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Neurogenesis and the Cell Cycle

  • Chapter
Cell Cycle and Cell Differentiation

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 7))

Abstract

Despite the complexity of structure and function in the adult central nervous system, neurogenesis occurs in a fashion relatively parallel to other developing cell systems, with proliferation of cells taking place in an orderly programmed fashion. The complexity of the nervous system apparently derives from genetic and environmental influences which not only direct proliferation of the various cell types, but also control subsequent cell migrations, local overgrowth, selective cell death, differentiation of the various cell types, and the establishment of functionally appropriate connections between cells. This account is limited to the earlier stages of neurogenesis and the relationship of the cell cycle to the proliferation and differentiation of the various cell types. The excellent reviews of Jacobson (1970), Gaze (1970), Angevine (1970), Sidman (1970), and Watterson (1965) should be consulted for detailed consideration of other aspects of neurogenesis.

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  1. Departments of Anatomy and Microbiology, University of Connecticut Health Center, Farmington, CT, USA

    Creighton H. Phelps & S. E. Pfeiffer

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  1. Creighton H. Phelps
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  1. Department of Anatomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Howard Holtzer

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Phelps, C.H., Pfeiffer, S.E. (1975). Neurogenesis and the Cell Cycle. In: Reinert, J., Holtzer, H. (eds) Cell Cycle and Cell Differentiation. Results and Problems in Cell Differentiation, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37390-2_4

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