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Thorakale Neoplasien

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Klinische Pneumologie

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Unter den thorakalen Neoplasien werden die Neoplasien der Lungen und Bronchien, des Mediastinums und der Pleura zusammengefasst. Tumoren des Ösophagus und des Herzens werden primär nicht darunter gerechnet. Die Symptomatik ist sehr unterschiedlich und hängt — abgesehen von paraneoplastischen Symptomen — vor allem von der anatomischen Lokalisation und der Beeinträchtigung von relevanten anatomischen Strukturen ab. Symptome, die eine Früherkennung ermöglichen, sind sehr selten. Teilweise sind sehr große Tumoren ohne Symptome, oft werden die malignen Tumoren erst im metastasierten Stadium diagnostiziert.

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Literatur

  • American College of Chest Physicians (2003) Lung Cancer Guidelines. Chest 123(1), supplement: 1S–337S

    Article  Google Scholar 

  • ACCP (2007) Evidence-Based Clinical Practice Guidelines (2nd Edition) Chest 132:1S–422S

    Article  Google Scholar 

  • Blome O (2005) Berufskrankheiten-Merkblätter, Textausgabe — Rechtsgrundlagen-Hinweise — Unfallversicherungsanzeigen — Verordnung — Berufskrankheiten in Europa, 4. Aufl. Düringshofen, Berlin

    Google Scholar 

  • Bolliger C, Perruchoud A (1998): Functional evaluation of the lung resection candidate. Eur Respir J 11:198–212

    Article  PubMed  CAS  Google Scholar 

  • Bolliger CT, Sutedja TG, Strausz J, Freitag L. (2006) Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents. Eur Respir J 27:1258–1271

    Article  PubMed  CAS  Google Scholar 

  • Boyle P, Ferlay J (2005) Cancer incidence and mortality in Europe, 2004. Ann Oncol 16:481–488

    Article  PubMed  CAS  Google Scholar 

  • Hanna N et al. (2004) Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non-Small-Cell Lung Cancer Previously Treated With Chemotherapy. J Clin Oncol 22:1589–1597

    Article  PubMed  CAS  Google Scholar 

  • Huber RM (Hrsg.) (2006) Manual Tumorzentrum München. Tumoren der Lunge und des Mediastinums. Zuckschwerdt, München. Online über: http://tzm.web.med.uni-muenchen.de

    Google Scholar 

  • Huber RM et al. (2006) Simultaneous Chemoradiotherapy Compared With Radiotherapy Alone After Induction Chemotherapy in Inoperable Stage IIIA or IIIB Non-Small-Cell Lung Cancer: Study CTRT99/97 by the Bronchial Carcinoma Therapy Group. J Clin Oncol 24:4397–4404

    Article  PubMed  CAS  Google Scholar 

  • International Agency for Research on Cancer (IARC) (2002) Tobacco smoke and involuntary smoking. IARC Monogrs, Vol 83

    Google Scholar 

  • Kelly K, Crowley J, Bunn Jr PA et al. (2001) Randomized Phase III Trial of Paclitaxel Plus Carboplatin Versus Vinorelbine Plus Cisplatin in the Treatment of Patients With Advanced Non-Small-Cell Lung Cancer: A Southwest Oncology Group Trial. J Clin Oncol 19:3210–3218

    PubMed  CAS  Google Scholar 

  • Manser RL, Irving LB, Byrnes G, Abramson MJ, Stone CA, Campbell DA (2003) Screening for lung cancer: a systematic review and meta-analysis of controlled trials. Thorax 58:784–789

    Article  PubMed  CAS  Google Scholar 

  • Mountain CF (1997) Revision in the international system for staging lung cancer. Chest 111: 710–1717

    Google Scholar 

  • Non-small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Br Med J 311:899–909

    Google Scholar 

  • National Collaborating Centre for Acute Care (2005) Diagnosis and treatment of lung cancer. National Collaborating Centre for Acute Care, London. www.rcseng.ac.uk

    Google Scholar 

  • Pfister D, Johnson D, Azzoli C, Sause W, Smith T, Baker S, Olag J, Stover D, Strawn J, Turrisi A, Somerfield M (2004) American Society of Clinical Oncology treatment of unresectable non-small cell lung cancer guideline: Update 2003. J Clin Oncol 22:330–353

    Article  PubMed  Google Scholar 

  • Pisters KMW and Le Chevalier T (2005) Adjuvant Chemotherapy in Completely Resected Non-Small-Cell Lung Cancer. J Clin Oncol 23:3270–3278

