Abstract
The experimental modification of the genome of a mammalian cell might be envisaged by the following two microsurgical approaches: (1) the removal of genetic information and its phenotypic consequences to differentiation, and (2) the addition of genetic material and its expression during development and neoplasia. During the past few years, both approaches have been realized in the mouse, the most suitable mammalian organism for genetic studies, and I should like briefly to summarize these new results, discuss their relevance and applicability to experimental embryology and cancer research and finally remark upon some promising prospects in genetic manipulation of the mammalian embryo.
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Illmensee, K. (1980). Genetic Manipulation of the Early Mouse Embryo. In: McKinnell, R.G., DiBerardino, M.A., Blumenfeld, M., Bergad, R.D. (eds) Differentiation and Neoplasia. Results and Problems in Cell Differentiation, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38267-6_10
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DOI: https://doi.org/10.1007/978-3-540-38267-6_10
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