Skip to main content

Prevention of Hepatocellular Carcinoma in Chronic Viral Hepatitis Patients with Cirrhosis by Carotenoid Mixture

  • Conference paper

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 174))

Abstract

Since the incidence of hepatocellular carcinoma in chronic viral hepatitis patients with cirrhosis is very high, it is valuable to develop effective methods for its prevention. In the present study, the effect of a carotenoid mixture on hepatocellular carcinoma development was examined. Patients were randomly divided into two groups and treated with a carotenoid mixture in addition to conventional antisymptomatic treatment, or antisymptomatic treatment alone. Cumulative incidence of hepatocellular carcinoma development was periodically analyzed using the Kaplan-Meier method. Significantly lower incidence was observed in the carotenoid-treated group compared with the control group in the analysis at year 4.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Jinno K, Tanimizu M, Ishikawa H, Nishino H, Sakamoto H, Ohshima T (1997) Interventional trial for prevention of hepatocellular carcinoma. J Clin Sci 33:952–963

    Google Scholar 

  • Murakoshi M, Nishino H, Satomi Y, Takayasu J, Hasegawa T, Tokuda H, Iwashima A, Okuzumi J, Okabe H, Kitano H, Iwasaki R (1992) Potent preventive action of α-carotene against carcinogenesis: Spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by α-carotene than β-carotene. Cancer Res 52:6583–6587

    PubMed  CAS  Google Scholar 

  • Nishino H (1997) Cancer prevention by natural carotenoids. J Cell Biochem 27:86–91

    Article  CAS  Google Scholar 

  • Nishino H, Murakoshi M, Masuda M, Tokuda H, Satomi Y, Onozuka M, Yamaguchi S, Bu P, Tsuruta A, Nosaka K, Baba M, Takasuka N (1999) Suppression of lung and liver carcinogenesis in mice by oral administration of myo-inosito. Anticancer Res 19:3663–3664

    PubMed  CAS  Google Scholar 

  • Oka H, Yamamoto S, Kuroki T, Harihara S, Marumo T, Kim SR, Monna T, Kobayashi K, Tango T (1995) Prospective study of chemoprevention of hepatocellular carcinoma with Sho-saiko-to (TJ-9). Cancer 76:743–749

    Article  PubMed  CAS  Google Scholar 

  • Tsuda H, Iwahori Y, Hori T, Asamoto M, Baba-Toriyama H, Kim DJ, Kim JM, Uehara N, Iigo M, Takasuka N, Murakoshi M, Nishino H, Kakizoe T (1997) Chemopreventive potential of α-carotene against mouse liver and lung tumor development: Comparison with β-carotene and α-tocopherol. In: Ohigashi H, Osawa T, Terao J, Watanabe S, Yoshikawa T (eds) Food factors for cancer prevention. Springer-Verlag, Tokyo, pp 529–532

    Google Scholar 

  • Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H (2005) Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett 229:181–191

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Nishino, H. (2007). Prevention of Hepatocellular Carcinoma in Chronic Viral Hepatitis Patients with Cirrhosis by Carotenoid Mixture. In: Senn, HJ., Kapp, U. (eds) Cancer Prevention. Recent Results in Cancer Research, vol 174. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37696-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-37696-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-37695-8

  • Online ISBN: 978-3-540-37696-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics