Abstract
With the awareness of the importance of the bone architecture to the overall stability of bone, micro-CT has become the gold standard for 3D static histomorphometry in bone research over the past 10 years. Nevertheless, bone densitometry is still the method of choice in the clinical environment. It is, however, anticipated that only a combination of the two methods, densitometry and morphometry, will improve the diagnosis and treatment of patients. This chapter introduces the calibration of micro-CT for quantification of bone mineral and material density at both organ and tissue levels and its impact in bone and mineral research based on bone biopsy. This approach may also be widely applied to measure the density of other appreciated materials.
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References
Gong H, Zhang M, Yeung HY, Qin L (2005) Regional variations in microstructural properties of vertebral trabeculae with ageing. J Bone Miner Metabol 23:174–180
Hildebrand T, Laib A (1999) Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 14:1167–1174
Hildebrand T, Rüegsegger P (1997a) A new method for the model independent assessment of thickness in three-dimensional images. J Microsc 185:67–75
Hildebrand T, Rüegsegger P (1997b) Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomel Eng 1:15–23
Lai YM, Qin L, Hung VWY, Chan KM (2005a) Regional differences in cortical bone mineral density in weight-bearing long bone shaft: a pQCT study. Bone 36:467–471
Lai YM, Qin L, Yeung HY, Lee KM, Chan KM (2005b) Regional differences in trabecular BMD and microarchitecture of weight bearing bone under habitual gait loading: a pQCT and micro-CT study in human subject. Bone 37:274–282
Laib A, Newitt DC, Lu Y, Majumdar S (2002) New model-independent measures of trabecular bone structure applied to in vivo high-resolution MR images. Osteoporosis Int 13:130–136
Lorensen WE, Cline HE (1987) Marching cubes: a high resolution 3D surface construction algorithm. Comput Graphics 21:163–169
Odgaard A, Gundersen HJG (1993) Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstruction. Bone 14:173–182
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© 2007 Springer-Verlag Berlin Heidelberg
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Koller, B., Laib, A. (2007). Calibration of Micro-CT Data for Quantifying Bone Mineral and Biomaterial Density and Microarchitecture. In: Qin, L., Genant, H.K., Griffith, J.F., Leung, K.S. (eds) Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45456-4_5
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DOI: https://doi.org/10.1007/978-3-540-45456-4_5
Publisher Name: Springer, Berlin, Heidelberg
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