Abstract
Since the relevant data obtained in studies of teratomas have been extensively reviewed (Pierce 1967; Stevens 1967; Damjanov and Solter 1974; Martin 1975; Solter et al. 1975; Jacob 1978), it is unnecessary to mention numerous original papers describing the advantage of this model system for various studies of embryogenesis and neoplasia. Experimental teratomas derived from mouse embryonic shields emphasize the close relationship between early embryo cells and tumor stem cells which can give rise either to embryonal carcinoma cells or to various differentiated cell types. The individual embryonal carcinoma cells probably have the full range of developmental potentialities, but at present it is impossible to single out those factors indispensable for teratocarcinogenesis or those indispensable for differentiation (Illmensee and Mintz 1976).
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Škreb, N., Crnek, V. (1980). Development of Embryo-Derived Teratomas in Vitro. In: McKinnell, R.G., DiBerardino, M.A., Blumenfeld, M., Bergad, R.D. (eds) Differentiation and Neoplasia. Results and Problems in Cell Differentiation, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38267-6_36
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DOI: https://doi.org/10.1007/978-3-540-38267-6_36
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