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Developmental Regulation Through Protein Stability

  • Chapter
Drosophila Eye Development

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 37))

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Abstract

The idea that differential gene expression is critical to the establishment of different cell identities is well-worn into the psyches of all scientists who think about the cellular dynamics of development. Equally commonplace is the idea that temporally and spatially dynamic gene expression is quite often regulated at the level of transcription initiation. More exotic forms of regulation are also well-known, including mRNA splicing, mRNA and protein localization, protein-protein interactions and protein modification. Most recently, it has become apparent that specific alteration of protein stability is a widely used mechanism for controlling the dynamics of important cellular regulators. For example, the levels of cyclins and transcription factors are controlled by specifically targeted protein degradation via the ubiquitin/proteasome pathway.

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Authors and Affiliations

  1. Section of Molecular Cell and Developmental Biology, The Institute for Cellular and Molecular Biology, Moffett Molecular Biology Building, The University of Texas at Austin, 2500 Speedway, Austin, Texas, 78712, USA

    Janice A. Fischer

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  1. Department of Cell Biology, Emory University School of Medicine, 1648 Pierce Drive NE, 30322-3030, Atlanta, Ga, USA

    Kevin Moses

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© 2002 Springer-Verlag Berlin Heidelberg

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Fischer, J.A. (2002). Developmental Regulation Through Protein Stability. In: Moses, K. (eds) Drosophila Eye Development. Results and Problems in Cell Differentiation, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45398-7_10

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  • DOI: https://doi.org/10.1007/978-3-540-45398-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-53640-3

  • Online ISBN: 978-3-540-45398-7

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