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Targeted Therapies in Cancer pp 7–24Cite as

Oncogenic Signaling Pathways and Deregulated Target Genes

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 176))

Abstract

A limited number of somatic mutations are known to trigger malignancy via chronic activation of cellular signaling pathways. High-throughput analysis of gene expression in cancer cells has revealed a plethora of deregulated genes by far exceeding the number of known genetic alterations. Targeted tumor therapy takes advantage of deregulated signaling in cancer. However, cancer cells may evade successful therapy, e.g., targeting oncogenic kinases, due to mutation of the target protein or to resistance mechanisms acting downstream of or parallel to the therapeutic block. To improve therapy and molecular diagnostics, we need detailed information on the wiring of pathway components and targets that ultimately execute the malignant properties of advanced tumors. Here we review work on Ras-mediated signal transduction and Ras pathway- responsive targets. We introduce the concept of signal-regulated transcriptional modules comprising groups of target genes responding to individual branches of the pathway network. Furthermore, we discuss functional approaches based on RNA interference for elucidating critical nodes in oncogenic signaling and the targets essential for malignancy.

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Authors and Affiliations

  1. Laboratory of Molecular Tumor Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Reinhold Schäfer PhD, Anja Schramme PhD, Oleg I. Tchernitsa MD, PhD & Christine Sers PhD

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  1. Reinhold Schäfer PhD
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  2. Anja Schramme PhD
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  3. Oleg I. Tchernitsa MD, PhD
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  4. Christine Sers PhD
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Editors and Affiliations

  1. Institut für Pathologie, Charité Humboldt-Universität zu Berlin, Schumanstr. 20-21, 10117, Berlin, Germany

    Manfred Dietel

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© 2007 Springer-Verlag Berlin Heidelberg

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Schäfer, R., Schramme, A., Tchernitsa, O.I., Sers, C. (2007). Oncogenic Signaling Pathways and Deregulated Target Genes. In: Dietel, M. (eds) Targeted Therapies in Cancer. Recent Results in Cancer Research, vol 176. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46091-6_2

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  • DOI: https://doi.org/10.1007/978-3-540-46091-6_2

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