Abstract
The molecular machinery for the ordered unfolding of genetic potential, within the cell cycle, exists even in the simplest cells we know, the prokaryotes. Although all bacteria regulate their growth rate and assembly of internal structures, these events are difficult to study because they represent an organizational level too small to be resolved by traditional cytological methods and, until recently, too complex to dissect by purely biochemical methods. An example of such a multimolecular process is the replication of DNA in E. coli, which is now known to involve several protein components (Gefter et al, 1971; SScheckman et al., 1972; Wickner et al., 1972), probably occurs attached to the inside surface of the membrane (Ryter, 1968) and is expressed as a defined time function of the cell cycle (Donachie et al., 1973). Clearly, it would be advantageous to investigate a unicellular bacterium that undergoes gross morphological and biosynthetic changes during the cell cycle, so that events taking place within the cell can be conveniently monitored.
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Wood, N.B., Shapiro, L. (1975). Morphogenesis during the Cell Cycle of the Prokaryote, Caulobacter crescentus. In: Reinert, J., Holtzer, H. (eds) Cell Cycle and Cell Differentiation. Results and Problems in Cell Differentiation, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37390-2_8
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DOI: https://doi.org/10.1007/978-3-540-37390-2_8
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