Abstract
The first principle of neuronal differentiation is the generation of cellular diversity which, at least quantitatively, matches that found in the entire remainder of the embryo. More importantly, it is the characteristic differences among neurons (rather than properties which all neurons share to the exclusion of non-neural cells) that enables them to associate selectively and to assemble the synaptic circuits which are the substrates of macroscopic brain function. Neuronal differentiation must be viewed, therefore, not simply as a process by which “zygote” cells generate “nerve” cells, but rather as the systematic derivation from the zygote of a cell population with characteristically diverse properties and synaptic specificities. This review considers some aspects of neuronal specificity and the possible role(s) of the cell cycle and cell lineage in neuronal differentiation.
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Hunt, R.K. (1975). The Cell Cycle, Cell Lineage, and Neuronal Specificity. In: Reinert, J., Holtzer, H. (eds) Cell Cycle and Cell Differentiation. Results and Problems in Cell Differentiation, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37390-2_3
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DOI: https://doi.org/10.1007/978-3-540-37390-2_3
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