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Cell Changes in Neurospora

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Cell Cycle and Cell Differentiation

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 7))

Abstract

Replicating cells may be predictably altered by exogenous signals so that their progeny come to express a novel phenotype. Differentiation, a process so familiar and fundamental to biology, is exemplified by the vegetative life cycle of Neurospora crassa. There are three characteristic stages, and each consists of but a single basic cell type. Upon proper stimulation, the proliferation of recumbent vegetative hyphal cells is discontinued, and instead aerial hyphae are produced. Aerial hyphae grow and then eventually produce resting vegetative spores called macro-conidia. Figure 1 summarizes the relationships among the three cell types. These cell changes are at least superficially reminiscent of development in higher multicellular organisms; replicating stem cells are induced to produce a population of intermediary cells which pass through a critical number of cell cycles before they go on to form morphologically and functionally distinct, terminally differentiated cells in which mitotic activity has ceased. In an attempt to exploit what appears to be a particularly clear and simple model for eukaryotic cell differention, we have elected to examine aspects of the processes of aerialogenesis and macroconidiogenesis.

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Authors and Affiliations

  1. Department of Biology, University of California, Los Angeles, CA, USA

    R. E. Nelson, C. P. Selitrennikoff & R. W. Siegel

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  1. R. E. Nelson
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  2. C. P. Selitrennikoff
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  3. R. W. Siegel
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Editors and Affiliations

  1. Department of Anatomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Howard Holtzer

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© 1975 Springer-Verlag Berlin Heidelberg

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Nelson, R.E., Selitrennikoff, C.P., Siegel, R.W. (1975). Cell Changes in Neurospora. In: Reinert, J., Holtzer, H. (eds) Cell Cycle and Cell Differentiation. Results and Problems in Cell Differentiation, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-37390-2_13

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  • DOI: https://doi.org/10.1007/978-3-540-37390-2_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-21693-4

  • Online ISBN: 978-3-540-37390-2

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