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The Genetics of Murine Skeletal Muscle Biogenesis

  • Chapter
Vertebrate Myogenesis

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 38))

Abstract

Skeletal muscle formation involves a complex interplay of cell movements, cell-cell signalling and the activation of key intracellular genes. In the mouse, the myogenic regulatory factors (MRFs) Myf5 and Myod, act as the gatekeepers into the skeletal muscle lineage. Since this entry point into myogenesis was described, more interest has focused on the immediate upstream and downstream events that control the establishment of the skeletal muscle programme. This review is centred on how certain key regulatory genes are involved in establishing skeletal muscles in the mouse embryo and some recent findings that have established skeletal myogenesis as an important paradigm for studying the restriction of cell fate during embryonic, fetal and postnatal development. Other aspects of myogenesis have been reviewed extensively in recent years, and the reader is invited to refer to them for more detailed information on the subject (Ordahl 2000 and references therein).

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Authors and Affiliations

  1. Department of Developmental Stem Cells & Development Biology, Pasteur Institute, 25 rue du Dr. Roux, 75724, Paris, Cedex 15, France

    Shahragim Tajbakhsh

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  1. Shahragim Tajbakhsh
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Editors and Affiliations

  1. Institute of Anatomy II, Albert Ludwigs University Freiburg, Albertstraße 17, 79104, Freiburg, Germany

    Beate Brand-Saberi

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Tajbakhsh, S. (2002). The Genetics of Murine Skeletal Muscle Biogenesis. In: Brand-Saberi, B. (eds) Vertebrate Myogenesis. Results and Problems in Cell Differentiation, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45686-5_3

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  • DOI: https://doi.org/10.1007/978-3-540-45686-5_3

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