    Article  PubMed  CAS  Google Scholar 

  • Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J, Johnson DH for the Eastern Cooperative Oncology Group (2002) Comparison of Four Chemotherapy Regimens for Advanced Non-Small-Cell Lung Cancer. N Engl J Med 346:92–98

    Article  PubMed  CAS  Google Scholar 

  • Shepherd FA et al. (2000) Prospective Randomized Trial of Docetaxel Versus Best Supportive Care in Patients With Non-Small-Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy. J Clin Oncol 18:2095–2103

    PubMed  CAS  Google Scholar 

  • Shepherd FA et al. (2005) Erlotinib in Previously Treated Non-Small-Cell Lung Cancer. N Engl J Med 353:123–132

    Article  PubMed  CAS  Google Scholar 

  • Simonato L, Agudo A, Ahrens W et al. (2001) Lung cancer and cigarette smoking in Europe: an update of risk estimates and an assessment of inter-country heterogeneity. Int J Cancer 91:876–887

    Article  PubMed  CAS  Google Scholar 

  • Travis WD, Brambilla E, Müller-Hermelink, HK and Harris CC (eds.) (2004) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press, Lyon

    Google Scholar 

  • Vergnon J-M, Huber RM, Moghissi K (2006) Place of cryotherapy, brachytherapy and photodynamic therapy in therapeutic bronchoscopy of lung cancers. Eur Respir J 28:200–218

    Article  PubMed  Google Scholar 

  • Winton TL, Livingston R, Johnson D et al. (2005). A prospective randomized trial of adjuvant vinorelbine and cisplatin in completely resected stage IB and II non-small-cell lung cancer. Intergroup JBR.10. N Engl J Med 352:2589–97

    CAS  Google Scholar 

  • Wittekind Ch, Meyer HJ, Bootz F (Hrsg) (2002) UICC TNM-Klassifikation maligner Tumoren. Springer, Berlin Heidelberg New York

    Google Scholar 

Literatur

  • Albers E, Lawrie T, Harrell JH, Yi ES (2004) Tracheobronchial Adenoid Cystic Carcinoma. A Clinicopathologic Study of 14 cases. Chest 125:1160–1165

    Article  PubMed  Google Scholar 

  • Bajetta E, Ferrari L, Martinetti A et al. (1999) Chromogranin A, Neuron specific enolase, carcinoembryonic antigen, and hydroxyindol acetic acid evaluation in patients with neuroendocrine tumors. Cancer 86:858–865

    Article  PubMed  CAS  Google Scholar 

  • Cimitian M, Buonadonna A, Cannizarro R et al. (2003) Somatostatin receptor scintigraphy versus Chromogranin A assay in the management of patients with neuroendocrine tumors of different types: clinical role. Ann Oncol 14:1135–1141

    Article  Google Scholar 

  • Daddi N, Ferolla P, Urbani M et al. (2004) Surgical treatment of neuroendocrine tumors of the lung. Eur J Cardiothor Surg 26:813–817

    Article  Google Scholar 

  • Filosso PL, Ruffini E, Oliaro A et al. (2002) Longterm survival of atypical bronchial carcinoids with liver metastases, treated with octreotide. Eur J Cardiothoracic Surg 21:913–917

    Article  Google Scholar 

  • García-Yuste M, Matilla JM, Alvarez-Gago T et al. (2000) Prognostic factors in neuroendocrine lung tumors: a Spanish multicenter study. Ann Thorac Surg 70:258–263

    Article  PubMed  Google Scholar 

  • Granberg D, Eriksson B, Wilander E et al. (2001) Experience in treatment of metastatic pulmonary carcinoid tumors. Ann Oncol 12:1383–1391

    Article  PubMed  CAS  Google Scholar 

  • Hage R, Brutel de la Rivière A, Seldenrijk CA et al. (2003) Update in pulmonary carcinoid tumors: a review article. Ann Surg Oncol 10(6):697–704

    Article  PubMed  CAS  Google Scholar 

  • Huber RM (Hrsg.) (2006) Manual Tumorzentrum München. Tumoren der Lunge und des Mediastinums. Zuckschwerdt, München. Online über: http://tzm.web.med.uni-muenchen.de

    Google Scholar 

  • Kaplan B, Stevens CW, Allen P, Liao Z, Komaki R. (2003) Outcomes and patterns of failure in bronchial carcinoid tumors. Int J Radiat Oncol Biol Phys 55:125–131

    Article  PubMed  Google Scholar 

  • Kwak SH, Lee KS, Chung MJ, Jeong YJ, Kim GY, Kwon OJ (2004) Adenoid cystic carcinoma of the airways: helical CT and histopathologic correlation. Am J Roentgenol 183(2):277–281

