Abstract
Bilirubin (BR) which is known to bind strongly to human serum albumin (HSA) (1,2,3) and to lipids, lipoproteins and cell membranes (4,5) can be considered, in the body to be distributed according to the equilibrium:
The high BR level in infants suffering from neonatal jaundice exposes them to the risk of kernicterus in which irreversible tissue damage results from the uptake of BR by brain cells (6). Although phototherapy, in recent years, has proved extremely effective in the reduction of BR levels in jaundiced infants, the precise mechanism for this process is still not fully understood and has provoked much photochemical study (7). One interpretation postulates self sensitised photooxidation (8) and another proposes photoisomerisation (9,10) of BR.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ostrow, J.D. and R. Schmid, J. Clin. Invest. (1963), 42, 1286.
Beaven, G.H., A. d’Albis and W. Gratzer, Eur. J. Biochem, (1973), 33, 500.
Chen, R.F., in “Biological Fluorescence Concepts”, ed. A.A. Thaer and M. Sernetz, Springer Verlag (1973), 273.
Mustafa, M.G. and T.E. King, J. Biolo Chem. (l910), 245, 1084.
Cowger, Marilyn L., in “Phototherapy of the Newborn — an overview”, ed. G.B. Odell, R. Schaffer and A.P. Simopoulos, Nat. Acado Sci. U.S.A. (1974), 93.
Diamond, I., in Adv. Pediatr., ed. I. Schulman, Chicago Year Book Medical Publishers (1969), 16, 99.
Lightner, D.A., Photochem. Photobiol. (1977), 26, 427.
McDonagh, A.F., in “Bilirubin Metabolism in the Newborn”, ed. D. Bergsma and S.H. Blondheim, National Foundation March of Dimes (1976), 40.
Lightner, D.A. and Y.T. Park, Tetrahedron Lett. (1976) 2209,
McDonagh, A.F., D.A. Lightner and T.A. Wooldridge, J.C.S., Chem. Commun. (1979) 110.
Land, E.J., Photochem, Photobiolo (1976), 24, 475.
McVie, J., R.S. Sinclair and T.G. Truscott, J.C.S., Faraday II (1978), 74, 187O0
Richards, J.T. and J.K. Thomas, Trans. Faraday Soc. (1970), 66, 621.
Bensasson, R.V., C.R. Goldschmidt, E.J. Land and T.G. Truscott, Photochem. Photobiol. (1978), 28, 277.
Birks, J.B., ed. “Organic Molecular Photophysics” Vol.1, John Wiley, 1973.
Birks, J.B., ed. “Organic Molecular Photophysics” Vol.II, John Wiley, 1974.
Barber, D. J. Wo and J. T. Richards, Chem. Phys. Lett. (1977), 46, 130.
Krasner, J. and S.J. Yaffe, in “Bilirubin Metabolism in the Newborn II”, edo D. Bergsma and S.H. Blondheim, National Foundation March of Dimes (1976), 1680
Kuenzle, C.C., N. Cumarasamy and K. Wilson, in “Metabolism and Chemistry of Bilirubin and Related Tetrapyrolles”, edo A.F. Bakken and J. Fog, Pediatr, Res. Inst., Rikshospitalet, Oslow (1975), 39.
Manitto, P. and D. Monti, JoC.S., Chem. Commun. (1976), 122.
Falk, H., K. Grubmayr and T. Schlederer, Monatshefte für Chemie (1978), 109, 1191.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Sinclair, R.S., Sloper, R.W., Truscott, T.G. (1980). A Laser Flash Photolysis Study of Bilirubin. In: Pratesi, R., Sacchi, C.A. (eds) Lasers in Photomedicine and Photobiology. Springer Series in Optical Sciences, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38270-6_20
Download citation
DOI: https://doi.org/10.1007/978-3-540-38270-6_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-13499-3
Online ISBN: 978-3-540-38270-6
eBook Packages: Springer Book Archive