Abstract
A new method to derive a score function to detect remote relationships between protein sequences has been developed. The new score function, OPTIMA, was obtained after maximization of a function of merit representing a measure of success in recognizing homologs of the newly sequenced protein among thousands of non-homolog sequences in the databases. We find that the new score function obtained in such a manner performs better than standard score functions for the identification of distant homologies.
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Kann, M., Goldstein, R.A. (2003). OPTIMA: A New Score Function for the Detection of Remote Homologs. In: Guerra, C., Istrail, S. (eds) Mathematical Methods for Protein Structure Analysis and Design. Lecture Notes in Computer Science(), vol 2666. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-44827-3_5
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DOI: https://doi.org/10.1007/978-3-540-44827-3_5
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