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Bio-imaging Technologies in Studying Bone-Biomaterial Interface: Applications in Experimental Spinal Fusion Model

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Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials

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Abstract

Spinal fusion in orthopedic surgery is commonly used to treat spinal deformity and degenerative diseases such as scoliosis and degenerative disc disease. To advance surgical and outcome efficacy and study the biological regulations, different animal models of spinal fusion have been established, including rats, rabbits, dogs, sheep, goats, and even non-human primates. With novel biological factors, biomaterials, biophysical devices and gene therapy, and stem-cell-based-therapy being developed, many medical imaging assessment techniques are being adopted further to evaluate their potential in facilitating spinal fusion experimentally before clinical application. Many bio-imaging evaluation technologies have been developed and their potential has been explored in evaluation of bone and biomaterial interface integration both preclinically and clinically. This chapter reviews some of the conventional and advanced techniques being applied for evaluation of rate and quality of spinal fusion, especially the experimental spinal fusion models based on our own studies. These techniques are summarized in the following categories in studying fusion complex or materials properties: (a) low resolution X-ray; quantitative CT, MRI, and clinical densitometry; (b) high-resolution micro-CT, 2D and 3D histomorphometry with both static and dynamic indices; and (c) macro- and microbiomechanical tests. The general advantages and limitations of the technologies are also briefly summarized. This overview might serve as a reference for future studies concerning study design and selection of technologies for qualitative and quantitative evaluation of spinal fusion based on availability of these methods and potential local and international collaborations.

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Authors and Affiliations

  1. Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China

    Chun Wai Chan, Jack Chun-Yiu Cheng, Hiu-Yan Yeung & Ling Qin

Authors
  1. Chun Wai Chan
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  2. Jack Chun-Yiu Cheng
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  3. Hiu-Yan Yeung
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  4. Ling Qin
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Corresponding author

Correspondence to Chun Wai Chan .

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Editors and Affiliations

  1. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China

    Ling Qin (Professor) & Kwok Sui Leung (Professor of Department of Orthopaedics & Traumatology) (Professor) &  (Professor of Department of Orthopaedics & Traumatology)

  2. University of California, San Francisco

    Harry K. Genant (Professor Emeritus, Chairman Emeritus and Board of Directors) (Professor Emeritus, Chairman Emeritus and Board of Directors)

  3. Synarc, Inc, USA

    Harry K. Genant (Professor Emeritus, Chairman Emeritus and Board of Directors) (Professor Emeritus, Chairman Emeritus and Board of Directors)

  4. Department of Radiology and Organ Imaging, The Chinese University of Hong Kong, Hong Kong SAR, China

    James F. Griffith

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© 2007 Springer-Verlag Berlin Heidelberg

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Chan, C.W., Cheng, J.CY., Yeung, HY., Qin, L. (2007). Bio-imaging Technologies in Studying Bone-Biomaterial Interface: Applications in Experimental Spinal Fusion Model. In: Qin, L., Genant, H.K., Griffith, J.F., Leung, K.S. (eds) Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45456-4_20

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  • DOI: https://doi.org/10.1007/978-3-540-45456-4_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-45454-0

  • Online ISBN: 978-3-540-45456-4

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