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Role of Afferent Activity in the Development of Cortical Specification

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Book cover Cortical Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 39))

Summary

The surgical cross-modal rewiring paradigm is an experimental method for examining the physiological and anatomical consequences of exposing developing cortical subregions to specific types of patterned sensory inputs. Data from these experiments provide strong inferences about the role of extrinsic (subcortical) cortical inputs in shaping the local cortical networks that organize and process sensory information. Behavioral results from this work also suggest that such activity (and activity in general) is a profound organizer of cerebral connectivity. We discuss one future direction of these studies: the implication that extrinsic inputs regulate developmental genes that are responsible for refining the connectivity within local circuits, and a strategy to discover and characterize such genes.

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Author information

Authors and Affiliations

  1. The Center for Learning and Memory, Cambridge, Massachusetts, 02139, USA

    Alvin W. Lyckman & Mriganka Sur

  2. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, E25-235, Cambridge, Massachusetts, 02139, USA

    Mriganka Sur

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  1. Alvin W. Lyckman
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  2. Mriganka Sur
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Editors and Affiliations

  1. Department of Biology, Morgan State University, Cold Spring Lane and Hillen Road, Baltimore, MD, 21251, USA

    Christine Hohmann

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© 2002 Springer-Verlag Berlin Heidelberg

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Lyckman, A.W., Sur, M. (2002). Role of Afferent Activity in the Development of Cortical Specification. In: Hohmann, C. (eds) Cortical Development. Results and Problems in Cell Differentiation, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-46006-0_7

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  • DOI: https://doi.org/10.1007/978-3-540-46006-0_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53665-6

  • Online ISBN: 978-3-540-46006-0

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