome Trust Building, Dept. of Biochemistry, University of Dundee, DD1 4HN, Dundee, Scotland

    Paul R. Crocker

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© 2001 Springer-Verlag Berlin Heidelberg

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Taylor, M.E. (2001). Structure and Function of the Macrophage Mannose Receptor. In: Crocker, P.R. (eds) Mammalian Carbohydrate Recognition Systems. Results and Problems in Cell Differentiation, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46410-5_6

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  • DOI: https://doi.org/10.1007/978-3-540-46410-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53670-0

  • Online ISBN: 978-3-540-46410-5

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