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Optimal DNA Signal Recognition Models with a Fixed Amount of Intrasignal Dependency

  • Broňa Brejová
  • Daniel G. Brown
  • Tomáš Vinař
Part of the Lecture Notes in Computer Science book series (LNCS, volume 2812)

Abstract

We study new probabilistic models for signals in DNA. Our models allow dependencies between multiple non-adjacent positions, in a generative model we call a higher-order tree. Computing the model of maximum likelihood is equivalent in our context to computing a minimum directed spanning hypergraph, a problem we show is NP-complete. We instead compute good models using simple greedy heuristics. In practice, the advantage of using our models over more standard models based on adjacent positions is modest. However, there is a notable improvement in the estimation of the probability that a given position is a signal, which is useful in the context of probabilistic gene finding. We also show that there is little improvement by incorporating multiple signals involved in gene structure into a composite signal model in our framework, though again this gives better estimation of the probability that a site is an acceptor site signal.

Keywords

Optimal Topology Directed Acyclic Graph Acceptor Site Donor Splice Site Position Weight Matrix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Broňa Brejová
    • 1
  • Daniel G. Brown
    • 1
  • Tomáš Vinař
    • 1
  1. 1.School of Computer ScienceUniversity of WaterlooWaterlooCanada

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