    Google Scholar 

  • Maziak DE, Todd TRJ, Keshavjee SH, Winton TL, Van Nostrand P, Pearson FG (1996) Adenoid cystic carcinoma of the airway: thirty-two-year experience. J Thorac Cardiovasc Surg 112:1522–1532

    Article  PubMed  CAS  Google Scholar 

  • Mezzetti M, Raveglia F, Panigalli T et al. (2003) Assessment of outcomes in typical and atypical carcinoids according to latest WHO classification. Ann Thorac Surg 76:1838–1842

    Article  PubMed  Google Scholar 

  • Regnard JF, Fourquier P, Levasseur P (1996) Results and prognostic factors in resections of primary tracheal tumors: a multicenter retrospective study. The French Society of Cardiovascular Surgery. J Thorac Cardiovasc Surg 111(4):808–813; discussion 813–814

    Article  PubMed  CAS  Google Scholar 

  • Travis WD, Brambilla E, Müller-Hermelink, HK, Harris CC (eds.) (2004) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon

    Google Scholar 

  • Wirth LJ, Carter MR, Jänne PA, Johnson BE (2004) Outcome of patients with pulmonary carcinoid tumors receiving chemotherapy or chemoradiotherapy. Lung Cancer 44:213–220

    Article  PubMed  Google Scholar 

Literatur

  • Friedel G, Pastorino U, Ginsberg RJ, Goldstraw P, Johnston M, Pass H, Putnam JB, Toomes H (2002) Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases. Eur J Cardiothorac Surg 22(3):335–344

    Article  PubMed  Google Scholar 

  • van Geel AN, Pastorino U, Jauch KW, Judson IR, van Coevorden F, Buesa JM, Nielsen OS, Boudinet A, Tursz T, Schmitz PI (1996) Surgical treatment of lung metastases: The European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group study of 255 patients. Cancer 77(4): 675–682

    Article  PubMed  Google Scholar 

  • Huber RM (Hrsg.) (2006) Manual Tumorzentrum München. Tumoren der Lunge und des Mediastinums. Zuckschwerdt, München. Online über: http://tzm.web.med.uni-muenchen.de

    Google Scholar 

  • Leo F, Cagini L, Rocmans P, Cappello M, Geel AN, Maggi G, Goldstraw P, Pastorino U (2000) Lung metastases from melanoma: when is surgical treatment warranted? Br J Cancer 83(5):569–572

    Article  PubMed  CAS  Google Scholar 

  • Pfannschmidt J, Muley T, Hoffmann H, Dienemann H (2003) Prognostic factors and survival after complete resection of pulmonary metastases from colorectal carcinoma: experiences in 167 patients. J Thorac Cardiovasc Surg 126(3):732–739

    Article  PubMed  Google Scholar 

  • Piltz S, Meimarakis G, Wichmann MW, Hatz R, Schildberg FW, Fuerst H (2002) Long-term results after pulmonary resection of renal cell carcinoma metastases. Ann Thorac Surg 73(4):1082–1087

    Article  PubMed  Google Scholar 

Literatur

  • Manser RL, Irving LB, Byrnes G, Abramson MJ, Stone CA, Campbell DA (2003) Screening for lung cancer: a systematic review and metaanalysis of controlled trials. Thorax 58:784–789

    Article  PubMed  CAS  Google Scholar 

  • Suzuki N, Ohno S, Ishii Y, Kitamura S (1994) Peripheral intrapulmonary hamartoma accompanied by a similar endotracheal lesion. Chest 106:1291

    Article  PubMed  CAS  Google Scholar 

  • Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC (eds.) (2004) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon

    Google Scholar 

  • van den Bosch JM, Wagenaar SS, Corrin B, Elbers JR, Knaepen PJ, and Westermann CJ (1987) Mesenchymoma of the lung (so called hamartoma): a review of 154 parenchymal and endobronchial cases Thorax 42:790

    Article  PubMed  Google Scholar 

Literatur

  • England DM, Hochholzer L, McCarthy MJ (1989) Localized benign and malignant fibrous tumors of the pleura. A clinicopathologic review of 223 cases. Am J Surg Pathol 13:640–658

    PubMed  CAS  Google Scholar 

  • Huber RM (Hrsg.) (2006) Manual Tumorzentrum München. Tumoren der Lunge und des Mediastinums. Zuckschwerdt, München. Online über: http://tzm.web.med.uni-muenchen.de

