Abstract
The Tor (target of rapamycin) signaling pathway is an important mechanism used by eukaryotic cells to regulate their growth in response to nutrient-related environmental cues. Recent studies have revealed that the two Tor kinases in S. cerevisiae, Tor1p and Tor2p, regulate gene expression at several levels, including transcription, translation, intracellular protein trafficking, as well as protein stability. How the activity of each kinase is controlled remains to be elucidated, however, as does the nature of potential upstream regulatory signals. Here we review recent efforts to address these issues by focusing on two areas related to Tor signaling: (1) transcriptional control of genes required for the de novo biosynthesis of glutamate and glutamine and (2) characterization of interacting partners of Tor1p and Tor2p. These studies have converged in unanticipated ways to yield new insights into how these kinases may function both to receive as well as transmit nutritional information in yeast.
Keywords
- General Amino Acid Permease
- Intracellular Protein Trafficking
- Cell Integrity Pathway
- Tryptophan Permease
- MKS1 Gene
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2004 Springer-Verlag Berlin/Heidelberg
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Powers, T., Chen, CY., Dilova, I., Reinke, A., Wedaman, K.P. (2004). 8 Tor-signaling and Tor-interacting proteins in yeast. In: Winderickx, J.G., Taylor, P.M. (eds) Nutrient-Induced Responses in Eukaryotic Cells. Topics in Current Genetics, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-39898-1_9
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DOI: https://doi.org/10.1007/978-3-540-39898-1_9
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Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-540-39898-1
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