    Google Scholar 

  • Pass HI, Lott D, Lonardo F, Harbut M, Liu Z, Tang N, Carbone M, Webb C, Wali A (2005) Asbestos Exposure, Pleural Mesothelioma, and Serum Osteopontin Levels. N Engl J Med;353:1564–1573

    Article  PubMed  CAS  Google Scholar 

  • Robinson BWS, Creaney J, Lake RA et al. (2003) Mesothelin-family proteins and diagnosis of mesothelioma. Lancet 362:1612–1616

    Article  PubMed  CAS  Google Scholar 

  • Rusch VW (1996) A proposed new international TNM staging system for malignant pleural Mesothelioma from the International Mesothelioma Interest Group. Lung Cancer 14:1–12

    Article  PubMed  CAS  Google Scholar 

  • Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC (eds.) (2004) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon

    Google Scholar 

  • van Meerbeeck JP, Gaafar R, Manegold C et al. (2005) Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma: An Intergroup Study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. J Clin Oncol 23:6881–6889

    Article  PubMed  CAS  Google Scholar 

  • Vogelzang NJ, Rusthoven JJ, Symanowski J et al. (2003) Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma. J Clin Oncol 21:2636–2644

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Davis RD Jr, Newland Oldham H Jr, Sabiston DC Jr (1987) Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management and results. Ann Thorac Surg 44:229–237

    Article  PubMed  Google Scholar 

  • Dulmet EM, Macchiarini P, Suc B, Verley JM (1993) Germ cell tumours of the mediastinum. A 30-year experience. Cancer 72:1894–1901

    Article  PubMed  CAS  Google Scholar 

  • Duwe BV, Sterman DH, Musani AI (2005) Tumors of the Mediastinum. Chest 128:2893–2909

    Article  PubMed  Google Scholar 

  • Huber RM (Hrsg.) (2006) Manual Tumorzentrum München. Tumoren der Lunge und des Mediastinums. Zuckschwerdt, München. Online über: http://tzm.web.med.uni-muenchen.de

    Google Scholar 

  • Emmerich L (Hrsg) (2000) Manual Tumorzentrum München. Maligne Lymphome, Empfehlungen zur Diagnostik, Therapie und Nachsorge, 6. Aufl. Zuckschwerdt, München. Online über: http://tzm.web.med.uni-muenchen.de

    Google Scholar 

  • Lamy AL, Fradet GJ, Luoma A, Nelems B (1994) Anterior and middle mediastinum paraganglioma: complete resection is the treatment of choice. Ann Thorac Surg 57:249–252

    PubMed  CAS  Google Scholar 

  • Marchevsky AM, Kaneko M (1992) Surgical pathology of the mediastinum, 2nd ed. Raven Press, New York

    Google Scholar 

  • Masaoka A, Monden Y, Nakahana K, Tanioka T (1981) Follow-up study of thymomas with special reference to their clinical stages. Cancer 48:2485–2492

    Article  PubMed  CAS  Google Scholar 

  • Moran CA, Suster S, Fishback N, Koss MN (1993) Mediastinal paragangliomas. A clinicopathologic and immunohistochemical study of 16 cases. Cancer 72:2358–2364

    Article  PubMed  CAS  Google Scholar 

  • Rosai J, Sobin LH (1999) Histological typing of tumours of the thymus. WHO International Histological classification of tumours, 2nd ed. Springer, Heidelberg

    Google Scholar 

  • Saenz NC, Schnitzer JJ, Eraklis AE, Hendren WH, Grier HE, Macklis RM, Shamberger RC (1993) Posterior mediastinal masses. J Pediatr Surg 28:172–176

    Article  PubMed  CAS  Google Scholar 

  • Shimosato Y, Mukai K (1997) Tumors of the mediastinum. In: Atlas of tumor pathology, Series 3, Fascicle 21. Washington DC, Armed Forces Institute of Pathology

    Google Scholar 

  • Travis WD, Brambilla E, Müller-Hermelink, HK and Harris CC (eds.) (2004) World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. IARC Press: Lyon

    Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik Innenstadt Fachbereich Pneumologie, Klinikum der Universität München, Ziemssenstr. 1, 80336, München

    Prof. Dr. med. R. M. Huber

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  1. Prof. Dr. med. R. M. Huber
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  1. Hochrüttestraße 17, 79117, Freiburg i. Br.

    Heinrich Matthys

  2. Medizinische Klinik II, Justus-Liebig-Universität Gießen, Klinikstraße 36, 35392, Gießen

    W. Seeger

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Huber, R.M. (2008). Thorakale Neoplasien. In: Matthys, H., Seeger, W. (eds) Klinische Pneumologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37692-7_10

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